Early‐stage idiopathic mesenteric phlebosclerosis incidentally combined with adenocarcinoma of the ascending colon: A report of two cases

Ichimata, Shojiro; Aoyagi, Daiju; Kobayashi, Mikiko; Sugihara, Takehiko; Nishio, Akira; Maruyama, Masafumi; Shiozawa, Satoshi

doi:10.1111/pin.12614

Cited by 7 publications

(3 citation statements)

References 3 publications

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“…In advanced mesenteric phlebosclerosis cases, edema, ulceration, rigidity, and stenosis are also observed by endoscopy [10, 40–46]. Several mesenteric phlebosclerosis cases have also reportedly led to chronic ischemic colitis [40], and multiple cases of colon cancer have coincided with mesenteric phlebosclerosis [47–50]. However, the etiological relationship between colon cancer and mesenteric phlebosclerosis remains unknown, and it is still considered an incidental concurrence.…”

Section: Resultsmentioning

confidence: 99%

Adverse Events Associated with Ethical Kampo Formulations: Analysis of the Domestic Adverse-Event Data Reports of the Ministry of Health, Labor, and Welfare in Japan

Shimada

Fujimoto

Nogami

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Objectives. Traditional Japanese Kampo medicines have been integrated into the Japanese national health-care system. In Japan, the Ministry of Health, Labor, and Welfare’s website discloses adverse drug-event data that have been obtained from medical personnel reports investigated by the Pharmaceutical and Medical Devices Agency. Using these data, we investigated adverse events associated with ethical Kampo formulations. Methods. Reports of adverse events associated with ethical Kampo formulations from the domestic adverse-event data were obtained from July 30, 2003, to March 31, 2018. Adverse events were then categorized, and the relationships between categories of adverse events and crude drugs were analyzed. Results. There were 4,232 reported adverse events associated with ethical Kampo formulations. The numbers of events by category were as follows: events related to liver injury, 1,193; lung injury, 1,177; pseudoaldosteronism, 889; mesenteric phlebosclerosis, 223; drug eruption, 185; and others, 565. Among events related to both liver injury and lung injury, approximately 70% were suspected to be induced by Kampo formulations containing Scutellariae Radix. The pseudoaldosteronism-related events, which are induced by Glycyrrhizae Radix, included several events related to muscle injury, heart failure, and arrhythmia. Events related to mesenteric phlebosclerosis, believed to be induced by long-term use of Kampo formulas containing Gardeniae Fructus, increased remarkably during the study period. Among the events related to drug eruption, approximately 35% were suspected to be induced by Kampo formulations containing Ephedrae Herba. Conclusion. Kampo medicines may cause various adverse events. The present results provide valuable information regarding adverse events associated with Kampo medicines from the viewpoint of patient safety.

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Section: Resultsmentioning

confidence: 99%

Adverse Events Associated with Ethical Kampo Formulations: Analysis of the Domestic Adverse-Event Data Reports of the Ministry of Health, Labor, and Welfare in Japan

Shimada

Fujimoto

Nogami

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…To date, only a handful of IMP cases with concomitant adenocarcinoma has been reported in the literature. 15 , 30 …”

Section: Discussionmentioning

confidence: 99%

Idiopathic Mesenteric Phlebosclerosis: A Single-Institute Experience in Taiwan

Chou

Chang²,

et al. 2023

Turk J Gastroenterol

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Background: Idiopathic mesenteric phlebosclerosis is a rare condition with unclear pathogenesis. This study aimed to investigate the clinical features, diagnostic modalities, treatments, and outcomes of idiopathic mesenteric phlebosclerosis patients in Taiwan. Methods: Idiopathic mesenteric phlebosclerosis patients diagnosed by the typical characteristic of tree-like mesenteric venous calcifications on plain abdominal radiography or computed tomography between January 1992 and July 2021 were retrospectively analyzed. Results : Totally, 36 idiopathic mesenteric phlebosclerosis patients were enrolled (50% females; mean age, 61.6 years). Among the included patients, 26 (72.2%) and 10 (27.7%) were symptomatic and asymptomatic, respectively. Abdominal pain (61.1%) accounted for the majority of all symptoms, followed by fever, diarrhea, and bloody stools. Our results showed that 83.3% of patients had at least 1 risk factor, whereas 16.6% of patients had none. Moreover, among the included patients, 36.1%, 44.4%, 50.0%, 38.8%, and 8.3% had cardiovascular disease, chronic renal disease, cancer, chronic liver disease, and diabetes mellitus, respectively. Our findings showed 94.4% of patients were diagnosed via abdominal computed tomography and plain abdominal radiography, whereas 5.6% of patients were diagnosed via plain abdominal radiography. The ascending colon was the most commonly involved site (100%). Our findings showed that 91.6% of patients experienced good recovery after conservative treatment, except for the 3 who died of sepsis and respiratory failure. By contrast, 8.3% of idiopathic mesenteric phlebosclerosis patients underwent colectomy. The average follow-up duration was 62.5 months. Conclusions: Idiopathic mesenteric phlebosclerosis remains a rare disease in Taiwan. Plain abdominal radiography and computed tomography can be utilized for establishing a definite diagnosis. Conservative treatment is usually adequate for most patients, with surgical treatment only indicated for severe cases.

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“…Collagen fiber staining can be used to highlight denatured blood vessels and sediments, elastic fiber staining can help identify the type of vessels affected, and Congo red staining is critical for the differential diagnosis form amyloidosis. [ 5 ]…”

Section: Discussionmentioning

confidence: 99%

Idiopathic mesenteric phlebosclerosis associated with use of Chinese herbal medicine

Wen¹,

Zhao²,

Huang

et al. 2020

Medicine

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Rationale: Idiopathic mesenteric phlebosclerosis (IMP) is a rare form of ischemic colitis. It is more common in the Asian population people with Asian ancestry. Disease pathogenesis and etiology are not fully elucidated but may be associated with the long-term intake of toxins and other substances, including Chinese herbs. The disease has typical radiological and endoscopic features. Radiologic examination combined with endoscopy can lead to a conclusive diagnosis. Patient concerns: We present 2 cases of IMP: in male patients aged 66 and 79 years. The first patient presented with diarrhea and abdominal pain, and the second patient presented with numbness of limbs and abdominal discomfort. These patients had a history of long-term use of Chinese herbal medicine (CHM). Diagnosis: Both patients were diagnosed with IMP by endoscopy and radiology, and the diagnosis confirmed by biopsy in the first patient. Interventions: The first patient was advised to stop using CHM. Both patients were given conservative treatment and were followed up regularly. Outcomes: Symptoms improved after conservative treatment. The patients had no obvious discomfort during the follow-up period. Conclusion: We suspect that the disease is induced by the long-term use of CHM, and dosage and duration of use may determine disease severity.

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Early‐stage idiopathic mesenteric phlebosclerosis incidentally combined with adenocarcinoma of the ascending colon: A report of two cases

Cited by 7 publications

References 3 publications

Adverse Events Associated with Ethical Kampo Formulations: Analysis of the Domestic Adverse-Event Data Reports of the Ministry of Health, Labor, and Welfare in Japan

Adverse Events Associated with Ethical Kampo Formulations: Analysis of the Domestic Adverse-Event Data Reports of the Ministry of Health, Labor, and Welfare in Japan

Idiopathic Mesenteric Phlebosclerosis: A Single-Institute Experience in Taiwan

Idiopathic mesenteric phlebosclerosis associated with use of Chinese herbal medicine

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