Early weight loss after laparoscopic sleeve gastrectomy predicts midterm weight loss in morbidly obese Asians

Chew, C. K.; Tan, Ian Jse-Wei; Ng, H. J.; Lomanto, Davide; So, Jimmy Bok Yan; Shabbir, Asim

doi:10.1016/j.soard.2017.05.016

Cited by 25 publications

(13 citation statements)

References 26 publications

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“…We have observed 24,8 ± 14% of excess weight loss (EWL) at 30 days following LSG. Our results are in agreement with recent studies that reported 23,9 ± 9.6% [ 23 ] and 22 ± 2,21% [ 24 ] EWL at one month after LSG. There was a 5,2 ± 2,55 kg/m 2 decrease in the BMI of LSG patients at 30 days following surgery (Table 1 ).…”

Section: Discussionsupporting

confidence: 94%

Early postoperative changes of sphingomyelins and ceramides after laparoscopic sleeve gastrectomy

et al. 2018

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BackgroundThis study aimed to determine early postoperative changes of serum sphingomyelin (SM) and ceramide (CER) species following laparoscopic sleeve gastrectomy (LSG).MethodsTwenty obese patients [mean body mass index (BMI) 45,64 ± 6,10 kg/m2] underwent LSG and normal weight control patients (mean BMI 31,51 ± 6,21 kg/m2) underwent laparoscopic cholecystectomy. Fasting blood samples were collected prior to surgery, at day 1 and day 30 after surgery. Circulating levels of C16-C24 SMs, C16-C24 CERs and sphingosine-1-phosphate (S1P) were determined by an optimized multiple reaction monitoring (MRM) method using ultra fast-liquid chromatography (UFLC) coupled with tandem mass spectrometry (MS/MS). Serum activity of neutral sphingomyelinase (N-SMase) was assayed by standard kit methods, and ceramide-1-phosphate (C1P) levels were determined by enzyme-linked immunosorbent assay (ELISA). Lipid profile, routine biochemical and hormone parameters were assayed by standard kit methods. Insulin sensitivity was evaluated using homeostatic model assessment for insulin resistance (HOMA IR).ResultsA significant decrease was observed in serum levels of very-long-chain C24 SM, very-long-chain C22-C24 CERs, HOMA-IR, N-SMase and C1P in LSG patients after postoperation day 1 and day 30 compared to preoperation levels. At 30 days postsurgery, BMI was reduced by 11%, fasting triglycerides were significantly decreased, and insulin sensitivity was increased compared to presurgery values. A significant positive correlation was found between HOMA-IR and serum levels of C22-C24 CERs in LSG patients.ConclusionWe conclude that very long chain CERs may mediate improved insulin sensitivity after LSG.

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Section: Discussionsupporting

confidence: 94%

Early postoperative changes of sphingomyelins and ceramides after laparoscopic sleeve gastrectomy

et al. 2018

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“…In the literature, the target for adequate weight loss after LSG has been reported as 50% EBWL within 6-months 13 , 50% EBWL within 1-year 5 , 55% EBWL within 1-year 9 , 50% EBWL within 2-years 14 , 15 , and even 50% EBWL within 3-years 10 . Our results used a relatively shorter follow-up period in comparison.…”

Section: Discussionmentioning

confidence: 99%

“…Early postoperative weight loss is reported to be an important predictive factor for overall weight loss 1- and 3-years after bariatric surgery non-Asian 5 , 8 , 9 and Asian populations 10 . Kanerva et al 11 demonstrated that in the short-term, considered to be 6-months after bariatric surgery, changing dietary macronutrient composition affects 10-year postoperative weight.…”

Section: Introductionmentioning

confidence: 99%

Check point to get adequate weight loss within 6-months after laparoscopic sleeve gastrectomy for morbid obesity in Asian population

