Early Waning of Maternal Measles Antibodies in Infants in Zhejiang Province, China: A Comparison of Two Cross-Sectional Serosurveys

Chong, Ka Chun; Yan, Rui; Liu, Yan; Zhou, Tianyuan; Jia, Katherine Min; Wang, Maggie Haitian; He, Hanqing

doi:10.3390/ijerph16234680

Cited by 9 publications

(10 citation statements)

References 27 publications

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“…Therefore, the role of rotavirus vaccines is also important. Moreover, increased risk of disease in younger children might be due to naive immune system in children of younger ages and waning of maternal antibodies [16][17][18][19][20][21]. The finding of this study is also in line with studies done in Benishangul region, Eastern Ethiopia, Enderta Woreda, Wolitta Soddo and southern Ethiopia [4,7,[22][23][24][25].…”

Section: Discussionsupporting

confidence: 87%

“…The effect of number of under-five children in the household on childhood diarrhoea varies by current age of mothers. Number of under-five children affects the occurrence of diarrhoea differently in older age mothers (35-49) versus younger age mothers (15)(16)(17)(18)(19)(20)(21)(22)(23)(24). The odds of the occurrence of diarrhoea for three or more number of under-five children (relative to two or less number of under-five children) in older age mothers was 4.7 times as high as in younger age mothers.…”

Section: Discussionmentioning

confidence: 99%

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Socio-demographic, environmental and behavioural risk factors of diarrhoea among under-five children in rural Ethiopia: further analysis of the 2016 Ethiopian demographic and health survey

Ferede

2020

BMC Pediatr

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Background: Diarrhoea is one of the major contributors to death among under-five children in Ethiopia. Studies conducted in different countries showed that rural children are more severely affected by diarrhoea than urban children. Thus, this study was aimed to identify the socio-demographic, environmental and behavioural associated risk factors of the occurrence of diarrhoea among under-five children in rural Ethiopia. Methods: Data for the study was drawn from the 2016 Ethiopian Demographic and Health Survey. A total of 8041 under-five children were included in the study. Binary logistic regression was used to assess the association of occurrence of diarrhoea with socio-demographic, environmental and behavioural factors among under-five children. Results: Children aged 6-11 months (AOR:3.5; 95% CI: 2.58-4.87), 12-23 months (AOR: 3.1; 95% CI: 2.33-4.04) and 24-35 months (AOR: 1.7; 95% CI: 1.26-2.34) as compared to > 35 months were significantly associated with an increasing prevalence of diarrhoea. Children in Afar region (AOR: 1.92; 95% CI: 1.01-3.64) and Gambela region (AOR: 2.12; 95% CI: 1.18, 3.81) were significantly associated with an increasing prevalence of diarrhoea, but a decreasing prevalence in Somali region (AOR: .42; 95% CI: (.217-.80) as compared to Tigray region. Increasing prevalence of diarrhoea was also significantly associated with male children (AOR: 1.3; 95% CI: 1.05-1.58); households who shared toilet facilities with other households (AOR: 1.4; 95% CI: 1.09-1.77); fourth birth order (AOR: 1.81; 95% CI: 1.17-2.79), and fifth and above birth order (AOR: 1.85; 95% CI: 1.22, 2.81) as compared to first order; and mother's current age 35-49 years in a household with ≥3 under-five children (AOR: 4.7; 95% CI: 1.64-13.45) as compared to those maternal ages of 15-24 years in a household with ≤2 under-five children. Conclusion: The age of a child, sex of a child, region, birth order, toilet facilities shared with other households and the interaction effect of the number of under-five children with mother's current age are identified as associated risk factors for diarrhoea occurrence among under-five children in rural Ethiopia. The findings show the need for planning and implementing appropriate prevention strategies considering these risk factors for rural under-five children.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Socio-demographic, environmental and behavioural risk factors of diarrhoea among under-five children in rural Ethiopia: further analysis of the 2016 Ethiopian demographic and health survey

Ferede

2020

BMC Pediatr

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“…A systematic literature review revealed that slower waning of maternal antibody in infants occurred in high disease burden settings than in sustained elimination settings and low burden settings. 22 Similarly to sustain elimination settings like Ontario, Canada 18 and Belgium, 19 a significant loss of measles protection by 3 months of age was observed in the non-elimination settings of Zhejiang, 23 Wuxi, 20 Tianjin, 11 Shufu (our study), China. Over decades, China has made great efforts to eliminate measles.…”

