Early suppression of excitability in subcortical band heterotopia modifies epileptogenesis in rats

Hardy, Delphine; Buhler, Emmanuelle; Suchkov, D. S.; Vinck, Antonin; Fortoul, Aurélien; Watrin, Françoise; Represa, Alfonso; Minlebaev, Marat; Manent, Jean-Bernard

doi:10.1016/j.nbd.2023.106002

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…Although we did not perform longitudinal EEG recordings, we never saw evidence of behavioral seizure manifestations up to the ages we studied here (P12-15). Longitudinal electrographic recordings aimed at identifying the first signs of network dysfunction until the first seizures appear and become mature, as we recently did in a rat model of SBH, 88 would be crucial to relate the age-dependent progression of epilepsy to specific morpho-electric signatures, if such signatures exist. Finally, how relevant are observations made in rodent models to the human pathology?…”

Section: Discussionmentioning

confidence: 99%

Distinct subtypes of grey matter heterotopia show subtype-specific morpho-electric neuronal properties and dynamics of epileptiform activity in mice

Vermoyal,

Hardy,

Goirand-Lopez

et al. 2023

Preprint

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Grey matter heterotopia (GMH) are neurodevelopmental disorders associated with abnormal cortical function and epilepsy. Subcortical band heterotopia (SBH) and periventricular nodular heterotopia (PVNH) are two well-recognized GMH subtypes in which neurons are misplaced, either forming nodules lining the ventricles in PVNH, or forming bands in the white matter in SBH. Although both PVNH and SBH are commonly associated with epilepsy, it is unclear whether these two GMH subtypes differ in terms of pathological consequences or, on the contrary, share common altered mechanisms. Here, we studied two faithful preclinical models of SBH and PVNH, and performed a systematic comparative assessment of the physiological and morphological diversity of heterotopia neurons, as well as the dynamics of epileptiform activity and input connectivity. We uncovered a complex set of altered properties, including both common and distinct physiological and morphological features across heterotopia subtypes, and associated with specific dynamics of epileptiform activity. Taken together, these results suggest that pro-epileptic circuits in GMH are, at least in part, composed of neurons with distinct, subtype-specific, physiological and morphological properties depending on the heterotopia subtype. Our work supports the notion that GMH represent a complex set of disorders, associating both shared and diverging pathological consequences, and contributing to forming epileptogenic networks with specific properties. A deeper understanding of these properties may help to refine current GMH classification schemes by identifying morpho-electric signatures of GMH subtypes, and potentially inform new treatment strategies.

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Section: Discussionmentioning

confidence: 99%

Distinct subtypes of grey matter heterotopia show subtype-specific morpho-electric neuronal properties and dynamics of epileptiform activity in mice

Vermoyal,

Hardy,

Goirand-Lopez

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Grey matter heterotopia subtypes show specific morpho-electric signatures and network dynamics

Vermoyal,

Hardy,

Goirand-Lopez

et al. 2023

Brain

View full text Add to dashboard Cite

Grey matter heterotopia (GMH) are neurodevelopmental disorders associated with abnormal cortical function and epilepsy. Subcortical band heterotopia (SBH) and periventricular nodular heterotopia (PVNH) are two well-recognized GMH subtypes in which neurons are misplaced, either forming nodules lining the ventricles in PVNH, or forming bands in the white matter in SBH. Although both PVNH and SBH are commonly associated with epilepsy, it is unclear whether these two GMH subtypes differ in terms of pathological consequences or, on the contrary, share common altered mechanisms. Here, we studied two robust preclinical models of SBH and PVNH, and performed a systematic comparative assessment of the physiological and morphological diversity of heterotopia neurons, as well as the dynamics of epileptiform activity and input connectivity. We uncovered a complex set of altered properties, including both common and distinct physiological and morphological features across heterotopia subtypes, and associated with specific dynamics of epileptiform activity. Taken together, these results suggest that pro-epileptic circuits in GMH are, at least in part, composed of neurons with distinct, subtype-specific, physiological and morphological properties depending on the heterotopia subtype. Our work supports the notion that GMH represent a complex set of disorders, associating both shared and diverging pathological consequences, and contributing to forming epileptogenic networks with specific properties. A deeper understanding of these properties may help to refine current GMH classification schemes by identifying morpho-electric signatures of GMH subtypes, to potentially inform new treatment strategies.

show abstract

Early suppression of excitability in subcortical band heterotopia modifies epileptogenesis in rats

Cited by 2 publications

References 35 publications

Distinct subtypes of grey matter heterotopia show subtype-specific morpho-electric neuronal properties and dynamics of epileptiform activity in mice

Distinct subtypes of grey matter heterotopia show subtype-specific morpho-electric neuronal properties and dynamics of epileptiform activity in mice

Grey matter heterotopia subtypes show specific morpho-electric signatures and network dynamics

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