Early symptoms of brain tumours

Davies, Elizabeth; Clarke, Callisia N.

doi:10.1136/jnnp.2003.033308

Cited by 40 publications

(28 citation statements)

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“…Children typically present with less complete or clear symptomatology than adults, 11 although this may partly reflect underrecognition of nonspecific cognitive and personality change in adults. 12 Brain imaging of young children often requires anaesthesia and may therefore not be readily available.…”

mentioning

confidence: 99%

The presenting features of brain tumours: a review of 200 cases

Wilne

Ferris²,

Nathwani³

et al. 2006

Archives of Disease in Childhood

183

155

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Results: The commonest first presenting symptoms were headache (41%), vomiting (12%), unsteadiness (11%), visual difficulties (10%), educational or behavioural problems (10%), and seizures (9%). The commonest symptoms occurring at any time were headache (56%), vomiting (51%), educational or behavioural problems (44%), unsteadiness (40%), and visual difficulties (38%). Neurological signs were present at diagnosis in 88%: 38% had papilloedema, 49% cranial nerve abnormalities, 48% cerebellar signs, 27% long tract signs, 11% somatosensory abnormalities, and 12% a reduced level of consciousness. The median symptom interval was 2.5 months (range 1 day to 120 months). A short symptom interval was significantly associated with high grade tumours and patient age of 3 years or younger. Conclusions: The well known predominance of headache in children with CNS tumours is confirmed. Visual, behavioural, and educational symptoms were also prominent. With the exception of seizures, every initial symptom was accompanied by other symptoms or signs by the time of diagnosis. Questions about visual symptoms and educational or behavioural difficulties, as well as the more widely recognised symptoms of raised intracranial pressure and motor dysfunction, are important in the diagnosis of brain tumours, as are vision assessment and the appropriate plotting of growth and head size.

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mentioning

confidence: 99%

The presenting features of brain tumours: a review of 200 cases

Wilne

Ferris²,

Nathwani³

et al. 2006

Archives of Disease in Childhood

183

155

View full text Add to dashboard Cite

show abstract

“…In 183 adult patients with primary and metastatic brain tumors, only 8% had isolated headache at presentation and all developed other symptoms within 11 weeks [11]. Similarly, Davies and Clarke [8] reported that 48 of 92 patients with primary brain tumors had headache at diagnosis but only two had no other symptoms.…”

Section: Epidemiologymentioning

confidence: 98%

“…The reported prevalence of headache ranges from 48% to 71% in unselected series [4][5][6][7][8]. Headache is less common at the extremes of patient ages.…”

Section: Epidemiologymentioning

confidence: 99%

Headache and brain tumors

Kirby

2007

Curr Neurol Neurosci Rep

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We review the current state of knowledge regarding headache and brain tumors. The epidemiology of this clinically relevant area is highlighted along with general clinical features of headache disorders seen in brain tumor patients. Some rarer clinical presentations are noted, particularly in relationship to the newly described trigeminal autonomic cephalalgias, as well as the relationships of headache to pituitary tumors and paroxysmal and positional headaches. Headaches as a result of brain tumor therapy are noted, as is the important area of treatment of headaches in patients with central nervous system neoplasms of a primary or secondary nature.

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“…Concerns about delayed diagnosis are also a common theme among patients. 1 Although consensus may be lacking about optimal treatment in certain situations such as low-grade glioma, early identification at the least permits monitoring, and at best may improve prognosis. However, the best method for the early identification of central nervous system (CNS) tumours remains uncertain, as the possible presentations are diverse and overlap with many other neurological conditions.…”

mentioning

confidence: 99%

Referral guidelines for suspected central nervous system or brain tumours

Larner

2006

Journal of Neurology, Neurosurgery & Psychiatry

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Early symptoms of brain tumours

Cited by 40 publications

References 1 publication

The presenting features of brain tumours: a review of 200 cases

The presenting features of brain tumours: a review of 200 cases

Headache and brain tumors

Referral guidelines for suspected central nervous system or brain tumours

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