Early suppression of basophil activation during allergen-specific immunotherapy by histamine receptor 2

Novak, Natalija; Mete, Nihal; Bußmann, Caroline; Maintz, Laura; Bieber, Thomas; Akdiş, Mübeccel; Zumkehr, Judith; Jutel, Marek; Akdiş, Cezmi A.

doi:10.1016/j.jaci.2012.04.039

Cited by 125 publications

(108 citation statements)

References 30 publications

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“…Although AIT reduces the allergic inflammation mediated by IgE-dependent mechanism over the time, a very early effect on basophil and mast cell activation status is observed just after the initiation of the therapeutic regimen, leading to a lower risk to develop anaphylactic manifestations [33][34][35]. The subjacent mechanism of basophil and mast cell desensitization has not been elucidated yet; however, some clues highlight this issue.…”

Section: Cellular and Molecular Mechanisms Of Aitmentioning

confidence: 99%

“…The levels of mRNA and FcεRI cell-surface expression decreased in basophil cells from patients submitted to venom immunotherapy, indicating that the reduction in FcεRI expression contributes to the phenomenon of the early basophil desensitization observed after AIT [37,38]. On the other hand, AIT also provokes an allergen-mediated upregulation of the type 2 histamine receptor (H2R) gene, which was associated with the suppression of FcεRI-mediated basophil activation, inducing a tolerogenic response (Figure 2) [34,39]. The engagement of H2R with its agonists prevents further histamine and leukotriene releasing as well as IL-4 and IL-8 production by basophil cells [34].…”

Section: Cellular and Molecular Mechanisms Of Aitmentioning

confidence: 99%

“…On the other hand, AIT also provokes an allergen-mediated upregulation of the type 2 histamine receptor (H2R) gene, which was associated with the suppression of FcεRI-mediated basophil activation, inducing a tolerogenic response (Figure 2) [34,39]. The engagement of H2R with its agonists prevents further histamine and leukotriene releasing as well as IL-4 and IL-8 production by basophil cells [34]. The molecular mechanism involved in H2R-dependent basophil desensitization is supposed to be mediated by the cAMP pathway because the stimulation with H2R agonist or with a direct cAMP inducer was able to inhibit the FcεRI-mediated basophil activation [34].…”

Section: Cellular and Molecular Mechanisms Of Aitmentioning

confidence: 99%

“…The engagement of H2R with its agonists prevents further histamine and leukotriene releasing as well as IL-4 and IL-8 production by basophil cells [34]. The molecular mechanism involved in H2R-dependent basophil desensitization is supposed to be mediated by the cAMP pathway because the stimulation with H2R agonist or with a direct cAMP inducer was able to inhibit the FcεRI-mediated basophil activation [34]. In this way, the increase of concentration of cAMP activates PKA (Protein Kinase A, the principal intracellular target of cAMP), which in turn decreases the intracellular calcium influx, thus preventing FcεRI-dependent basophil and mast cell degranulation [22].…”

Section: Cellular and Molecular Mechanisms Of Aitmentioning

confidence: 99%

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Allergen-Specific Immunotherapy Follow-Up by Measuring Allergen-Specific IgG as an Objective Parameter

Taketomi¹,

Miranda²,

Júnior³

et al. 2017

Immunotherapy - Myths, Reality, Ideas, Future

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The clinical efficacy of the allergen-specific immunotherapy (AIT) has been well-documented using inhalant or hymenoptera-derived allergens in atopic patients with corresponding specific IgE antibodies. AIT is considered as the unique treatment that is capable of modifying the natural course of the allergic disease because it induces a variety of immunological mechanisms, with emphasis in the production of blocking IgG antibodies by IL-10-stimulated B cells due to the generation of Treg, Breg, or even Th2 cells. Thus, the measurement of specific IgG subclasses, particularly IgG4, to the crude extract or more importantly to allergen components, might be a useful and potential tool to follow-up objectively the patients undergoing AIT in addition to clinical parameters. In this chapter, the authors have emphasized a very sensitive and highly specific reverse ELISA, developed by them, to measure IgG subclasses directed to clinically relevant natural allergens that are undoubtedly better when compared to those obtained with recombinant counterparts. Such a technique may produce more authentic results taking into account the IgG subclass binding capacity to a particular allergen and might be a valuable and alternative method for monitoring activation of tolerance-inducing mechanisms in patients under AIT.

