Early Treatment Initiation Improves Outcomes in Nevus of Ota: A 10-Year Retrospective Study

Achavanuntakul, Petchlada; Manuskiatti, Woraphong; Wanitphakdeedecha, Rungsima; Jantarakolica, Tatre

doi:10.1007/s40257-021-00637-0

Cited by 8 publications

(11 citation statements)

References 31 publications

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“…Tis patient chose the LF-QSNY laser, and the lesion was completely cleared; however, the relapse was on the PSAL side. Reported recurrence rate after high-fuence laser treatment was 0.6-1.2% [10], but higher recurrence was reported in younger patients with a rate of 15.4% [28]. Te possible explanation for this relapse happened only on the PSAL side may be that the melanin-defcient melanocytes after the PSAL laser gradually accumulated melanin which would exaggerate pigment and trigger recurrence after complete clearance,while frequent and multiple LF-QSNY laser irradiation cumulates phototoxic damage on melanocytes, which causes a decrease in melanogenesis and atrophy of melanocyte dendrites [29,30].…”

Section: Discussionmentioning

confidence: 97%

“…Te consistency of assessment among diferent observers was analyzed by the intraclass correlation coefcient (ICC) and was defned as follows: poor, ICC ≤ 0.50; moderate, 0.50 < ICC ≤ 0.75; good, 0.75 < ICC ≤ 0.9; excellent, ICC > 0.9. In addition, Fisher's exact test was used to analyze the correlation between efect and age, gender, lesion color, sclera pigmentation, and Tanino classifcation [9,10]. Diference was defned as statistically signifcant when P < 0.05.…”

Section: Discussionmentioning

confidence: 99%

“…Also, adopting LF-QSNY leads to faster recovery. Te mean treatment sessions for the LF-QSNY were 15.62 (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24), which means patients can fnish the session within four months. While the mean treatment sessions for PSAL were two to fve, usually threeto-six-month intervals between sessions were recommended, which would take the mean at least 6 months for PSAL treatments and may even be longer than 30 months [27].…”

Section: Discussionmentioning

confidence: 99%

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Low-Fluence Q-Switched Nd: YAG Laser (LF-QSNY) May Be a Better Choice for the Treatment of Early Nevus of Ota: A Prospective Self-Controlled Trial of LFQS and Picosecond Alexandrite Laser

Zhou,

Zhu,

Cen

et al. 2024

Dermatologic Therapy

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Background. Low-fluence Q-switched Nd: YAG laser (LF-QSNY) and picosecond 755 nm alexandrite laser (PSAL) have shown superiority in the treatment of nevus of Ota (NO). Objective. To compare the efficacy and safety of PSAL and LF-QSNY in the treatment of NO. Methods. 15 patients randomly underwent split-lesion treatment of the two lasers within three months. The visual analogue scale (VAS) was used to evaluate the efficacy outcomes. The patient’s preferences, recurrence rate, and adverse events were also documented. Results. Fifteen patients with 34 lesions finished the trial. Lesions, operated with LF-QSNY and PSAL, reached VAS scores of 3.47 ± 0.67 and 3.51 ± 0.87, respectively (P>0.05). Most significant improvement in LF-QSNY was achieved after the first session (VAS = 1.84). One (6.67%) patient experienced a relapse on the PSAL side. Temporary hypopigmentation and hyperpigmentation mainly occurred on the PSAL side. Patients under five years demonstrated superior efficacy (3.81 ± 0.47 vs 3.08 ± 0.66, P=0.046) than those over with the treatment of LF-QSNY. Limitations. Limited sample and lack of objective evaluation. Conclusion. The difference between the LF-QSNY and PSAL in the treatment of NO was statistically insignificant, while LF-QSNY may be a better choice for the treatment of early NO. This trial is registered with ChiCTR1900022690.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Low-Fluence Q-Switched Nd: YAG Laser (LF-QSNY) May Be a Better Choice for the Treatment of Early Nevus of Ota: A Prospective Self-Controlled Trial of LFQS and Picosecond Alexandrite Laser

Zhou,

Zhu,

Cen

et al. 2024

Dermatologic Therapy

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“…755 nm picosecond Alexandrite has demonstrated superiority to 755 nm Q-switched Alexandrite in terms of treatments needed, as well as posttreatment erythema and duration of postinflammatory hyperpigmentation after treatment [24–27]. Rates of recurrence after treatment are variable and depend on the number of treatments and clearance achieved, but clearance of 85% or higher is associated with a lower risk of recurrence [28 ▪ ]. New literature suggests that earlier treatment initiation before the age of 5 improves outcomes and minimizes the risk of recurrence (Fig.…”

