Early stages of calcium-phosphate layer formation in bioglasses

Kim, Cheol Y.; Clark, A. E.; Hench, Larry L.

doi:10.1016/0022-3093(89)90011-2

Cited by 263 publications

(163 citation statements)

References 10 publications

Supporting

Mentioning

155

Contrasting

Unclassified

Order By: Relevance

“…A number of publications investigate the ability of fluoride-containing bioactive glasses to form apatite in SBF [18,[24][25][26]. Fujii et al [24] tested fluoride-containing bioactive glasses in SBF and performed XRD on the SBF-treated samples.…”

Section: Fluoride-containing Bioactive Glasses In the Literaturementioning

confidence: 99%

Fluoride-containing bioactive glasses: Effect of glass design and structure on degradation, pH and apatite formation in simulated body fluid

Brauer

Karpukhina

O’Donnell³

et al. 2010

Acta Biomaterialia

292

233

View full text Add to dashboard Cite

Effect of fluoride content of bioactive glasses on apatite deposition in simulated body fluid 2/15Summary Bioactive glasses are able to bond to bone through formation of carbonated hydroxyapatite in body fluids, and fluoridereleasing bioactive glasses are of interest for both orthopaedic and in particular dental applications for caries inhibition.Melt-derived glasses in the system SiO 2 -P 2 O 5 -CaO-Na 2 O with increasing amounts of CaF 2 were prepared by keeping network connectivity and the ratio of all other components constant.pH change, ion release and apatite formation during immersion of glass powder in simulated body fluid at 37°C over up to two weeks were investigated. Crystal phases formed in SBF were characterised using infra-red spectroscopy, X-ray diffraction with Rietveld analysis and solid-state nuclear magnetic resonance spectroscopy ( 19 F and 31 P MAS-NMR).Results show that incorporation of fluoride resulted in a reduced pH rise in aqueous solutions compared to fluoride-free glasses and in formation of fluorapatite (FAp), which is more chemically stable than hydroxyapatite or carbonated hydroxyapatite and therefore is of interest for dental applications. However, for increasing fluoride content in the glass, fluorite (CaF 2 ) was formed at the expense of FAp. Apatite formation could be favoured by increasing the phosphate content in the glass, as the release of additional phosphate into the SBF would affect supersaturation in the solution and

show abstract

Section: Fluoride-containing Bioactive Glasses In the Literaturementioning

confidence: 99%

Fluoride-containing bioactive glasses: Effect of glass design and structure on degradation, pH and apatite formation in simulated body fluid

Brauer

Karpukhina

O’Donnell³

et al. 2010

Acta Biomaterialia

292

233

View full text Add to dashboard Cite

show abstract

“…Spectra after tris buffer immersion for 1 week (Figures 3a, b) showed either a single band or a split band at approximately 560 cm -1 . This is the most characteristic region for apatite and other phosphates, and it corresponds to P-O bonding vibrations in a PO 4 3-tetrahedron and indicates presence of crystalline calcium phosphates including hydroxyapatite (HAp) and HCA [16]. A single band in this region suggests presence of non-apatitic or amorphous calcium phosphate (ACP) which is usually taken as indication of presence of precursors to apatite [17].…”

Section: Apatite Deposition In Tris Buffermentioning

confidence: 99%

High phosphate content significantly increases apatite formation of fluoride-containing bioactive glasses

et al. 2011

View full text Add to dashboard Cite

Bioactive glass-containing toothpastes for treating dentine hypersensitivity work by precipitating hydroxy-carbonate apatite (HCA) onto the tooth surface, but concerns exist over the long-term durability of HCA in the mouth. Fluoridecontaining bioactive glasses form fluorapatite (FAp) in physiological solutions, which is more chemically stable against acid attack.The influence of phosphate content on apatite formation was investigated by producing a low-phosphate (about 1 mol% P 2 O 5 ) and a high-phosphate (about 6 mol%) series of melt-derived bioactive glasses in the system SiO 2 -P 2 O 5 -CaONa 2 O; increasing amounts of CaF 2 were added by keeping the ratio of all other components constant. pH change, ion release and apatite formation during immersion in tris buffer at 37°C over up to seven days were investigated. Crystal phases formed in tris buffer were characterised using infra-red spectroscopy, X-ray diffraction and solid-state nuclear magnetic resonance.An increase in phosphate or fluoride content allowed for apatite formation at lower pH; fluoride enhanced apatite formation due to lower solubility of FAp compared to hydroxyapatite or HCA. High phosphate content glasses formed apatite significantly faster (within 6 hours) than low phosphate content glasses (within 3 days). In addition, an increase in phosphate content favoured apatite formation rather than fluorite (CaF 2 ). 19F MAS NMR showed the apatite formed by fluoride-containing glasses to be FAp, which makes these glasses of particular interest for dental applications. This study shows that by varying the phosphate content the reactivity and apatite formation of bioactive glasses can be controlled successfully.

show abstract

“…As the glass powders all had particle size distributions in the same range (results not shown), the greater pH increase found with increasing Sr substitution indicates an increase in dissolution rate of the glasses, which can be explained on the basis of the more weakly bonded and more expanded network observed previously [13]. A fixed amount of glass (75 mg) was used in these experiments; however, the atomic weight of Sr is 87 compared with 40 g mol 21 for Ca. As a result, the molar amount of glass decreased with increasing Sr substitution, and a reduced pH rise with increasing Sr would have been expected if the glasses all dissolved at the same rate.…”

Section: Ph Changes and Ion Release In Tris Buffermentioning

confidence: 99%

Influence of strontium for calcium substitution in bioactive glasses on degradation, ion release and apatite formation

Fredholm

Karpukhina

Brauer

et al. 2011

J. R. Soc. Interface.

165

139

View full text Add to dashboard Cite

Bioactive glasses are able to bond to bone through the formation of hydroxy-carbonate apatite in body fluids while strontium (Sr)-releasing bioactive glasses are of interest for patients suffering from osteoporosis, as Sr was shown to increase bone formation both in vitro and in vivo. A melt-derived glass series (SiO 2 -P 2 O 5 -CaO -Na 2 O) with 0 -100% of calcium (Ca) replaced by Sr on a molar base was prepared. pH change, ion release and apatite formation during immersion of glass powder in simulated body fluid and Tris buffer at 378C over up to 8 h were investigated and showed that substituting Sr for Ca increased glass dissolution and ion release, an effect owing to an expansion of the glass network caused by the larger ionic radius of Sr ions compared with Ca. Sr release increased linearly with Sr substitution, and apatite formation was enhanced significantly in the fully Sr-substituted glass, which allowed for enhanced osteoblast attachment as well as proliferation and control of osteoblast and osteoclast activity as shown previously. Studying the composition -structure-property relationship in bioactive glasses enables us to successfully design next-generation biomaterials that combine the bone regenerative properties of bioactive glasses with the release of therapeutically active Sr ions.

show abstract

Early stages of calcium-phosphate layer formation in bioglasses

Cited by 263 publications

References 10 publications

Fluoride-containing bioactive glasses: Effect of glass design and structure on degradation, pH and apatite formation in simulated body fluid

Fluoride-containing bioactive glasses: Effect of glass design and structure on degradation, pH and apatite formation in simulated body fluid

High phosphate content significantly increases apatite formation of fluoride-containing bioactive glasses

Influence of strontium for calcium substitution in bioactive glasses on degradation, ion release and apatite formation

Contact Info

Product

Resources

About