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Section: Cellular and Molecular Mechanisms Of Aitmentioning

confidence: 99%

Section: Cellular and Molecular Mechanisms Of Aitmentioning

confidence: 99%

Section: Cellular and Molecular Mechanisms Of Aitmentioning

confidence: 99%

Section: Cellular and Molecular Mechanisms Of Aitmentioning

confidence: 99%

See 2 more Smart Citations

Allergen-Specific Immunotherapy Follow-Up by Measuring Allergen-Specific IgG as an Objective Parameter

Taketomi¹,

Miranda²,

Júnior³

et al. 2017

Immunotherapy - Myths, Reality, Ideas, Future

View full text Add to dashboard Cite

show abstract

“…Several hypotheses to explain the mechanisms underlying cell hyporesponsiveness were proposed, such as exhaustion of stored mediators caused by repetitive stimulation (taquiphylaxis), Syk and Lyn consumption, FceRI internalization, activation of inhibitory receptors, and suboptimal doses of antigen unable to cross-link FceRI receptors. It has been established that activating signals are counterbalanced by inhibition signals and a number of inhibitory receptors have been identified on mast cells [8][9][10][11]. Some of these, such as FcγRII and LILRB4 (GP49), are immunoreceptors signalizing throw tyrosine-based inhibitory motifs (ITIMs) that recruit protein tyrosine phosphatases, which are negative regulators of FceRI-mediated mast cell responses [12].…”

Section: Introductionmentioning

confidence: 99%

Rapid Desensitization in Immediate Hypersensitivity Reaction to Drugs

Giavina‐Bianchi

Aun

Galvão

et al. 2015

Curr Treat Options Allergy

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Heterogeneous validity of daily data on symptoms of seasonal allergic rhinitis recorded by patients using the e‐diary AllergyMonitor®

Dramburg

Perna

Fraia

et al. 2021

Clinical & Translational All

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Background Patient‐generated symptom and medication scores are essential for diagnostic and therapeutic decisions in seasonal allergic rhinitis (SAR). Previous studies have shown solid consistencies between different scores at population level in real‐life data and trials. For clinicians, the evaluation of individual data quality over time is essential to decide whether to rely on these data in clinical decision‐making. Objective To analyze the consistency of different symptom (SS) and symptom medication scores (SMSs) at individual level in two study cohorts with different characteristics and explore individual patient trajectories over time. Methods Within the pilot phase of the @IT.2020 project on diagnostic synergy of mobile health and molecular IgE assessment in patients with SAR, we analyzed data of 101 children and 93 adults with SAR and instructed them to record their symptoms and medication intake daily via the mobile app AllergyMonitor®. We then assessed the correlation between different SMS and a visual analogue scale (VAS) on the impact of allergy symptoms on daily life at population and individual level. Results At population level, the Rhinoconjunctivitis total symptom score (RTSS) correlated better with VAS than the combined symptom and medication score (CSMS). At individual level, consistency among RTSS and VAS was highly heterogeneous and unrelated to disease severity or adherence to recording. Similar heterogeneity was observed for CSMS and VAS. Conclusions The correlation of clinical information provided by different disease severity scores based on data collected via electronic diaries (e‐diaries), is sufficient at population level, but broadly heterogeneous for individual patients. Consistency of the recorded data must be examined for each patient before remotely collected information is used for clinical decision making.

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Early suppression of basophil activation during allergen-specific immunotherapy by histamine receptor 2

Cited by 125 publications

References 30 publications

Allergen-Specific Immunotherapy Follow-Up by Measuring Allergen-Specific IgG as an Objective Parameter

Allergen-Specific Immunotherapy Follow-Up by Measuring Allergen-Specific IgG as an Objective Parameter

Rapid Desensitization in Immediate Hypersensitivity Reaction to Drugs

Heterogeneous validity of daily data on symptoms of seasonal allergic rhinitis recorded by patients using the e‐diary AllergyMonitor®

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