2012
DOI: 10.1186/bcr3174
|View full text |Cite
|
Sign up to set email alerts
|

Early vascular deficits are correlated with delayed mammary tumorigenesis in the MMTV-PyMT transgenic mouse following genetic ablation of the NG2 proteoglycan

Abstract: IntroductionThe neuron-glial antigen 2 (NG2) proteoglycan promotes pericyte recruitment and mediates pericyte interaction with endothelial cells. In the absence of NG2, blood vessel development is negatively impacted in several pathological models. Our goal in this study was to determine the effect of NG2 ablation on the early development and function of blood vessels in mammary tumors in the mammary tumor virus-driven polyoma middle T (MMTV-PyMT) transgenic mouse, and to correlate these vascular changes with … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

3
70
1

Year Published

2015
2015
2021
2021

Publication Types

Select...
5
1

Relationship

1
5

Authors

Journals

citations
Cited by 63 publications
(74 citation statements)
references
References 61 publications
3
70
1
Order By: Relevance
“…33 We have reported a similar loss of vascular localization of VEGF in B16F10 tumors grown in collagen VI null mice 11 and in MMTV-PyMT mammary tumors in NG2 null mice. 6 As in the case of Mac-NG2ko mice, the loss of vascular VEGF localization in these previous studies was correlated with greatly reduced basal lamina assembly. In each case, reduced vessel diameter is the most dramatic structural manifestation of decreased vascular VEGF localization.…”
Section: Discussionmentioning
confidence: 58%
See 4 more Smart Citations
“…33 We have reported a similar loss of vascular localization of VEGF in B16F10 tumors grown in collagen VI null mice 11 and in MMTV-PyMT mammary tumors in NG2 null mice. 6 As in the case of Mac-NG2ko mice, the loss of vascular VEGF localization in these previous studies was correlated with greatly reduced basal lamina assembly. In each case, reduced vessel diameter is the most dramatic structural manifestation of decreased vascular VEGF localization.…”
Section: Discussionmentioning
confidence: 58%
“…These are (a) the dramatic loss of N-cadherin expression by both pericytes and endothelial cells, (b) the marked loss of pericyte association with endothelial cells, and (c) the reduced diameter of tumor vessels. Changes in pericyte-endothelial cell interaction and in vessel diameter were previously noted in tumor vessels in germline NG2 null mice, 6,10 but were not detected in tumor vessels in PC-NG2ko mice.…”
Section: Discussionmentioning
confidence: 69%
See 3 more Smart Citations