Early-stage cervical cancer treatment – what’s new?

Abstract

The gold standard of treatment for patients with early-stage cervical cancer is radical hysterectomy, in agreement with the entire scientific community. During the last decade, growing evidence has supported the minimally invasive approach. Several studies have suggested that the minimally invasive approach could improve surgical and perioperative outcomes. Because of these findings, ESCO/ESTRO/ESP guidelines state that a “minimally invasive approach is favoured” in comparison with open surgery, as a grade B recommendation. Because of the lack of a grade A recommendation, this randomized Laparoscopic Approach to Cervical Cancer trial evaluated open vs. minimally invasive approach in the early stage. It demonstrated an increase in mortality among patients treated with minimally invasive surgery, revolutionizing current thinking on the primary surgical approach to early cervical cancer. The aim of this study is to analyse which is the best treatment for early cervical cancer and which approach is the most effective at the moment. Further studies are needed to state with certainty the appropriateness of the treatments offered to patients with early cervical cancer.

Intervenções Inovadoras Na Promoção Da Saúde: Vacinas Terapêuticas E Estratégias De Prevenção Do HPV

“…No entanto, essa abordagem traz consequências indesejáveis, como náuseas, diarreia, vômitos, queda de cabelo e fadiga (REGALADO PORRAS; CHÁVEZ NOGUEDA; POITEVIN CHACÓN, 2018). Por outro lado, a cirurgia envolve vários procedimentos como criocirurgia, ablação a laser e conização para lesões prémalignas, e histerectomia e linfadenectomia que visam eliminar o tumor em estágios mais avançados (DIO et al, 2023;GUIMARÃES et al, 2022). Infelizmente, esta técnica acarreta riscos cirúrgicos, incluindo infecção, recorrência, disfunção sexual e sangramento (DIO et al, 2023).…”

“…Por outro lado, a cirurgia envolve vários procedimentos como criocirurgia, ablação a laser e conização para lesões prémalignas, e histerectomia e linfadenectomia que visam eliminar o tumor em estágios mais avançados (DIO et al, 2023;GUIMARÃES et al, 2022). Infelizmente, esta técnica acarreta riscos cirúrgicos, incluindo infecção, recorrência, disfunção sexual e sangramento (DIO et al, 2023). Por último, a radioterapia depende de radiação ionizante que pode causar cansaço e irritação da pele (CHARGARI et al, 2022).…”

Efficacy and safety of consolidation chemotherapy after adjuvant therapy in stage IB-IIA cervical cancer patients with risk factors: a retrospective single-center study

“…Although radical surgery is currently the standard treatment for most early-stage CC patients, postoperative occurrence may occur partly due to insufficient radicality or potential tumor dissemination during colpotomy (13). In addition, patients with high or intermediate risk factors are found to have higher recurrence rate than others in the early-stage subpopulation (14,15).…”

Effectiveness of acupuncture on urinary retention after radical hysterectomy for cervical cancer in China: a systematic review and meta-analysis

“…Analysis of the acupuncture point-taking characteristics of the included study revealed that the selected points were mainly based on the bladder channel of foot-taiyang, the spleen channel of foot-shaoyin, the yin channel and the liver channel of Postoperative UR in cervical cancer is generally defined as those who cannot urinate on their own or can urinate on their own but the residual urine volume is greater than 100 mL for 14 days or more after surgery (32). Currently, RH is considered to be the mainstay of treatment for early-stage cervical cancer (33). The scope of surgical resection includes the uterus, fallopian tubes, upper vagina, main ligament and complete clearance of paravaginal and pelvic lymph nodes, and during the resection process, the pelvic autonomic nerves will be destroyed, and some of the nerves that innervate the bladder will be severed, which, together with the perioperative psychosomatic condition, the change of the anatomical position of the pelvic organs, surgical anesthesia and postoperative pain, lead to bladder contraction and sensory dysfunction, as well as voiding disorders and UR (34)(35)(36)(37)(38)(39).…”