Early Results of Magnetic Resonance–guided Focused Ultrasound Surgery of Adenomyosis: Analysis of 20 Cases

Fukunishi, Hiroaki; Funaki, Kaoru; Sawada, Katsuhiro; Yamaguchi, Kayo; Maeda, Takeyasu; Kaji, Yuichi

doi:10.1016/j.jmig.2008.06.010

Cited by 75 publications

(65 citation statements)

References 34 publications

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“…Class A adverse effects have included abdominal pain, mild sciatic/ buttock pain, genital bleeding/increased discharge, and a prolonged next period. 37 Zhang et al 33 reported a slightly increased frequency of abdominal pain (64% vs 71%) and skin reaction (0.8/2.4%) in patients with diffuse adenomyosis compared with those with focal disease.…”

Section: Safety/complicationsmentioning

confidence: 97%

“…Objective treatment success is demonstrated by a significant reduction in the uterine volume in several studies, with values from 12.7% to 54%. 36,37,41 The NPVR, where reported, ranges from 62.5% to 80.7% 33,35,36,39,41 (Table 1).…”

Section: Reduction Of Tissuementioning

confidence: 99%

“…Early studies examined the safety and efficacy of this technique. [36][37][38][39][40] More recently, the focus has moved to examine the level of reduction of symptoms in treated patients. 33,35,41 Treatment adjuncts have also been explored in an attempt to further enhance clinical effectiveness and improve efficiency.…”

Section: Studiesmentioning

confidence: 99%

“…41 Reported symptom reduction ranges from 25% to 83%. [36][37][38]41 Overall clinical effectiveness (defined as any degree of improvement in symptoms) ranges from 79% to 89%, with a significant proportion experiencing complete symptom relief (39%-46%). 33,35,[38][39][40]42 These effects appear to be sustained for at least 1-2 years 35,41 (Table 1).…”

Section: Reduction Of Symptomsmentioning

confidence: 99%

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MR-guided focused ultrasound for the treatment of adenomyosis: current insights

Chin¹,

Walbridge²,

Quinn³

2015

RRFU

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Adenomyosis is a benign gynecological condition causing significant morbidity among women of reproductive age. The available treatments are currently limited in number and efficacy. While hysterectomy is curative, it is unacceptable to many women, particularly those wishing to conserve their fertility. Magnetic resonance-guided focused ultrasound surgery is a noninvasive treatment method that has been used to effectively treat uterine leiomyomata, but until recently has not been routinely used to treat adenomyosis. This review summarizes the current understanding of adenomyosis and high-intensity focused ultrasound, and the recent research into the safety and efficacy of this technique.

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Section: Safety/complicationsmentioning

confidence: 97%

Section: Reduction Of Tissuementioning

confidence: 99%

Section: Studiesmentioning

confidence: 99%

Section: Reduction Of Symptomsmentioning

confidence: 99%

See 2 more Smart Citations

MR-guided focused ultrasound for the treatment of adenomyosis: current insights

Chin¹,

Walbridge²,

Quinn³

2015

RRFU

View full text Add to dashboard Cite

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“…Numerous therapeutic strategies such as hormone therapy, drug therapy, surgical intervention, uterine artery embolization and magnetic resonance-guided focused ultrasound (MRgFUS) ablation, are available to treat uterine fibroids and adenomyoma (2)(3)(4)(5)(6). The MRgFUS is proven to be a feasible, safe, efficacious treatment for uterine fibroids and adenomyoma (7)(8)(9)(10)(11)(12)(13)(14) by inducing coagulative necrosis, size reduction and functional loss of the lesion (7,15). The treatment outcome of MRgFUS ablation is normally assessed by contrast-enhanced T1-weighted image (cT1WI) with the use of gadolinium-based magnetic resonance contrast agent.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Diffusion-Weighted Imaging and Apparent Diffusion Coefficient Mapping Using Different B-Values for Magnetic Resonanceguided Focused Ultrasound Surgery: A Preliminary Study for Uterine Fibroid and Adenomyoma

Panicker

Abdullah

et al. 2017

JUMMEC

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The study was taken to assess the feasibility of diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) mapping using different b-values for magnetic resonance-guided focused ultrasound (MRgFUS) treatment of uterine fibroid and adenomyoma.The contrast-enhanced T1-weighted image (cT1WI) as well as DWIs and ADC maps of different b-values (i.e. 200, 600 and 800 s/mm²) were obtained from nine fibroid and five adenomyoma patients, immediately after, and 12 months after MRgFUS treatment. The image contrast score, non-perfused volume (NPV) and NPV ratio obtained were compared to determine the feasibility of DWI and ADC mapping for MRgFUS treatment outcome evaluation.Our finding showed that immediately after MRgFUS treatment, the DWI acquired using 200 s/mm² b-value gave the highest image contrast score among all other b-values. The NPV calculated from DWI of 200 s/ mm² showed the best correlation (R² = 0.938) with post-contrast NPV. At 12 months follow-up, there was no specific b-value considered as significantly superior to others in terms of image contrast. However, the NPVs and NPV ratios obtained from all DWIs and ADC maps of different b-values were in good agreement with the post-contrast NPV and NPV ratio.We observed that the DWI, particularly obtained with a low b-value (i.e. 200 s/mm²), is feasible for delineation and quantitative volumetric evaluation of the ablated region immediately after the MRgFUS treatment. At 12 months follow-up, both DWIs and ADC maps are feasible for NPV and NPV ratio calculation.

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Magnetic Resonance-Guided High-Intensity Focused Ultrasound: Gynecological Applications

Tan

Raman

2013

Image-Guided Cancer Therapy

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Early Results of Magnetic Resonance–guided Focused Ultrasound Surgery of Adenomyosis: Analysis of 20 Cases

Cited by 75 publications

References 34 publications

MR-guided focused ultrasound for the treatment of adenomyosis: current insights

MR-guided focused ultrasound for the treatment of adenomyosis: current insights

Evaluation of Diffusion-Weighted Imaging and Apparent Diffusion Coefficient Mapping Using Different B-Values for Magnetic Resonanceguided Focused Ultrasound Surgery: A Preliminary Study for Uterine Fibroid and Adenomyoma

Magnetic Resonance-Guided High-Intensity Focused Ultrasound: Gynecological Applications

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