Early Use of Recombinant Factor VIIa Improves Mean Arterial Pressure and May Potentially Decrease Mortality in Experimental Hemorrhagic Shock: A Pilot Study

Lynn, Mauricio; Jerokhimov, Igor; Jewelewicz, Dory; Popkin, Charles A.; Johnson, Edward W.; Rashid, Qammar; Brown, Margareth; Martinowitz, Uri; Cohn, Stephen M.

doi:10.1097/00005373-200204000-00016

Cited by 47 publications

(33 citation statements)

References 10 publications

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“…Recent data have shown that injection of recombinant activated FVII into swine increases mean arterial pressure. 35 FVII itself can also elicit cellular responses, such as angiogenesis 9 -11 and inflammation. 12,13,36 The blood coagulation cascade is initiated when cryptic tissue factor is expressed and exposed to circulating blood and binds plasma activated FVII.…”

Section: Discussionmentioning

confidence: 99%

Association Between Factor VII Polymorphisms and Blood Pressure

Sass

Blanquart²,

Morange³

et al. 2004

Hypertension

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Abstract-The purpose this study was to determine whether Arg353Gln and Ϫ323Del/Ins polymorphisms of factor VII (FVII) are related to blood pressure levels and hypertension. Subjects were drawn from the Stanislas Cohort, a longitudinal, familial French cohort examined twice since 1994. The "blood pressure study" included 1342 subjects free of medication use that could affect blood pressure. The "hypertension study" included 645 normotensive and 77 hypertensive adult subjects. Association with hypertension was also studied in 547 hypertensives enrolled in a clinical trial and in 624 normotensives drawn from the Stanislas Cohort. In the "blood pressure study," parents with the 353Gln or Ϫ323Ins allele had lower blood pressures than did noncarriers at each examination, independent of covariates (0 [1][2][3][4] and blood pressure (BP) and/or hypertension have been described. Association studies cannot establish whether abnormalities of rheology and coagulation occur as a consequence of the higher BP or whether these could be factors that contribute to high BP. However, data suggest that hemorheologic factors may be implicated in BP homeostasis. Thrombin, in addition to converting fibrinogen to fibrin, can interact with cell-surface receptors and induce several intracellular pathways. 5,6 Proangiogenic activities of thrombin have been described, 5 and thrombin can also modulate vascular tone 7 and have proinflammatory properties. 8 All of these factors can play a role in initiating and maintaining an elevation in BP.Factor VII (FVII) is a key factor in the coagulation cascade leading to the production of thrombin. FVII also elicits several cellular responses, such as angiogenesis 9 -11 and inflammation, 12,13 that may be related to hypertension, and associations between FVII and BP have been found. 14 -16 Genetic variations in the FVII gene, the Arg353Gln and the Ϫ323Del/Ins polymorphisms, have been related to FVII levels and coagulant activity. [17][18][19][20] An association between BP and the Arg353Gln polymorphism was described in a genetic isolate. 21 Therefore, the purpose of this study was to investigate the association of these 2 polymorphisms with BP levels and hypertension in a large, family-based population. Methods BP StudyThe study population was selected from the Stanislas Cohort 22 For the present study, 1342 individuals (657 men and 686 women from 424 families) were selected on the basis of the following criteria: (1) subjects were present at both the first (T0) and second (Tϩ5) examinations; (2) data from both examinations and information on FVII Arg353Gln and Ϫ323Del/Ins genotypes were available; and (3) at each visit, there was no indication of antihypertensive, lipidlowering, or anti-inflammatory drug use. Hypertension Studies Sample Group 1The normotensive subjects were drawn from the "blood pressure levels study" sample population. There were 295 fathers and 350 mothers with a systolic blood pressure (SBP)/diastolic blood pres-

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Section: Discussionmentioning

confidence: 99%

Association Between Factor VII Polymorphisms and Blood Pressure

Sass

Blanquart²,

Morange³

et al. 2004

Hypertension

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show abstract

“…All such studies, but one, have made use of liver injuries and associated hemorrhage. Four studies have involved normothermic pigs, an absence of hemodilution prior to injury, and did not supplement rFVIIa therapy with liver packing when liver injury was involved (Tables 8a,c; Lynn et al, 2002;Jeroukhimov et al, 2002;Schreiber et al, 2003;Pusateri et al, 2003). In one of these studies, resuscitation was used beginning 15 min postinjury (Schreiber et al, 2003), and at a rate lower than that used in the current study (100 mil/min).…”

Section: Discussionmentioning

confidence: 97%

Effect of Recombinant FVIIa in Hypothermic, Coagulopathic Pigs with Liver Injuries

Klemcke

Delgado

Holcomb

et al. 2005

The Journal of Trauma: Injury, Infection, and Critical Care

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“…Numerous anecdotal reports (Dutton, et al, 2004;Martinowitz, Kenet, Segal, & Lubetsky, 2001;O'Neill, et al, 2002) and animal models (Jeroukhimov, et al, 2002;Lynn, et al, 2002;Martinowitz, Holcomb, & Pusateri, 2001;Schreiber, et al, 2002) have generally supported the potential benefit of FVIIa to treat uncontrolled bleeding, and recent randomized trials indicated a trend toward higher survival among civilian trauma patients receiving FVIIa compared with standard care controls (Boffard, et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

The Role of Alternative Splicing in Breast Cancer Progression

Hertel¹

2007

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Early Use of Recombinant Factor VIIa Improves Mean Arterial Pressure and May Potentially Decrease Mortality in Experimental Hemorrhagic Shock: A Pilot Study

Abstract: Intravenous administration of rFVIIa early after induction of hemorrhage shortens prothrombin time and improves mean arterial pressure. A trend toward improved survival was observed.

Cited by 47 publications

References 10 publications

Association Between Factor VII Polymorphisms and Blood Pressure

Association Between Factor VII Polymorphisms and Blood Pressure

Effect of Recombinant FVIIa in Hypothermic, Coagulopathic Pigs with Liver Injuries

The Role of Alternative Splicing in Breast Cancer Progression

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