Early Splenectomy and Survival of Inbred Mice

Kalpaktsoglou, Pitsa K.; Yunis, E. J.; Good, Robert A.

doi:10.1038/215633a0

Cited by 16 publications

(8 citation statements)

References 23 publications

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“…In the present series of observations, made at different times of the year in the same colony, we observed, as in our initial study [6], that neonatal splenectomy leads to a higher mortality than is observed on un operated mice. Sham-operated mice show a mortality that falls between those two groups.…”

Section: Discussionsupporting

confidence: 81%

“…Sham-operated mice show a mortality that falls between those two groups. In these experiments, due probably to better husban dry, the mortality of NB splenectomized mice was considerably lower than that recorded in our previous study [6]. K ubai and A uerbach [10] have questioned the effect of early splenectomy on the mortality of inbred mice and, indeed, have correctly attributed the high mortality associated with splenectomy, in our original study, to the conditions of husbandry in our colony.…”

Section: Discussionmentioning

confidence: 46%

“…We believe that the significant fact emerging from our present study, as from the ear lier ones [4][5][6], is that a higher mortality rate can be expected in neona tally splenectomized mice than in normal or sham-operated mice in most environments; this is due to a combination of deficiency of resistance plus exposure to potential pollution. This increased mortality is frequent be tween the third and fourth weeks, but not noticeable in the first week of life in immunologic development.…”

Section: Discussionmentioning

confidence: 83%

“…They observed no increase in mortality attributable to sple nectomy in a colony of mice maintained under ideal conditions. We con tend that it was most fortunate that the risk of infection was great in the environment in which our original study [6] was carried out. Our data in dicate that such an environment places a greater burden on the younger splenectomized mice than on mice splenectomized later in life.…”

Section: Discussionmentioning

confidence: 97%

“…In our original papers [4][5][6], we emphasized that splenectomy per formed early in life decreases the chances of survival of inbred mice and that there is a difference in mortality and wasting syndrome between mice splenectomized at birth and those splenectomized at a later date, namely at the age of 2 or 4 weeks.…”

Section: Introductionmentioning

confidence: 99%

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Mortality and Five Classes of Mouse Immunoglobulins in Early Splenectomy

Kalpaktsoglou¹,

Good²

1973

Int Arch Allergy Immunol

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We studied the effect of early splenectomy on the mortality and on the serum levels of the five classes of immunoglobulins during the first months of life in C3H mice. The mortality observed in newborn splenectomized mice was statistically higher than that observed in normal sham-splenectomized mice. Splenectomy at birth inhibited the normal development of the serum levels of IgM and affected the levels of IgG_1; IgG_2a, IgG_2b and IgA either slightly or not at all.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 46%

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Mortality and Five Classes of Mouse Immunoglobulins in Early Splenectomy

Kalpaktsoglou¹,

Good²

1973

Int Arch Allergy Immunol

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The role of Spleen in development of lympho‐hemopoietic tissues: Effect of splenectomy on development of blood cells, bone marrow, thymus and lymph node

1968

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The effects of splenectomy at birth and two and four weeks of age on the development of lymphoid and hematopoietic tissues has been compared in C3H/Bi mice. During the neonatal period normal mice showed changes in total leukocyte count, and in absolute members of the specific cell types. The predominant changes included an initial fall of numbers of granulocytes and steady increase in numbers of lymphocytes during the first six weeks of life. Neonatal splenectomy interfered with the normal developmental pattern by interfering with normal growth of numbers of circulating lymphocytes while splenectomy at two and four weeks of age produced increases in numbers of both circulating lymphocytes and granulocytes. Neonatal splenectomy produced effects on development of bone marrow, peripheral lymph nodes and thymus. The major influence seemed to involve decrease in percentages o f small, densely stained lymphocytes in thymus and peripheral lymph nodes.

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Factors Influencing the Generation of Phenotypic Heterogeneity in Mammary Tumors

Kim

1985

Biological Responses in Cancer

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Early Splenectomy and Survival of Inbred Mice

Cited by 16 publications

References 23 publications

Mortality and Five Classes of Mouse Immunoglobulins in Early Splenectomy

Mortality and Five Classes of Mouse Immunoglobulins in Early Splenectomy

The role of Spleen in development of lympho‐hemopoietic tissues: Effect of splenectomy on development of blood cells, bone marrow, thymus and lymph node

Factors Influencing the Generation of Phenotypic Heterogeneity in Mammary Tumors

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