Chen

Lee

et al. 2020

Sci Rep

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Purpose of this study is to develope a scoring system to predict the likelihood of excess body weight loss (EBWL) ≥ 50% 6-months after laparoscopic sleeve gastrectomy (LSG). From April 2016 to September 2018, data was collected from 160 patients (BMI ≥ 32) who underwent primary LSG with at least 6-months follow-up. They were separated into score generation (operated by one surgeon, n = 122) and validation groups (operated by 3 different surgeons, n = 38). EBWL at 6-months ≥ 50% was considered adequate weight loss. Independent variables including age, gender, initial body mass index (BMI), comorbidities, life-style habits, percentage of EBWL and percentage of total body weight loss at 1-week, 1-month, and 3-months were analyzed with mutivariate logistic regression to generate the scoring system. The system was applied to internal and external validation groups to determine efficacy. As results, between the score generation and internal validation groups, the only significant difference in patient characteristics was in exercise participation. EBWL at 1-month > 19.5% (1 point) and EBWL at 3-months > 37.7% (2 points) were identified as independent factors to predict EBWL at 6-months ≥ 50%. When scores were > 1, the system had 94.03% positive predictive value (PPV) and 81.82% negative predictive value (NPV) (AUC: 0.923). Internal validation scores > 1 had a 95.83% PPV and 85.71% NPV (AUC: 0.975). External validation results showed 88.59% PPV and 72.00% NPV (AUC: 0.802). We concluded that this scoring system provides a reliable, objective prediction of EBWL at 6-months ≥ 50%. Patients requiring more aggressive clinical follow-up and intervention can be detected as early as 1- to 3-months after LSG.

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“…%EWL or the percentage of total weight loss at 1–6 months could be used as an early weight loss indicator. 17 , 40 , 41 The prediction model was more time-efficient when %EWL at 3 months was used to predict the long-term weight loss outcome. %EWL at 3 months was not a significant independent variable in the logistic regression analysis of risk factors for weight loss failure.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Weight Loss Outcome of Laparoscopic Sleeve Gastrectomy Predicted by the Percentage of Excess Weight Loss at 6 Months in Chinese Patients with Body Mass Index ≥ 32.5 Kg/m2

Wang¹,

Tian²,

Xu³

et al. 2022

DMSO

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Purpose To evaluate the predictive effect of the initial weight loss on the long-term weight loss in Chinese patients with a body mass index (BMI) ≥ 32.5 kg/m 2 who underwent LSG. Patients and Methods The follow-up was completed via phone or WeChat for outpatients and at the hospital for inpatients. We evaluated the BMI, percentage of excess weight loss (%EWL), and type 2 diabetes mellitus, hypertension, and hyperlipidemia statuses. Linear and logistic regression analyses were performed on the relationship between the initial and long-term weight loss. The optimal cut-off value was determined by receiver operating characteristic (ROC) curve analysis. Results We enrolled 307 patients, with a median preoperative BMI of 39.68 (35.68, 45.47) kg/m 2 . %EWL ≥ 50% was regarded as successful weight loss, and 76.55% of the patients lost their weight successfully. (Reviewer #1, comment #4) %EWL at 6 months and 5 years were positively correlated ( P < 0.001). Further, the following linear equation could express the relationship: (%EWL 5 years = 29.193 + 0.526 × %EWL 6 months ). %EWL ≥ 58.57% at 6 months was the best predictor of successful weight loss at 5 years after LSG (Reviewer #1, comment #5) (sensitivity, 73.62%; specificity, 73.61%; AUC value, 0.780). Internal verification of the prediction model revealed satisfactory results in terms of discrimination and calibration. Conclusion In Chinese patients with BMI ≥ 32.5 kg/m 2 who underwent LSG, %EWL at 6 months and 5 years were correlated. %EWL ≥ 58.57% at 6 months was a predictor of successful long-term weight loss.

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Early weight loss after laparoscopic sleeve gastrectomy predicts midterm weight loss in morbidly obese Asians

Cited by 25 publications

References 26 publications

Early postoperative changes of sphingomyelins and ceramides after laparoscopic sleeve gastrectomy

Early postoperative changes of sphingomyelins and ceramides after laparoscopic sleeve gastrectomy

Check point to get adequate weight loss within 6-months after laparoscopic sleeve gastrectomy for morbid obesity in Asian population

Long-Term Weight Loss Outcome of Laparoscopic Sleeve Gastrectomy Predicted by the Percentage of Excess Weight Loss at 6 Months in Chinese Patients with Body Mass Index ≥ 32.5 Kg/m2

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