Early results of real-time qualitative sonoelastography in the evaluation of parotid gland masses: A study with histopathological correlation

Çelebi, İrfan; Mahmutoğlu, Abdullah Soydan

doi:10.1258/ar.2012.120405

Cited by 38 publications

(35 citation statements)

References 20 publications

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“…The technique has been used to assess the hardness of various normal and abnormal tissues, [1][2][3][4][5][6] and to differentiate malignant from benign lesions in the breast, prostate, thyroid, lymph nodes and salivary glands. [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Ultrasound elastography uses either strain or shear wave velocity. 25,26 In strain elastography, tissue strain induced by compression with the probe is used as an indicator of hardness.…”

Section: Introductionmentioning

confidence: 99%

Effects of compression force on elasticity index and elasticity ratio in ultrasound elastography

Imaizumi¹,

Sasaki²,

Sakamoto³

et al. 2014

Dentomaxillofacial Radiology

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Objectives: The purpose of this study was to investigate the relationship between compression force and hardness values in ultrasound elastography. Methods: Ultrasound elastography was performed using an elastography phantom, comprising inclusions with different elasticities and echogenicities. The compression force was set to approximately 100 gw (light force) and approximately 500 gw (heavy force). The elasticity index (EI) of the inclusion was measured. The EI was a relative hardness value of a structure within an elastographic image. Similarly, the EI of the background was measured as a reference. The elasticity ratio (ER) was calculated as the EI of the inclusion divided by the EI of the reference. Results: The hardness of the phantom could be discerned with both the EI and ER, regardless of the compression force. The EI and ER with heavy force tended to be higher than those with light force, but the difference was not significant. A strong correlation was observed between the EI and ER of soft structures, whereas the correlation between the EI and ER of hard structures was weak, and the ER values varied widely.

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Section: Introductionmentioning

confidence: 99%

Effects of compression force on elasticity index and elasticity ratio in ultrasound elastography

Imaizumi¹,

Sasaki²,

Sakamoto³

et al. 2014

Dentomaxillofacial Radiology

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“…[4][5][6][7][8][9] These reports indicated an especially variable appearance of pleo- morphic adenomas on elastography. [6][7][8]10 Although benign tumors other than pleomorphic adenomas appeared softer in qualitative elastographic studies, some appeared softer and others harder.…”

Section: Discussionmentioning

confidence: 88%

“…[6][7][8]10 Although benign tumors other than pleomorphic adenomas appeared softer in qualitative elastographic studies, some appeared softer and others harder. 4,8,9 In a study by Bhatia et al, 6 pleomorphic adenomas appeared stiffer than other benign parotid gland tumors, with a wide distribution of maximum elasticity values (range, 16.4-214.8 kPa). 6 These data show that SWE cannot differentiate benign parotid gland tumors from malignant counterparts by measurement of the maximum shear elastic modulus.…”

Section: Discussionmentioning

confidence: 95%

“…1-3 However, elasticity imaging (both by qualitative and quantitative elastographic methods) is not definitive in distinguishing benign from malignant lesions in the salivary glands. [4][5][6][7][8][9] In particular, the appearance of pleomorphic adenomas Deniz Cebi Olgun, MD, Fatih Kantarci, MD, Umit Taskin, MD, Fahrettin Kilic, MD, Mehmet Faruk Oktay, Serdar Altinay, MD, Nuray Kepil, MD, Ibrahim Adaletli, MD, Mehmet Ada, MD, Ismail Mihmanli, MD Received July 2, 2013, Objectives-The purpose of this study was to evaluate whether the relative proportions of stromal to cellular components of pleomorphic adenomas have an effect on the shear elastic modulus determined by shear wave elastography (SWE).Methods-This study was approved by the Ethics Committee of our institution and performed between September 2011 and December 2012. Thirty-five patients who underwent surgery for a parotid mass were included in the study.…”

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confidence: 99%

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Relative Proportions of Stromal to Cellular Components of Pleomorphic Adenomas

