Early tumor detection afforded by in vivo imaging of near-infrared II fluorescence

Tao, Zhimin; Dang, Xiangnan; Huang, Xing; Muzumdar, Mandar Deepak; Xu, Eric S.; Bardhan, Neelkanth M.; Song, Hang; Qi, Ruogu; Yu, Yingjie; Li, Ting; Wei, Wei; Wyckoff, Jeffrey; Birrer, Michael J.; Belcher, Angela M.; Ghoroghchian, P. Peter

doi:10.1016/j.biomaterials.2017.04.046

Cited by 104 publications

(85 citation statements)

References 73 publications

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“…They demonstrated the dynamic process of Ag 2 S QD‐labelled MSC biodistribution and homing in response to SDF‐1α on the cutaneous wound healing . Considering high sensitivity and resolution at the cellular level for optical imaging in the SWIR region, researchers also can evaluate the tumour cell deposits in its early stages in addition to monitoring of the dynamic cellular behaviour . For this reason, Tao et al have investigated the growth of the tumour in the early stage in the small animal model.…”

Section: Bioimaging In Swir Regionmentioning

confidence: 99%

Optical fluorescence imaging with shortwave infrared light emitter nanomaterials for in vivo cell tracking in regenerative medicine

Fath‐Bayati

Vasei

Sharif‐Paghaleh

2019

J Cellular Molecular Medi

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In vivo tracking and monitoring of adoptive cell transfer has a distinct importance in cell‐based therapy. There are many imaging modalities for in vivo monitoring of biodistribution, viability and effectiveness of transferred cells. Some of these procedures are not applicable in the human body because of low sensitivity and high possibility of tissue damages. Shortwave infrared region (SWIR) imaging is a relatively new technique by which deep biological tissues can be potentially visualized with high resolution at cellular level. Indeed, scanning of the electromagnetic spectrum (beyond 1000 nm) of SWIR has a great potential to increase sensitivity and resolution of in vivo imaging for various human tissues. In this review, molecular imaging modalities used for monitoring of biodistribution and fate of administered cells with focusing on the application of non‐invasive optical imaging at shortwave infrared region are discussed in detail.

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Section: Bioimaging In Swir Regionmentioning

confidence: 99%

Optical fluorescence imaging with shortwave infrared light emitter nanomaterials for in vivo cell tracking in regenerative medicine

Fath‐Bayati

Vasei

Sharif‐Paghaleh

2019

J Cellular Molecular Medi

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“…[17] They engineered the donors to acquire a high QY in NIR II small molecule dyes using benzo(1,2-c:4,5c )bis(1,2,5)thiadiazole (BBTD) as the acceptor and fluorine as a shielding unit. [15] Copyright 2017, Elsevier Ltd. E) Images taken of a representative mouse at 2 weeks after implantation of luciferase-/red fluorescent protein-positive OVCAR-8 ovarian cancer cells and 72 h after IP injection of untargeted luminescence probes. A) Wavelength for bioimaging.…”

Section: Optimization Of Small Molecule Dyesmentioning

confidence: 99%

“…Using octylthiophene as the first donor and thiophene as the second donor, the developed small molecule dye www.advancedsciencenews.com www.advtherap.com Figure 1. [15] Copyright 2017, Elsevier Ltd. B) Extinction spectrum (black curve) and scattering spectrum (red curve) of 1% Intralipid in water with a path length of 1 mm measured with a UV-vis-NIR spectrometer, as well as a reduced scattering coefficient profile of 1% Intralipid (blue curve).…”

Section: Optimization Of Small Molecule Dyesmentioning

confidence: 99%

Recent Advance in Near‐Infrared (NIR) Imaging Probes for Cancer Theranostics

Liu

Jia

Zhou

2018

Advanced Therapeutics

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With the advantages of low biofluid scattering and minimal absorbance, light in a second near-infrared window (NIR II, 1000-1700 nm) either as a signal or as an excitation source is preferred for bioimaging and disease diagnosis, especially for cancer theranostics. Due to recent advances in chemical synthesis and imaging techniques, various NIR II probes have been evaluated for tumor luminescence image-guided cancer therapy and surgery. Furthermore, probes emitting optical, acoustic, or thermal signals under NIR II excitation have also been developed for upconversion luminescence, photoacoustic, and photothermal imaging of tumors. Herein, recent advances in the use of NIR II imaging probes in cancer theranostic applications are summarized along with future perspectives.

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“…Up to now, in most studies, NIR‐II imaging is limited to two‐dimensional (2D) projected wide‐field epi‐fluorescence imaging without the capability of gleaning three‐dimensional (3D) tissue structures deeply. NIR‐II imaging applications are commonly adopted for whole‐body small‐animal imaging experiments performed in wide‐field to visualize vasculatures or organs with relatively low resolution and no optical sectioning capability .…”

Section: Introductionmentioning

confidence: 99%

Three‐dimensional cellular imaging in thick biological tissue with confocal detection of one‐photon fluorescence in the near‐infrared II window

Wang

Chen

2019

Journal of Biophotonics

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Fluorescence imaging in the second near‐infrared optical window (NIR‐II, 900‐1700 nm) has become a technique of choice for noninvasive in vivo imaging in recent years. Greater penetration depths with high spatial resolution and low background can be achieved with this NIR‐II window, owing to low autofluorescence within this optical range and reduced scattering of long wavelength photons. Here, we present a novel design of confocal laser scanning microscope tailored for imaging in the NIR‐II window. We showcase the outstanding penetration depth of our confocal setup with a series of imaging experiments. HeLa cells labeled with PbS quantum dots with a peak emission wavelength of 1276 nm can be visualized through a 3.5‐mm‐thick layer of scattering medium, which is a 0.8% Lipofundin solution. A commercially available organic dye IR‐1061 (emission peak at 1132 nm), in its native form, is used for the first time, as a NIR‐II fluorescence label in cellular imaging. Our confocal setup is capable of capturing optically sectioned images of IR‐1061 labeled chondrocytes in fixed animal cartilage at a depth up to 800 μm, with a superb spatial resolution of around 2 μm.

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Early tumor detection afforded by in vivo imaging of near-infrared II fluorescence

Cited by 104 publications

References 73 publications

Optical fluorescence imaging with shortwave infrared light emitter nanomaterials for in vivo cell tracking in regenerative medicine

Optical fluorescence imaging with shortwave infrared light emitter nanomaterials for in vivo cell tracking in regenerative medicine

Recent Advance in Near‐Infrared (NIR) Imaging Probes for Cancer Theranostics

Three‐dimensional cellular imaging in thick biological tissue with confocal detection of one‐photon fluorescence in the near‐infrared II window

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