2023
DOI: 10.1002/dmrr.3711
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Early treatment with dipeptidyl‐peptidase 4 inhibitors reduces glycaemic variability and delays insulin initiation in type 2 diabetes: A propensity score‐matched cohort study

Johnny T. K. Cheung,
Aimin Yang,
Hongjiang Wu
et al.

Abstract: AimsTo examine whether early treatment intensification using dipeptidyl‐peptidase 4 inhibitors (DPP4i) delays insulin initiation in Chinese patients diagnosed with type 2 diabetes for less than 5 years.Materials and MethodsIn a territory‐wide prospective cohort study, patients with type 2 diabetes initiating DPP4i at diabetes duration <2 years (early intensification) and 3–5 years (late intensification) were matched using 1:1 propensity‐score matching (n = 908 in each arm). We used Cox regression to compare… Show more

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Cited by 4 publications
(2 citation statements)
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“…The availability of many oral glucose-lowering drugs can inadvertently delay insulin treatment. Given the legacy effect of early glycemic control on increasing glycemic durability [56,57] and reducing long-term complications [58][59][60] in both type 1 and type 2 diabetes, misdiagnosis of LADA should be avoided.…”
Section: Latent Autoimmune Diabetes In Adultsmentioning
confidence: 99%
See 1 more Smart Citation
“…The availability of many oral glucose-lowering drugs can inadvertently delay insulin treatment. Given the legacy effect of early glycemic control on increasing glycemic durability [56,57] and reducing long-term complications [58][59][60] in both type 1 and type 2 diabetes, misdiagnosis of LADA should be avoided.…”
Section: Latent Autoimmune Diabetes In Adultsmentioning
confidence: 99%
“…An estimated 50% of beta-cell function might have been lost at the time of diagnosis of diabetes [121] . Early optimization of glycemic control could restore beta-cell function [122] and delay treatment escalation [56,57] . These data support the use of biomarkers to improve the precision of diagnosis and treatment to preserve beta-cell function [123] .…”
Section: Using Biogenetic Markers To Increase the Precision Of Diagno...mentioning
confidence: 99%