Early trauma and familial risk in the development of the extended psychosis phenotype in adolescence

Wigman, Johanna T. W.; Winkel, Ruud van; Ormel, Johan; Verhulst, Frank C.; Os, Jim van; Vollebergh, Wilma

doi:10.1111/j.1600-0447.2012.01857.x

Cited by 56 publications

(54 citation statements)

References 61 publications

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“…These findings are in line with previous studies reporting that the effect of childhood trauma on later experience of psychotic symptoms was independent of proxy genetic liability to psychosis [5,[9][10][11]. Overall, these results suggest that biological and environmental risk factors are both important in the etiology of psychosis but the effects of some forms of childhood adversity act largely independently of pre-existing genetic liability to increase risk of psychosis.…”

Section: Discussionsupporting

confidence: 91%

“…In the absence of direct genetic data, researchers have used familial aggregation of psychiatric disorders as proxy measures of genetic risk. However, most of the studies involving familial liability have been restricted to general population samples and results are still controversial [4][5][6][7][8][9]. Only two studies have investigated the interplay between childhood adversity and familial risk for mental health problems in a first-episode psychosis sample [10,11] and found no evidence of gene-environment interaction.…”

Section: Introductionmentioning

confidence: 99%

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133. Interplay Between Schizophrenia Polygenic Risk Score and Childhood Adversity in First-Presentation Psychotic Disorder: A Pilot Study

Trotta

Iyegbe

Forti

et al. 2017

Schizophrenia Bulletin

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A history of childhood adversity is associated with psychotic disorder, with an increase in risk according to number or severity of exposures. However, it is not known why only some exposed individuals go on to develop psychosis. One possibility is pre-existing genetic vulnerability. Research on gene-environment interaction in psychosis has primarily focused on candidate genes, although the genetic effects are now known to be polygenic. This pilot study investigated whether the effect of childhood adversity on psychosis is moderated by the polygenic risk score for schizophrenia (PRS). Data were utilised from the Genes and Psychosis (GAP) study set in South London, UK. The GAP sample comprises 285 first-presentation psychosis cases and 256 unaffected controls with information on childhood adversity. We studied only white subjects (80 cases and 110 controls) with PRS data, as the PRS has limited predictive ability in patients of African ancestry. The occurrence of childhood adversity was assessed with the Childhood Experience of Care and Abuse Questionnaire (CECA.Q) and the PRS was based on genome-wide meta-analysis results for schizophrenia from the Psychiatric Genomics Consortium. Higher schizophrenia PRS and childhood adversities each predicted psychosis status. Nevertheless, no evidence was found for interaction as departure from additivity, indicating that the effect of polygenic risk scores on psychosis was not increased in the presence of a history of childhood adversity. These findings are compatible with a multifactorial threshold model in which both genetic liability and exposure to environmental risk contribute independently to the etiology of psychosis.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

133. Interplay Between Schizophrenia Polygenic Risk Score and Childhood Adversity in First-Presentation Psychotic Disorder: A Pilot Study

Trotta

Iyegbe

Forti

et al. 2017

Schizophrenia Bulletin

View full text Add to dashboard Cite

show abstract

“…Furthermore, individuals with psychotic experiences have been shown to have significantly more exposure to childhood trauma (Arseneault et al, 2011;Fisher et al, 2012;Freeman and Fowler, 2009;Galletly et al, 2011;Janssen et al, 2004;Kelleher et al, 2013c;Saha et al, 2011b;Scott et al, 2007;Wigman et al, 2012b), something that might also contribute to long term dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Psychotic experiences in the population: Association with functioning and mental distress

Kelleher

Wigman

Harley

et al. 2015

Schizophrenia Research

122

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“…Ailevi yatkınlık ile CAPE pozitif psikotik yaşan-tılar arasında doğrudan ilişki bulunmaktadır (Lataster ve ark. 2009, Wigman ve ark. 2012b).…”

Section: Bulgularunclassified

Psychotic Experiences in the Adaptation Process to a New Social Environment

Mısır¹,

Özsoydan²,

Artuk³

et al. 2016

Turkish Journal of Psychiatry

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Early trauma and familial risk in the development of the extended psychosis phenotype in adolescence

Abstract: The development and persistence of subthreshold psychotic symptoms may be conditional on non-interacting proxy genetic and environmental influences.

Cited by 56 publications

References 61 publications

133. Interplay Between Schizophrenia Polygenic Risk Score and Childhood Adversity in First-Presentation Psychotic Disorder: A Pilot Study

133. Interplay Between Schizophrenia Polygenic Risk Score and Childhood Adversity in First-Presentation Psychotic Disorder: A Pilot Study

Psychotic experiences in the population: Association with functioning and mental distress

Psychotic Experiences in the Adaptation Process to a New Social Environment

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