To improve the transport infrastructure of the Republic of Uzbekistan, the monolithic structure of bridges and overpasses began to be used. The article presents the calculation of a monolithic overpass on the 1083rd km of the M-39 highway passing through Samarkand. The results of the calculation of a monolithic overpass from dynamic load are presented based on the records of two real seismograms for two dangerous earthquakes for the system with spectral composition: Gazli (Uzbekistan) and Manjil (Iran). The calculations show that to ensure guaranteed seismic safety of transport structures, it is necessary to carry out design calculations based on sets of records of earthquakes that occurred, close in dominant frequencies to the characteristics of the construction site. Such a provision should be introduced into the relevant regulatory documents.