Section: Pigmented Lesionsmentioning

confidence: 99%

“…New literature suggests that earlier treatment initiation before the age of 5 improves outcomes and minimizes the risk of recurrence (Fig. 3) [28 ▪ ]. However, lasers used to treat pigment are more difficult to use on uncooperative patients than PDL, and consideration of the risks and benefits of treatment under local versus general anesthesia needs to be weighed.…”

Section: Pigmented Lesionsmentioning

confidence: 99%

Update on lasers in pediatric dermatology: how primary care providers can help patients and families navigate appropriate treatment options and timelines

Osborn

Nieman

2023

Current Opinion in Pediatrics

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Purpose of review The use of lasers in pediatric dermatology is well established, but recent literature has expanded the evidence for specific timelines of treatment. Additionally, new devices and combinations with medical therapy have improved outcomes and treatment options for various conditions. Recent findings Pulsed dye laser remains the first-line laser for vascular lesions. Recent guidelines support early initiation of laser treatment in port-wine birthmarks to optimize outcomes. For hemangiomas, laser treatment can offer a meaningful addition to oral propranolol therapy. Lasers with shorter wavelengths offer improved outcomes with decreased downtime for pigmented lesions. General anesthesia in the pediatric population continues to be a controversial topic, and the decision to perform laser under general versus topical anesthesia requires discussion with family of risks and benefits. Summary Primary care providers can benefit their patients by prompt referral to dermatology for discussion of laser treatment. Port-wine birthmarks require referral in the first weeks of life so that laser treatment can be initiated if appropriate. Although many dermatologic conditions cannot be completely cleared or cured with laser, treatment can offer meaningful outcomes and benefit for patients and families.

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Picosecond alexandrite laser treatment of nevus of Ota in children

Zhao,

Yang,

Shi

et al. 2024

Lasers Surg Med

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BackgroundThe picosecond alexandrite laser has been safely and effectively used to treat the nevus of Ota in adults. However, limited data are available for children.ObjectiveTo investigate the efficacy, safety, and correlative influencing factors of a 755nm picosecond alexandrite laser in the treatment of nevus of Ota in children.MethodsWe retrospectively analyzed Chinese children with nevus of Ota who received a 755nm picosecond alexandrite laser treatment in a tertiary dermatological hospital.ResultA total of 305 pediatric patients received an average of two treatments achieving an average of 79% pigment clearance. After the first treatment, 22 patients achieved complete clearance (95%–100%), and 72 patients achieved excellent response (75%–94%), with an average initial efficacy of 63% lesion clearance. Treatment at an early age achieved better initial efficacy (0‐ to 12‐month group >1‐ to 6‐year group, 6‐ to 12‐year group). And 0‐ to 12‐month group achieved better final efficacy. More treatment sessions also increased the final efficacy. Both initial efficacy and final efficacy were better when treating a darker lesion. The incidence of complications was 12.1%, with 10.8% being post‐inflammatory hyperpigmentation and 1.3% being hypopigmentation. The rate of recurrence was 6.6%.LimitationRetrospective study.ConclusionA 755nm picosecond alexandrite laser is safe and effective in treating nevus of Ota in children. Younger to initiate treatment, darker lesions, and more treatments are positively associated with better pigmentation clearance.

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Early Treatment Initiation Improves Outcomes in Nevus of Ota: A 10-Year Retrospective Study

Cited by 8 publications

References 31 publications

Low-Fluence Q-Switched Nd: YAG Laser (LF-QSNY) May Be a Better Choice for the Treatment of Early Nevus of Ota: A Prospective Self-Controlled Trial of LFQS and Picosecond Alexandrite Laser

Low-Fluence Q-Switched Nd: YAG Laser (LF-QSNY) May Be a Better Choice for the Treatment of Early Nevus of Ota: A Prospective Self-Controlled Trial of LFQS and Picosecond Alexandrite Laser

Update on lasers in pediatric dermatology: how primary care providers can help patients and families navigate appropriate treatment options and timelines

Picosecond alexandrite laser treatment of nevus of Ota in children

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