Early Repolarization Pattern and Suicidal Risks: A Single Center Case-Control Study

Abstract

<jats:p>Background: Early repolarization pattern was reported to be associated with mental illness. However, its role in patients with the suicidal risks remains unclear. Objective: The aim of this study is to examine the frequency of Early repolarization pattern in patients with the suicidal risks compared with the age matched medical checkups. Method: A retrospective analysis of 27 patients with a history of suicide risks, including suicide attempt and nonsuicidal self-injury, and a family history of suicide. The presence of early repolarization pattern was compared in patients with suicidal risks and controls. Social and psychological factors were also compared among the patients with suicidal risks with or without Early repolarization pattern. Result: Comparing the controls, Early repolarization pattern was significantly observed in the patients (14 patients: 52%, 7 controls: 9%, P&lt;0.001). After logistic regression including the other clinical findings among the patients and controls, the presence of Early repolarization pattern was associated with the patients with the suicidal risks (95 % confidence interval, p &lt; 0.001). In the patients with suicide, there were no difference between the clinical factors compared with or without Early repolarization pattern. Conclusion: There could be association between Early repolarization pattern and the patients with the suicidal risks. Further studies are needed to confirm the association between suicidal risks and Early repolarization pattern.</jats:p>

Early Repolarization Pattern is Associated with Schizophrenia: A Single Center Experience in Japan

“…The copyright holder for this preprint this version posted July 17, 2020. ; https://doi.org/10.1101/2020.07.16.20155838 doi: medRxiv preprint 5 sudden cardiac death [11,12]. Recently, it has been reported that there are associations between ERP and attention-deficit hyperactivity disorder [13,14],and the patients with suicidal risks [15].…”

“…ERP and J-point elevation pattern, which are not uncommon and often observed in younger and healthier people [10], are arrestive electrocardiographic patterns associated with sudden cardiac death [11,12]. Recently, it has been reported that there are associations between ERP and attention-deficit hyperactivity disorder [13,14],and the patients with suicidal risks [15]. Moreover, Fitzgerald et.al reported that Patients with serious mental illness, especially schizophrenia/schizoaffective disorder, exhibit a significantly high rate of abnormal late potentials on Signal-averaged electrocardiogram (SAECG) and ERP [16].…”