Early-stage symptomatic osteoarthritis of the knee — time for action

Mahmoudian, Armaghan; Lohmander, L. Stefan; Mobasheri, Ali; Englund, Martin; Luyten, Frank P.

doi:10.1038/s41584-021-00673-4

Cited by 220 publications

(191 citation statements)

References 131 publications

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“…In the regions of cartilage damage, subchondral plate and subarticular spongiosa thickness progressive increase ( Madry et al, 2016 ), which diminish its biomechanical properties. In addition, Hoffa fat pad will suffer from inflammation, quadriceps femoris become weakness, and knee joint ligament will be laxity ( Mahmoudian et al, 2021 ).…”

Section: Mechanisms and Symptoms Of Koamentioning

confidence: 99%

Benefits and Mechanisms of Exercise Training for Knee Osteoarthritis

et al. 2021

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Knee osteoarthritis is a chronic degenerative disease. Cartilage and subchondral bone degeneration, as well as synovitis, are the main pathological changes associated with knee osteoarthritis. Mechanical overload, inflammation, metabolic factors, hormonal changes, and aging play a vital role in aggravating the progression of knee osteoarthritis. The main treatments for knee osteoarthritis include pharmacotherapy, physiotherapy, and surgery. However, pharmacotherapy has many side effects, and surgery is only suitable for patients with end-stage knee osteoarthritis. Exercise training, as a complementary and adjunctive physiotherapy, can prevent cartilage degeneration, inhibit inflammation, and prevent loss of the subchondral bone and metaphyseal bone trabeculae. Increasing evidence indicates that exercise training can improve pain, stiffness, joint dysfunction, and muscle weakness in patients with knee osteoarthritis. There are several exercise trainings options for the treatment of knee osteoarthritis, including aerobic exercise, strength training, neuromuscular exercise, balance training, proprioception training, aquatic exercise, and traditional exercise. For Knee osteoarthritis (KOA) experimental animals, those exercise trainings can reduce inflammation, delay cartilage and bone degeneration, change tendon, and muscle structure. In this review, we summarize the main symptoms of knee osteoarthritis, the mechanisms of exercise training, and the therapeutic effects of different exercise training methods on patients with knee osteoarthritis. We hope this review will allow patients in different situations to receive appropriate exercise therapy for knee osteoarthritis, and provide a reference for further research and clinical application of exercise training for knee osteoarthritis.

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Section: Mechanisms and Symptoms Of Koamentioning

confidence: 99%

Benefits and Mechanisms of Exercise Training for Knee Osteoarthritis

et al. 2021

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“…Cartilage lesions can eventually progress to OA, which has a enormous impact on the social economy and health ( Mahmoudian et al, 2021 ). Early chondroplasty for cartilage lesions avoids the need for chondrocyte implantation or arthroplasty if the disease progresses further, which potentially decrease the socio-economic burden.…”

Section: Manuscript Formattingmentioning

confidence: 99%

“…The cartilage defects play a vital role in cartilage degeneration. Without effective treatment, such degeneration will eventually lead to osteoarthritis (OA) that can affect the patients’ work and daily life seriously and represent a significant health and economic burden on society ( Mahmoudian et al, 2021 ). In a recent epidemiological study, OA occurred in 54.4 million (22.7%) adults, and 43.5% of the patients reported negative impact on their life due to limitation of motion ( Barbour et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

The Arthroscopic Application of Radiofrequency in Treatment of Articular Cartilage Lesions

Lin

Deng

Xiong

et al. 2022

Front. Bioeng. Biotechnol.

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Articular cartilage lesion is a common disease to be treated by arthroscopic surgery. It will eventually progress to osteoarthritis without proper management, which can affect patients’ work and daily life seriously. Although mechanical debridement and laser have been used clinically for its treatment, due to their respective drawbacks, radiofrequency has drawn increasing attention from clinicians as a new technique with more advantages. However, the safety and efficacy of radiofrequency have also been questioned. In this article, the scope of application of radiofrequency was reviewed following an introduction of its development history and mechanism, and the methods to ensure the safety and effectiveness of radiofrequency through power and temperature control were summarized.

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“…Osteoarthritis is a common chronic disease characterized by articular cartilage degeneration and persistent inflammation of the joint capsule, which seriously endangers the health of middle-aged and elderly people worldwide. − The goal of osteoarthritis treatment focuses on the control over pain and improvement of joint function via physical, drug, or surgical treatment . Among them, drug treatment, such as anti-inflammatory drugs and painkillers, is an efficient way for early osteoarthritis treatment because of its higher acceptance rate, lower treatment cost, better therapeutic effect, and more safety. − However, the frequent use of drugs via oral or intravenous injection to relieve inflammation and pain may cause new questions, such as misses, overdoses, drug resistance, and even severe gastrointestinal reactions, especially in elderly people due to the age-related physical decline.…”

Section: Introductionmentioning

confidence: 99%

Ice-Inspired Lubricated Drug Delivery Particles from Microfluidic Electrospray for Osteoarthritis Treatment

et al. 2021

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Particle-based drug delivery systems have a demonstrated value in osteoarthritis treatment. Research in this area trends to developing functional particles to improve the therapeutic effects. Herein, inspired by the super lubricated surface of ice that consists of a contiguous and ultrathin layer of bound water, we developed a 2-methylacryloyloxyethyl phosphorylcholine (MPC) decorated methacrylate anhydridehyaluronic acid (HAMA) drug delivery particle with satisfying strength and enhanced lubrication from microfluidic electrospray for osteoarthritis treatment. Benefiting from the precise control of microfluidic electrospray flows, the generated drug delivery particles are imparted with well-tailored sizes and good dispersion. As the generated HAMA particles were modified by MPC with the positively (N + (CH 3 ) 3 ) and negatively (PO 4 − ) charged chemical groups, they were imparted with enhanced lubrication effect and reduced friction on the joint interface by forming a hydrated lubricating layer. We have demonstrated that the MPC-modified HAMA particles could be employed as microcarriers for loading diclofenac sodium (DS) to inhibit the inflammatory response, thus further enhancing the osteoarthritis therapeutic effect in vivo and in vitro. Thus, the proposed drug delivery particles with satisfactory biocompatibility and therapeutic effect are great potential for clinical applications.

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Early-stage symptomatic osteoarthritis of the knee — time for action

Cited by 220 publications

References 131 publications

Benefits and Mechanisms of Exercise Training for Knee Osteoarthritis

Benefits and Mechanisms of Exercise Training for Knee Osteoarthritis

The Arthroscopic Application of Radiofrequency in Treatment of Articular Cartilage Lesions

Ice-Inspired Lubricated Drug Delivery Particles from Microfluidic Electrospray for Osteoarthritis Treatment

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