Olgun

Kantarcı

Taşkın

et al. 2014

J of Ultrasound Medicine

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Determination With Shear Wave Elastography easurement of tissue stiffness by sonography is a relatively new and expanding field of research. The principle theory in elastography is that malignant tumors are stiffer than benign ones. Preliminary evidence suggests that elastographic techniques may have a discriminatory value for detecting malignancies in the breast and thyroid gland. 1-3 However, elasticity imaging (both by qualitative and quantitative elastographic methods) is not definitive in distinguishing benign from malignant lesions in the salivary glands. [4][5][6][7][8][9] In particular, the appearance of pleomorphic adenomas Deniz Cebi Olgun, MD, Fatih Kantarci, MD, Umit Taskin, MD, Fahrettin Kilic, MD, Mehmet Faruk Oktay, Serdar Altinay, MD, Nuray Kepil, MD, Ibrahim Adaletli, MD, Mehmet Ada, MD, Ismail Mihmanli, MD Received July 2, 2013, Objectives-The purpose of this study was to evaluate whether the relative proportions of stromal to cellular components of pleomorphic adenomas have an effect on the shear elastic modulus determined by shear wave elastography (SWE).Methods-This study was approved by the Ethics Committee of our institution and performed between September 2011 and December 2012. Thirty-five patients who underwent surgery for a parotid mass were included in the study. The maximum shear elastic modulus of the mass was measured by SWE. Pleomorphic adenomas were histopathologically subdivided into stroma-poor, intermediate-stroma, and stroma-rich tumors based on the relative proportion of stromal to cellular components.Results-The maximum shear elastic modulus values of the pleomorphic adenomas ranged from 12.6 to 291.9 kPa (mean ± SD, 120.9 ± 92.8 kPa). The Friedman test revealed a statistically significant relationship between the stromal amount and maximum shear elastic modulus (P < .001). Stroma-poor adenomas (mean, 32.3 ± 27.7 kPa; range, 12.6-81.1 kPa) were softer on SWE than stroma-rich adenomas (mean, 174.1 ± 48.4 kPa; range, 92.7-217.2 kPa; P = .009). No such significant difference was detected between stroma-poor and intermediate-stroma tumors (mean, 146.3 ± 106.1 kPa; range, 19.1-291.9 kPa; P = .062) or between intermediate-stroma and stroma-rich tumors (P = .465).Conclusions-Shear wave elastography depicts pleomorphic adenomas with a variable appearance, which is due to the relative proportions of stromal to cellular contents in the tumors.

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“…Because many diseases correlate with changes in the mechanical properties of tissues, this technique has been successfully applied in detecting and assessing various pathologies of thyroid gland, breast, lymph nodes, major salivary gland, prostate, kidney, and liver [1][2][3][11][12][13][14][15][16][17]. However, to our knowledge, no study has been reported previously in the medical literature using real time sonoelastography to assess gallbladder polyps.…”

Section: Discussionmentioning

confidence: 99%

The use of real-time elastography in the assessment of gallbladder polyps: preliminary observations

Teber¹,

Tan²,

Dönmez³

et al. 2014

Med Ultrason

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Aims: Gallbladder polyps often have a benign nature. Current guidelines suggest surgical removal of polyps greater than 10 mm. However, the accuracy of the size criteria is limited because neoplasia can be found in gallbladder polyps less than 10 mm. The aim of this study was to evaluate the feasibility of real time elastography for gallbladder polyps and to demonstrate the elasticity properties of the polyps. Material and method: Fifty-three polypoid lesions of the gallbladder were prospectively examined with real-time elastography. Of these patients, 52 had a diagnosis of benign gallbladder polyps and one patient was accepted as a gallbladder carcinoma due to its clinical and radiological findings. B-mode and real-time elastographic images were simultaneously presented as a two-panel image, and the elastogram was displayed in a color scale that ranged from red (greatest strain, softest component), to green (average strain, intermediate component), to blue (no strain, hardest component). Results: The mean size for benign gallbladder polyps was 7.2 ± 3 mm (range, 5-21 mm). All benign gallbladder polyps on consecutive real-time elastographic images appeared as having a high-strain elastographic pattern. Only one patient who was accepted with gallbladder carcinoma had a gallbladder polyp with low elasticity properties. Conclusions: Our study showed that real time elastography of gallbladder polyps is feasible. This novel approach may be useful for the characterization of polypoid lesions of the gallbladder.

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Early results of real-time qualitative sonoelastography in the evaluation of parotid gland masses: A study with histopathological correlation

Abstract: Although sonoelastography seems to be promising in the differentiating of low-grade malignancies, the primary role of radiology is currently limited to determination of localization, size, and morphology of parotid tumors.

Cited by 38 publications

References 20 publications

Effects of compression force on elasticity index and elasticity ratio in ultrasound elastography

Effects of compression force on elasticity index and elasticity ratio in ultrasound elastography

Relative Proportions of Stromal to Cellular Components of Pleomorphic Adenomas

The use of real-time elastography in the assessment of gallbladder polyps: preliminary observations

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