Earwax of patients with hidradenitis suppurativa: A retrospective study

Shibuya, Yasuyuki; Morioka, Daichi; Nomura, Misako; Zhang, Zhuo; Utsunomiya, Hidetsuna

doi:10.5999/aps.2019.00290

Cited by 5 publications

(5 citation statements)

References 16 publications

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“… 13 The reported positive effects of antiandrogen therapy may support the possibility that androgens play a negative role in HS.” 12 However, a new study about the role of gender in HS in a Korean population found the female-to-male ratio was 1:1.6. They described “a remarkable predisposition for HS among males” and noted that this finding was contrary to the findings usually reported in European studies, 14 but was in line with results shown in recent Japanese 15 and Turkish studies. 16 Two hypotheses based on genetic and environmental factors were developed to explain “Asian” vs “European” difference.…”

Section: Discussionsupporting

confidence: 61%

How to Define Mild to Severe Hidradenitis Suppurativa? A Simple New Tool Based on Latent Class Analysis of EPIVER Data Study

Perrot¹,

Maccari²,

Guillem³

et al. 2022

CCID

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Purpose Hidradenitis suppurativa (HS) is an inflammatory skin disease characterized by recurrent or chronic painful and suppurating lesions in the apocrine gland-bearing regions. The lack of knowledge about HS and its extremely heterogeneous clinical presentation, in terms of both lesion appearance and sites of involvement, frequently delay its diagnosis for several years. Objectives: in this study, using the latent class analysis, it was demonstrated that severity of HS could be evaluated not only with clinical or surgical characteristics but also with gender specificities. Patients and Methods Clinical and sociodemographic data of HS patients were retrospectively analysed with the latent class method in order to create a classification tool of disease severity. Results From the study of 1428 HS patients (544 men and 884 women), two classification models, depending on gender, were developed. Each classification model was composed of three distinct latent classes clearly identified and defined from mild-to-severe cases of HS. These classification models of HS severity were not distorted by patient ages and were coherent with Hurley stages but were more clinically precise. Conclusion In this study, a convenient classification tool, useful for facilitating decision support in routine practice, has been developed. This tool could be used to define clinical subgroups within a study population.

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Section: Discussionsupporting

confidence: 61%

How to Define Mild to Severe Hidradenitis Suppurativa? A Simple New Tool Based on Latent Class Analysis of EPIVER Data Study

Perrot¹,

Maccari²,

Guillem³

et al. 2022

CCID

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“…Regarding the association between the ABCC11 genotypes and apocrine glands, well‐developed apocrine glands have been observed in the EACs of patients carrying the wet earwax genotypes as opposed to the dry earwax genotype 7 , 8 . Furthermore, when compared with the general Japanese population, the proportion of patients with wet earwax is higher in those with hidradenitis suppurativa, which is an inflammatory skin disease in the apocrine gland–bearing skin 22 , 23 . It has been proposed that otitis externa with high epithelial turnover can contribute to acquired middle ear cholesteatoma 2 , 3 ; therefore, the maintenance of apocrine glands may be associated with this disease.…”

Section: Discussionmentioning

confidence: 99%

“…7,8 Furthermore, when compared with the general Japanese population, the proportion of patients with wet earwax is higher in those with hidradenitis suppurativa, which is an inflammatory skin disease in the apocrine gland-bearing skin. 22,23 It has been proposed that otitis externa with high epithelial turnover can contribute to acquired middle ear cholesteatoma 2,3 ; therefore, the maintenance of apocrine glands may be associated with this disease.…”

Section: Hypothesis Of the Mechanism Underlying The Association Between The Abcc11 Genotypes At Site 538 And Acquired Middle Ear Cholestementioning

confidence: 99%

Association Between Earwax‐Determinant Genotypes and Acquired Middle Ear Cholesteatoma in a Japanese Population

Hara

Kusunoki

Nakagawa

et al. 2021

Otolaryngol.--head neck surg.

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Objective A single-nucleotide polymorphism 538G>A in the human ABCC11 gene is a determinant of the earwax morphotype. ABCC11 538GG and GA correspond to wet earwax and 538AA to dry earwax. Despite a putative positive correlation between the frequency of the 538G allele and the prevalence of cholesteatoma, minimal clinical information is currently available. We aimed to evaluate this association between the ABCC11 genotypes and acquired middle ear cholesteatoma. Study Design Case-control study. Setting Single-center academic hospital. Methods We recruited 67 Japanese patients with acquired middle ear cholesteatoma (cholesteatoma group) and 100 Japanese controls with no history of middle ear cholesteatoma. We assessed the ABCC11 genotypes for all participants. Clinical information was collected from the cholesteatoma group. The genotype data of 104 Japanese people from the 1000 Genomes Project who represent the general population were used. Results The proportion of participants with ABCC11 538GG or GA was significantly higher in the cholesteatoma group than in the control group or general Japanese population ( P < .001). The ABCC11 538G allele frequency was also significantly higher in the cholesteatoma group than in the control group or general Japanese population ( P < .001). Multivariate logistic regression analyses revealed a significant association between the ABCC11 genotype and acquired middle ear cholesteatoma (odds ratio, 5.49; 95% CI, 2.61-11.5; P < .001). Conclusion Our results suggest that the ABCC11 genotypes could be associated with the development of acquired middle ear cholesteatoma among Japanese people.

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“…We included 10 studies (five retrospective case-series, four crosssectional, and one prospective observational cohort study) with a total of 30,125 HS patients. [15][16][17][18][19][20][21][22] Characteristics of included studies The characteristics of the included studies are summarized in…”

Section: Study Selectionmentioning

confidence: 99%

Hidradenitis suppurativa in East and Southeast Asian populations: a systematic review and meta‐analysis

2021

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Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that presents with recurrent inflammatory nodules and draining tunnels in the skin. Most HS studies have focused on Western populations, and the understanding of how HS characteristics differ in specific Asian ethnicities is poor. We conducted the first systematic review and metaanalysis to characterize HS patients from East and Southeast Asia. PubMed, Embase, and Ovid MEDLINE databases were searched from inception to June 12, 2020. Englishlanguage case-series, cross-sectional, observational, and randomized controlled trial studies investigating HS in East and Southeast Asian populations were screened by titles, abstracts, and articles in duplicate. Of 136 citations, 10 studies were included in the meta-analysis. Data on gender distribution, lesion distribution in the axilla and gluteal regions, and family history were extracted in duplicate. A random effects model was used for the meta-analysis. A total of 30,125 HS patients were included in the analysis. Most patients were male (66%, 95% CI = 60-72%). About half of Asian patients with HS develop lesions in the axilla (52%, 95% CI = 33-72%) and the buttocks (48%, 95% CI = 38-57%). Only a small subset had positive family history of HS (5%, 95% CI = 2-8%). We report an up-to-date characterization of HS in East and Southeast Asian populations and highlight differences in their Western counterparts. These results will hopefully improve understanding for how HS may manifest, lead to more personalized treatments for Asian patients with HS, and usher in a proper patient-centered approach to treating the disease.

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Earwax of patients with hidradenitis suppurativa: A retrospective study

Cited by 5 publications

References 16 publications

How to Define Mild to Severe Hidradenitis Suppurativa? A Simple New Tool Based on Latent Class Analysis of EPIVER Data Study

How to Define Mild to Severe Hidradenitis Suppurativa? A Simple New Tool Based on Latent Class Analysis of EPIVER Data Study

Association Between Earwax‐Determinant Genotypes and Acquired Middle Ear Cholesteatoma in a Japanese Population

Hidradenitis suppurativa in East and Southeast Asian populations: a systematic review and meta‐analysis

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