Early Versus Delayed Postoperative Feeding After Major Gynaecological Surgery and its Effects on Clinical Outcomes, Patient Satisfaction, and Length of Stay: A Randomized Controlled Trial

Balayla, Jacques; Bujold, Emmanuel; Lapensée, Louise; Mayrand, Marie‐Hélène; Sansregret, A

doi:10.1016/s1701-2163(16)30073-1

Cited by 18 publications

(14 citation statements)

References 24 publications

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“…The sample size of the study was calculated by using the formula proposed by Woodword [22]. According to the results of a previous study by Balayla et al [4], the calculated sample size was 33 subjects per group. After adjustment for an 80% response rate and 90% expected eligibility rate (power = 80%, alpha level = 0.05), and to account for a 20% drop-out rate, a total of 110 subjects (55 subjects in each group) was needed.…”

Section: Sample Size Calculationmentioning

confidence: 99%

“…This is because of the utilization of energy which is converted from protein sources of the body (muscle) and promotes catabolism. Thus, patients experience weight loss and muscle mass loss postoperatively [4].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, most ERAS protocol studies were focused on postoperative clinical outcomes such as LOS, complication, and the readmission rate [4,5,15,16,19,20]. However, the role of the ERAS protocol in the changes of nutritional aspect (body composition) and functional status (handgrip strength) remain unclear.…”

Section: Introductionmentioning

confidence: 99%

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Impact of Enhanced Recovery after Surgery with Preoperative Whey Protein-Infused Carbohydrate Loading and Postoperative Early Oral Feeding among Surgical Gynecologic Cancer Patients: An Open-Labelled Randomized Controlled Trial

Ibrahim

Zaid

et al. 2020

Nutrients

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Enhanced Recovery after Surgery (ERAS) with sole carbohydrate (CHO) loading and postoperative early oral feeding (POEOF) shortened the length of postoperative (PO) hospital stays (LPOHS) without increasing complications. This study aimed to examine the impact of ERAS with preoperative whey protein-infused CHO loading and POEOF among surgical gynecologic cancer (GC) patients. There were 62 subjects in the intervention group (CHO-P), which received preoperative whey protein-infused CHO loading and POEOF; and 56 subjects formed the control group (CO), which was given usual care. The mean age was 49.5 ± 12.2 years (CHO-P) and 51.2 ± 11.9 years (CO). The trial found significant positive results which included shorter LPOHS (78.13 ± 33.05 vs. 99.49 ± 22.54 h); a lower readmission rate within one month PO (6% vs. 16%); lower weight loss (−0.3 ± 2.3 kg vs. −2.1 ± 2.3 kg); a lower C-reactive protein–albumin ratio (0.3 ± 1.2 vs. 1.1 ± 2.6); preserved muscle mass (0.4 ± 1.7 kg vs. −0.7 ± 2.6 kg); and better handgrip strength (0.6 ± 4.3 kg vs. −1.9 ± 4.7 kg) among CHO-P as compared with CO. However, there was no significant difference in mid-upper arm circumference and serum albumin level upon discharge. ERAS with preoperative whey protein-infused CHO loading and POEOF assured better PO outcomes.

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Section: Sample Size Calculationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of Enhanced Recovery after Surgery with Preoperative Whey Protein-Infused Carbohydrate Loading and Postoperative Early Oral Feeding among Surgical Gynecologic Cancer Patients: An Open-Labelled Randomized Controlled Trial

Ibrahim

Zaid

et al. 2020

Nutrients

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“…Sample size of study is calculated by using formula which was proposed by Woodword 25 . According to result of previous study by Balayla et al 20 , study needs about 33 subjects per group. After adjustment with 80% respond rate and 90% expected eligible rate (power = 80%, alpha level = 0.05), study plans to recruit a total of 110 subjects (55 subjects each group) to account for 20% dropped-out rate.…”

Section: Sample Size Calculationmentioning

confidence: 99%

“…This is because of utilisation of energy which converted from protein source of body (muscle) which promote catabolism. Thus, patients experienced weight loss and muscle mass loss postoperatively 20 .…”

mentioning

confidence: 99%

Fast Track Recovery Surgery with A Whey Protein Infused Carbohydrate Loading Drink Pre-Operatively and Early Oral Feeding Post-Operatively among Surgical Gynaecologic Cancer Patients: Study Protocol of an Open Labelled Randomised Controlled Trial

Ibrahim

et al. 2020

Preprint

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Introduction: There has been growing evidence on the favourable outcomes of fast tract recovery (FTR) surgery; expedite recovery, minimise complications, reduce length of hospital stay on surgical patients. However, there is lack of evidence on the effectiveness of FTR in surgical gynaecologic cancer patients. Most of previous study did not focus on feeding composition in FTR surgery protocol. This study aims to determine the effectiveness of FTR feeding with whey protein infused carbohydrate loading drink pre-operatively and early oral feeding post-operatively on post-operative outcomes among surgical gynaecologic cancer patients. Methods and analysis: This open labelled RCT will randomly allocate patients into intervention and control group. Ambulated Malaysian aged over 18 years and scheduled for elective surgery for (suspected) GC, will be included in this study. Intervention group will be given whey protein infused carbohydrate loading drinks evening before operation and 3 hours before operation as well as started on early oral feeding 4 hours post-operatively. Control group will be fasted overnight pre-operation and only allowed plain water, and the diet transition fashion is followed when there is bowel sound post-operatively. Primary outcomes of study are length of post-operative hospital stay, length of clear fluid toleration, solid food toleration and bowel function. Additional outcome measures are changes in nutritional status, biochemical profile and functional status. Data will be analysed on an intention-to-treat basis. Trial Registration Number: ClinicalTrials.gov, NCT03667755. Registered 12 September 2018 – Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03667755Protocol Version: Version 3 dated 27th September 2017

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Early versus delayed oral feeding after major gynaecologic surgery

Charoenkwan,

Nantasupha,

Muangmool

et al. 2024

Cochrane Database of Systematic Reviews

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Early Versus Delayed Postoperative Feeding After Major Gynaecological Surgery and its Effects on Clinical Outcomes, Patient Satisfaction, and Length of Stay: A Randomized Controlled Trial

Cited by 18 publications

References 24 publications

Impact of Enhanced Recovery after Surgery with Preoperative Whey Protein-Infused Carbohydrate Loading and Postoperative Early Oral Feeding among Surgical Gynecologic Cancer Patients: An Open-Labelled Randomized Controlled Trial

Impact of Enhanced Recovery after Surgery with Preoperative Whey Protein-Infused Carbohydrate Loading and Postoperative Early Oral Feeding among Surgical Gynecologic Cancer Patients: An Open-Labelled Randomized Controlled Trial

Fast Track Recovery Surgery with A Whey Protein Infused Carbohydrate Loading Drink Pre-Operatively and Early Oral Feeding Post-Operatively among Surgical Gynaecologic Cancer Patients: Study Protocol of an Open Labelled Randomised Controlled Trial

Early versus delayed oral feeding after major gynaecologic surgery

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