Ultra-wide band is one of the emerging indoor positioning technologies. In the application phase, accuracy and interference are important criteria of indoor positioning systems. Not only the method used in positioning, but also the algorithms used in improving the accuracy is a key factor. In this paper, we tried to eliminate the effects of off-set and noise in the data of the ultra-wide band sensor-based indoor positioning system. For this purpose, optimization algorithms and filters have been applied to the raw data, and the accuracy has been improved. A test bed with the dimensions of 7.35 m × 5.41 m and 50 cm × 50 cm grids has been selected, and a total of 27,000 measurements have been collected from 180 test points. The average positioning error of this test bed is calculated as 16.34 cm . Then, several combinations of algorithms are applied to raw data. The combination of Big Bang-Big Crunch algorithm for optimization, and then the Kalman Filter have yielded the most accurate results. Briefly, the average positioning error has been reduced from 16.34 cm to 7.43 cm . Key words: Indoor positioning, ultra-wide band sensors, optimization, big bang-big crunch algorithm, genetic algorithms, the Kalman filter (A-GPS) technology is a navigation system used on mobile devices that helps to identify a user's location via the base station's A-GPS address server [3]. The accuracy provided by the GPS in determining the outdoor location is between 3 m and 15 m , usually around 10 m . The accuracy that A-GPS provides in determining the outdoor location is about 15 m, while the interior is 50 m [3]. As can be seen from the accuracy values, these solutions are sufficient to determine the outdoor position, in other words, the position in the open space.On the other hand, given the fact that people now spend more than 80% of their time indoors, a suitable system for locating interior space is needed. Unfortunately, the use of GPS satellites in indoor location determination is not possible as GPS signals are weaken due to atmospheric delays, multi-paths, steel structures, roofs and building walls [1][2][3]. For this reason, efforts have been made to develop new technologies that allow reliable indoor location determination with high accuracy, low average positioning error over the past two decades.