Section: Discussionsupporting

confidence: 57%

Waning of maternal antibody against measles virus in Shufu, China

Fan

Xue³

et al. 2022

Human Vaccines & Immunotherapeutics

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Background: As measles vaccination coverage has increased, measles infection has shifted to the population of infants. We conducted a follow-up seroepidemiological study among mothers and their infants to evaluate measles seroprevalence and the persistence of maternal measles antibody in Shufu, Kashgar from 2018 to 2020. Methods: Maternal venous blood and cord blood was obtained among mothers and their infants at 0, 3, 5, 8, 9, and 12 months of age. An enzyme-linked immunosorbent assay was used for quantitative measurement of measles antibodies. We analyzed the correlation between maternal and neonatal measles antibodies, and antibodies persistence after infants were born. Results: The overall neonatal maternal ratio was 2.38 (95%CI: 2.05–2.71). The measles antibodies for mothers and newborns were 438.93 IU/mL (95%CI: 409.47–470.51 IU/mL) and 440.10 IU/mL (95%CI: 410.82–471.48 IU/mL), respectively. Neonatal measles antibodies were dropping after birth and then beginning to increase starting at 8 months of age. Conclusions: Infant measles antibody levels progressively declined after birth regardless of maternal measles antibody levels. Efforts should be carried out to eliminate measles.

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Section: Discussionmentioning

confidence: 99%

Socio-demographic, environmental and behavioural risk factors of diarrhoea among under-five children in rural Ethiopia: further analysis of the 2016 Ethiopian demographic and health survey

Ferede¹

2020

Preprint

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Background: Diarrhoea is one of the major contributors to death among under-five children in Ethiopia. Studies conducted in different countries showed that rural children are more severely affected by diarrhoea than urban children. Thus, this study was aimed to identify the socio-demographic, environmental and behavioural associated risk factors of the occurrence of diarrhoea among under-five children in rural Ethiopia. Methods: Data for the study was drawn from the 2016 Ethiopian Demographic and Health Survey. A total of 8,041 under-five children were included in the study. Binary logistic regression was used to assess the association of occurrence of diarrhoea with socio-demographic, environmental and behavioural factors among under-five children. Results: Children aged 6-11 months (AOR: 3.5; 95% CI: 2.58-4.87), 12-23 months (AOR: 3.1; 95% CI: 2.33-4.04) and 24-35 months (AOR: 1.7; 95% CI: 1.26-2.34) as compared to >35 months were significantly associated with an increasing prevalence of diarrhoea. Children in Afar region (AOR: 1.92; 95% CI: 1.01-3.64) and Gambela region (AOR: 2.12; 95% CI: 1.18, 3.81) were significantly associated with an increasing prevalence of diarrhoea, but a decreasing prevalence in Somali region (AOR: .42; 95% CI: (.217-.80) as compared to Tigray region. Increasing prevalence of diarrhoea was also significantly associated with male children (AOR: 1.3; 95% CI: 1.05-1.58); households who shared toilet facilities with other households (AOR: 1.4; 95% CI: 1.09-1.77); fourth birth order (AOR: 1.81; 95% CI: 1.17-2.79), and fifth and above birth order (AOR: 1.85; 95% CI: 1.22, 2.81) as compared to first order; and mother’s current age 35-49 years in a household with ≥3 under-five children (AOR: 4.7; 95% CI: 1.64-13.45) as compared to those maternal ages of 15-24 years in a household with ≤2 under-five children.Conclusion: The age of a child, sex of a child, region, birth order, toilet facilities shared with other households and the interaction effect of the number of under-five children with mother’s current age are identified as associated risk factors for diarrhoea occurrence among under-five children in rural Ethiopia. The findings show the need for planning and implementing appropriate prevention strategies considering these risk factors for rural under-five children.

show abstract

Early Waning of Maternal Measles Antibodies in Infants in Zhejiang Province, China: A Comparison of Two Cross-Sectional Serosurveys

Cited by 9 publications

References 27 publications

Socio-demographic, environmental and behavioural risk factors of diarrhoea among under-five children in rural Ethiopia: further analysis of the 2016 Ethiopian demographic and health survey

Socio-demographic, environmental and behavioural risk factors of diarrhoea among under-five children in rural Ethiopia: further analysis of the 2016 Ethiopian demographic and health survey

Waning of maternal antibody against measles virus in Shufu, China

Socio-demographic, environmental and behavioural risk factors of diarrhoea among under-five children in rural Ethiopia: further analysis of the 2016 Ethiopian demographic and health survey

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