Early Versus Late Brain Magnetic Resonance Imaging after Neonatal Hypoxic Ischemic Encephalopathy Treated with Therapeutic Hypothermia

O'Kane, A; Vézina, Gilbert; Chang, Taeun; Bendush, Nicole; Ridoré, Michelande; Gai, Jiaxiang; Bost, James E.; Glass, Penny; Massaro, An N.

doi:10.1016/j.jpeds.2021.01.050

Cited by 20 publications

(14 citation statements)

References 30 publications

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“…In a recent paper, O'Kane and colleagues demonstrated a substantial correlation between early (<7 days) and late (≥7 days of age) MRI. However, early MRI was more consistently predictive of abnormal outcomes and more likely to identify severe injury in cases of discrepancy compared with late MRI [91].…”

Section: Optimal Timing Of Mrimentioning

confidence: 85%

“…Early MRI (i.e., approximately 4-5 days after birth) may however be preferable over late scanning (>7 days after birth) as DWI abnormalities can be assessed before pseudo-normalization has occurred, and MRI can be performed between completion of TH and transfer to another center. Previous studies that compared early to late MRI have demonstrated good agreement between these scans [89][90][91]. Moreover, diffusion and 1 H-MRS abnormalities have been reported to normalize from 4 to 5 days onwards following the insult and could therefore be missed when MRI is performed in the second week after birth [88].…”

Section: Optimal Timing Of Mrimentioning

confidence: 94%

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Magnetic Resonance Imaging in (Near-)Term Infants with Hypoxic-Ischemic Encephalopathy

2022

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Hypoxic-ischemic encephalopathy (HIE) is a major cause of neurological sequelae in (near-)term newborns. Despite the use of therapeutic hypothermia, a significant number of newborns still experience impaired neurodevelopment. Neuroimaging is the standard of care in infants with HIE to determine the timing and nature of the injury, guide further treatment decisions, and predict neurodevelopmental outcomes. Cranial ultrasonography is a helpful noninvasive tool to assess the brain before initiation of hypothermia to look for abnormalities suggestive of HIE mimics or antenatal onset of injury. Magnetic resonance imaging (MRI) which includes diffusion-weighted imaging has, however, become the gold standard to assess brain injury in infants with HIE, and has an excellent prognostic utility. Magnetic resonance spectroscopy provides complementary metabolic information and has also been shown to be a reliable prognostic biomarker. Advanced imaging modalities, including diffusion tensor imaging and arterial spin labeling, are increasingly being used to gain further information about the etiology and prognosis of brain injury. Over the past decades, tremendous progress has been made in the field of neonatal neuroimaging. In this review, the main brain injury patterns of infants with HIE, the application of conventional and advanced MRI techniques in these newborns, and HIE mimics, will be described.

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Section: Optimal Timing Of Mrimentioning

confidence: 85%

Section: Optimal Timing Of Mrimentioning

confidence: 94%

Magnetic Resonance Imaging in (Near-)Term Infants with Hypoxic-Ischemic Encephalopathy

2022

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“…Late MRI has been shown to be a good predictor of outcome (18)(19) and a previous study found no difference between early and late MRI scans in predicting outcome (29). However, a meta-analysis by Ouwehand et al (2020) found MRI injury scoring methods were more predictive during the first week than the second week of life, and a recent study showed better predictive ability of Barkovich and NICHD NRN scores when MRI was performed early (≤7 days) compared with late (>7 days) (48). Moreover, pseudonormalization of DWI can occur after the first week of life, restricting the value of the Weeke score to the first week (49)(50).…”

Section: J O U R N a L P R E -P R O O F 21mentioning

confidence: 96%

Relationship Between MRI Scoring Systems and Neurodevelopmental Outcome at Two Years in Infants With Neonatal Encephalopathy

Bhroin

Kelly

Sweetman

et al. 2022

Pediatric Neurology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…According to statistics, about a quarter of NHIE cases will die during the neonatal period, and another quarter may develop long-term sequelae such as cerebral palsy, epilepsy, and sensory disturbance, which seriously compromise the healthy growth of children's body and mind [ 4 ]. Choosing appropriate and effective treatment methods is crucial to improve the prognosis of NHIE children, and the postnatal care of neonates with hypoxic-ischemic encephalopathy (HIE) is also critical [ 5 , 6 ]. Accordingly, we herein discuss the application effect of nursing intervention for NHIE, aiming at providing clinical reference for improving the neurological and physical development of HIE children, which is of positive significance for improving the prognosis of such neonates.…”

Section: Introductionmentioning

confidence: 99%

Application Effect Analysis of Clinical Nursing Pathway in the Care of Neonatal Hypoxic-Ischemic Encephalopathy

Zhang

Wang

2022

Computational and Mathematical Methods in Medicine

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This research focuses on the effectiveness of the clinical nursing pathway (CNP) in the treatment of infant hypoxic-ischemic encephalopathy (NHIE). This research enrolled 120 cases of NHIE admitted to the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, including 70 cases (research group, the Res) who received CNP intervention and 50 cases (control group, the Con) treated by routine nursing pathway intervention. The psychomotor development index (PDI), mental development index (MDI), neurodevelopment (ND), physique growth, and incidence of adverse events (AEs) were recorded and analyzed. The results identified that in comparison with the Con (1) the PDI and MDI were obviously better in the Res 6 months postintervention; (2) the Res had significantly superior ND of behavioral capacity, passive tone, active tone, primitive reflex, and general assessment 1 month after intervention, as well as physical development of body weight, height, and head circumference after 40 days of birth, (3) the incidence of total AEs within 40 days was statistically lower in the Res. As a result, CNP is considerably superior to the traditional nursing pathway in the treatment of NHIE, and it merits clinical promotion.

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Early Versus Late Brain Magnetic Resonance Imaging after Neonatal Hypoxic Ischemic Encephalopathy Treated with Therapeutic Hypothermia

Cited by 20 publications

References 30 publications

Magnetic Resonance Imaging in (Near-)Term Infants with Hypoxic-Ischemic Encephalopathy

Magnetic Resonance Imaging in (Near-)Term Infants with Hypoxic-Ischemic Encephalopathy

Relationship Between MRI Scoring Systems and Neurodevelopmental Outcome at Two Years in Infants With Neonatal Encephalopathy

Application Effect Analysis of Clinical Nursing Pathway in the Care of Neonatal Hypoxic-Ischemic Encephalopathy

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