Early weight gain trajectories and body composition in infancy in infants born very preterm

Beunders, Victoria A A; Roelants, Jorine; Hulst, Jessie M.; Rizopoulos, Dimitris; Hokken-Koelega, Anita C S; Neelis, Esther; Fluiter, Kirsten S. de; Jaddoe, Vincent W V; Joosten, Koen; Vermeulen, Marijn J.

doi:10.1111/ijpo.12752

Cited by 8 publications

(5 citation statements)

References 49 publications

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“…Indeed, it has been nicely documented how in preterm infants born <30 weeks gestational age weight gain during NICU stay is weakly associated with higher absolute lean mass in infancy. However, such association does not persist after correction for length ( 40 ).…”

Section: Discussionmentioning

confidence: 97%

In-hospital growth and long-term neurodevelopmental outcomes of very low birth weight infants

Consales,

Porro,

Gangi

et al. 2023

Front. Pediatr.

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Background and ObjectivesVery low birth weight infants (VLBW) are at risk for adverse growth and neurodevelopmental outcomes. We aimed to evaluate the association between growth during Neonatal Intensive Care Unit (NICU) stay and long-term neurodevelopmental outcomes in a cohort of preterm VLBW newborns.MethodsWe conducted a longitudinal observational study in the Follow-up Service of our Clinic from January 2014 to April 2017. All preterm VLBW infants born at our hospital and enrolled in our follow-up program were considered eligible for the study. The neurodevelopmental assessment was performed using the Griffiths Mental Development Scales at 12 and 24 months corrected age.ResultsStudy population included 172 subjects (47.1% males) with a mean gestational age of 29 weeks and a mean birth weight of 1,117 g. A unitarian Δz-score increase in head circumference from birth to discharge was associated with a 1.6-point increase in General Quotient at 24 months corrected age. An association with subscales C and D was also found. Likewise, an increase in length Δz-score was associated with better 24-month subscale C scores although not reaching statistical significance. No relationship with the outcome at 24 months was found for weight gain.ConclusionsGrowth during NICU stay appears to be related to a more favorable neurodevelopmental outcome at 24 months corrected age, especially in the hearing and language domain (subscale C). The longitudinal evaluation of auxological parameters during hospitalization can contribute to the identification of subjects at risk for adverse neurodevelopmental outcomes in the first years of life.

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Section: Discussionmentioning

confidence: 97%

In-hospital growth and long-term neurodevelopmental outcomes of very low birth weight infants

Consales,

Porro,

Gangi

et al. 2023

Front. Pediatr.

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“…The use of weight at birth versus nadir weight is currently controversial. Weight nadir z-score may better reflect expected physiologic weight loss [ 39 ]. A study examining weight gain velocity calculations recommended the utilization of the weight nadir or day seven weight rather than birth weight [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Contemporary definitions of infant growth failure and neurodevelopmental and behavioral outcomes in extremely premature infants at two years of age

Strobel,

Wood,

Valentine

et al. 2024

J Perinatol

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Background Associations of 2-year neurodevelopmental and behavioral outcomes with growth trajectories of preterm infants are unknown. Methods This secondary analysis of a preterm cohort examined in-hospital and discharge to 2-year changes in anthropometric z-scores. Two-year follow-up included Bayley Scales of Infant Development (BSID-III) and Child Behavior Checklist. Results Among 590 infants, adjusted in-hospital growth was not associated with any BSID-III subscale. Occipitofrontal circumference (OFC) growth failure (GF) in-hospital was associated with increased adjusted odds of attention problems (aOR 1.65 [1.03, 2.65]), aggressive behavior (aOR 2.34 [1.12, 4.89]), and attention-deficit-hyperactivity symptoms (aOR 1.86 [1.05, 3.30]). Infants with OFC GF at 2 years had lower adjusted BSID-III language scores (−4.0 [−8.0, −0.1]), increased odds of attention problems (aOR 2.29 [1.11, 4.74]), aggressive behavior (aOR 3.09 [1.00, 9.56]), and externalizing problems (aOR 3.01 [1.07, 8.45]) compared to normal OFC growth cohort. Conclusion Infants with OFC GF are at risk for neurodevelopmental and behavioral impairment. Clinical trial registration This study is a secondary analysis of pre-existing data from the PENUT Trial Registration: NCT01378273.

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“…The use of weight at birth versus nadir weight is currently controversial. Weight nadir z-score may better reflect expected physiologic weight loss ( 32 ). A study examining weight gain velocity calculations recommended the utilization of the weight nadir or day seven weight rather than birth weight ( 33 ).…”

Section: Discussionmentioning

confidence: 99%

Contemporary Definitions of Infant Growth Failure and Neurodevelopmental and Behavioral Outcomes in Extremely Premature Infants at Two Years of Age

Strobel

Wood

Valentine

et al. 2023

Preprint

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Introduction: The association of 2-year neurodevelopmental and behavioral outcomes with in-hospital or post-discharge growth failure (GF) using contemporary definitions for preterm infants is unknown. Methods In a secondary analysis of a preterm cohort, changes in anthropometric z-scores were examined between birth and hospital discharge, and from discharge to 2 years. The 2-year evaluation included Bayley Scales of Infant Development (BSID-III) and Child Behavior Checklist (CBCL). Results Among 629 infants, accelerated linear growth from birth to discharge was associated with higher BSID-III cognitive scores (+ 3.2 points [IQR 0.02, 6.4]) while in-hospital GF was not associated with any outcomes. Infants with weight GF after discharge had lower BSID-III motor scores (-3.1 points [-5.9, -0.2]). Infants with accelerated weight growth after discharge had increased odds of behavioral problems on the CBCL (aOR 1.9 [1.03, 3.5]). Discussion In-hospital and post-hospitalization growth metrics are modestly associated with neurodevelopmental outcomes with length gains apparently most beneficial.

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Early weight gain trajectories and body composition in infancy in infants born very preterm

Cited by 8 publications

References 49 publications

In-hospital growth and long-term neurodevelopmental outcomes of very low birth weight infants

In-hospital growth and long-term neurodevelopmental outcomes of very low birth weight infants

Contemporary definitions of infant growth failure and neurodevelopmental and behavioral outcomes in extremely premature infants at two years of age

Contemporary Definitions of Infant Growth Failure and Neurodevelopmental and Behavioral Outcomes in Extremely Premature Infants at Two Years of Age

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