Early stage clear cell adenocarcinoma coexisting with tubular adenoma and adenoma with clear cell change in the colon

Tochio, Tomomasa; Baba, Youichirou; Asakawa, Hiroki; Nose, Kenji; Tsuruga, Satomi; Kumazawa, Hiroaki; Isono, Yoshiaki; Tanaka, Hiroki; Matsusaki, Shimpei; Sase, Tomohiro; Saito, Tomonori; Okano, Hiroshi; Mukai, Katsumi; Kushima, Ryoji

doi:10.1007/s12328-020-01334-x

Clin J Gastroenterol

2021

DOI: 10.1007/s12328-020-01334-x

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Early stage clear cell adenocarcinoma coexisting with tubular adenoma and adenoma with clear cell change in the colon

Tomomasa Tochio¹,

Youichirou Baba²,

Hiroki Asakawa³

et al.

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2023

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Colonic de novo Clear Cell Adenocarcinoma of Intestinal-Type: A Case Report and Review of the Literature

Li,

Chen,

Chen

et al. 2023

Int J Surg Pathol

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Colorectal clear cell adenocarcinomas are rare tumors. They can be divided into two types: intestinal- and Müllerian-type. Most intestinal-type clear cell adenocarcinomas show a composite morphology, and most early-stage (T1) intestinal-type clear cell adenocarcinomas have an adenoma component. We report an additional early-stage (T1) colonic clear cell adenocarcinoma that was a de novo adenocarcinoma without any adenoma component. It had a pure morphology and the smallest size (0.6 cm) ever reported. Immunohistochemical results demonstrated an intestinal phenotype (KRT20+, KRT7−, CEA+, and CDX2+). Periodic acid-schiff and alcian blue stains were both negative, which demonstrated decrease in mucin expression in the clear tumor cells. Enteroblastic differentiation was observed in a few colorectal clear cell adenocarcinomas in the literature, while it had not been observed in the present tumor. The tumor did not have deep submucosal invasion and cancer embolus, endoscopic submucosal dissection with regular follow-up was an appropriate treatment for the patient. Due to the rarity and diversity of primary colorectal clear cell adenocarcinomas, the cause of clear cytoplasm change and the impact on patient prognosis remain unknown. Accumulating evidence indicates that clear cell adenocarcinomas of intestinal-type is a histological variant of colorectal adenocarcinoma.

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Colonic de novo Clear Cell Adenocarcinoma of Intestinal-Type: A Case Report and Review of the Literature

Li,

Chen,

Chen

et al. 2023

Int J Surg Pathol

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Early stage clear cell adenocarcinoma coexisting with tubular adenoma and adenoma with clear cell change in the colon

Cited by 1 publication

References 24 publications

Colonic de novo Clear Cell Adenocarcinoma of Intestinal-Type: A Case Report and Review of the Literature

Colonic de novo Clear Cell Adenocarcinoma of Intestinal-Type: A Case Report and Review of the Literature

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