EASL Clinical Practice Guideline: Occupational liver diseases

Colombo, Massimo; Vecchia, Carlo La; Lotti, Marcello; Lucena, M.I.; Stove, Christophe; Paradis, Valérie; Newsome, Philip N.

doi:10.1016/j.jhep.2019.08.008

Cited by 27 publications

(18 citation statements)

References 131 publications

(144 reference statements)

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“…In the EASL Clinical Practice Guideline, acute liver injury is defined by the presence of any one of the following criteria: ALT ≥5× ULN, ALP ≥2× ULN (particularly if there is concomitantly elevated GGT in the absence of bone disease), and ALT ≥3× ULN and simultaneous TB >2× ULN. Besides that, liver injury can be classified as hepatocellular, cholestatic, and mixed pattern according to the R value ([ALT/ULN]/[ALP/ULN]) [2].…”

Section: Discussion/conclusionmentioning

confidence: 99%

“…It is known that occupational exposures can induce liver injury in a similar way to prescription drugs; herbal and dietary supplements and workplace exposure have been implicated in the full spectrum of liver disease. A variety of chemicals, including solvents, pesticides, and metals, have been linked to occupational liver diseases [2].…”

Section: Introductionmentioning

confidence: 99%

“…Workplace exposure has been associated with acute and chronic liver diseases. However, its prevalence is inadequately quantified, and their epidemiology is limited [2].…”

Section: Introductionmentioning

confidence: 99%

“…Occupational liver diseases may result from accidental exposure to a significative quantity of product, which is uncommon and easily recognized, or from prolonged lower-level exposures, which is more frequent but often overlooked. Normally, prolonged lower-level exposures have an insidious onset and may be asymptomatic or obfuscated and confounded by concurrent conditions [2].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A Case of Liver Injury after Exposure to Isopropanol: A Challenging Diagnosis

Santos

Nunes

Matos

et al. 2020

GE Port J Gastroenterol

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Drug-induced liver injury is hardly diagnosed, considering not only the wide range of hepatotoxic substances but also the diversity of associated phenotypes and the absence of specific biomarkers. Symptom chronology, drug or toxic exposure, and temporal association help to establish the diagnosis. Exposure to isopropanol has known but rare toxic effects. We report the clinical case of a 33-year-old female hairdresser admitted to the hospital with fatigue, epigastric pain, and jaundice. She presented the following values: aspartate aminotransferase, 485 U/L; alanine transaminase, 908 U/L; ALP, 240 U/L; GGT, 370 U/L; total bilirubin, 3.5 mg/dL; and direct bilirubin, 2.1 mg/dL. Albumin, platelet, and INR values were normal. Structural, infectious, immune, and vascular causes were excluded. Liver biopsy was suggestive of toxic hepatitis. A possible association with ibuprofen intake was considered. The patient resumed professional activity, with fatigue and jaundice relapse, as well as a new liver enzyme increase, despite ibuprofen withdrawal. It was concluded that a new hair product containing isopropanol had recently been introduced. As soon as its professional use was discontinued, there was no recurrence of the symptoms. Given the temporal association between the development of acute hepatitis and the use of an isopropanol-containing product, liver toxicity by exposure to isopropanol was assumed. This substance is metabolized in the liver and toxicity may occur by ingestion, skin exposure, or inhalation, and it is described in cases of occupational or accidental exposure. The treatment is symptomatic and comprises toxic suspension.

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Section: Discussion/conclusionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Workplace exposure has been associated with acute and chronic liver diseases. However, its prevalence is inadequately quantified, and their epidemiology is limited [2].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Case of Liver Injury after Exposure to Isopropanol: A Challenging Diagnosis

Santos

Nunes

Matos

et al. 2020

GE Port J Gastroenterol

View full text Add to dashboard Cite

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“…Another factor that can cause behavioral changes in rat is the presence of toxic hepatitis. According to (17)(18)(19)(20), toxic hepatitis arises from continuous exposure to toxic substances, causing inflammation of the liver. Toxic hepatitis in a severe condition can cause death.…”

Section: Fig 6 Average Weight Of Feed Consumed By Male Ratsmentioning

confidence: 99%

ACUTE TOXICITY TEST OF LOW CALCIUM OXALATE PORANG (Amorphophallus mueleri BLUME) FLOUR

Donowarti¹,

Widjanarko²,

Yunianta³

et al. 2021

Iraqi J. Agric. Sci.

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A field experiment Porang (Amorphophallus mueleri Blume) has the potential to be developed as a functional food ingredient because it contains high levels of glucomannan. Research on the acute toxicity test of macerated porang flour has been carried out. The results of research showed a toxic effect which was characterized by high SGOT and sodium levels. The purpose of this study was to find out the safety level of consuming porang flour with lowered calcium oxalate content. This research was an experimental study designed in one directional-pattern Completely Randomized Design using 5 treatments of porang flour administration with doses of 0; 5; 50; 500; 5000 and 15000 mg/kgbw and 6 repetitions for 60 days using Wistar-strain white rats (Rattus norvegicus) as laboratory animals. The results showed that during the treatment, the administration up to a dose of 500 mg/kgbw did not give a significant difference to all observed variables. The administration of 5000 and 15000 mg/kgbw gave a significant difference on the changes in body weight, the addition of the amount of water drunk, the levels of Calcium, Potassium and Sodium in the blood, SGOT and SGPT values, and observation on necrotic cells in the kidneys. The administration of the highest porang flour dosage, namely 15000 mg/kgbw did not cause any rat mortality and did not cause any real cell damage to the liver, but caused hyperactive behavior in female rats.

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Scavenging ROS to Alleviate Acute Liver Injury by ZnO‐NiO@COOH

Liu

Zhu

et al. 2022

Advanced Science

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Currently, the incidence of acute liver injury (ALI) is increasing year by year, and infection with coronavirus disease 2019 (COVID-19) can also induce ALI, but there are still no targeted therapeutic drugs. ZnO-NiO particles is mainly used to clean up reactive oxygen species (ROS) in industrial wastewater, and it is insoluble in water. Its excellent properties are discovered and improved by adding shuttle-based bonds to make it more water-soluble. ZnO-NiO@COOH particles are synthetically applied to treat ALI. The p-n junction in ZnO-NiO@COOH increases the surface area and active sites, thereby creating large numbers of oxygen vacancies, which can quickly adsorb ROS. The content in tissues and serum levels of L-glutathione (GSH) and the GSH/oxidized GSH ratio are measured to assess the capacity of ZnO-NiO@COOH particles to absorb ROS. The ZnO-NiO@COOH particles significantly reduce the expression levels of inflammatory factors (i.e., IL-1, IL-6, and TNF-𝜶), macrophage infiltration, and granulocyte activation. ZnO-NiO@COOH rapidly adsorb ROS in a short period of time to block the generation of inflammatory storms and gain time for the follow-up treatment of ALI, which has important clinical significance.

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EASL Clinical Practice Guideline: Occupational liver diseases

Cited by 27 publications

References 131 publications

A Case of Liver Injury after Exposure to Isopropanol: A Challenging Diagnosis

A Case of Liver Injury after Exposure to Isopropanol: A Challenging Diagnosis

ACUTE TOXICITY TEST OF LOW CALCIUM OXALATE PORANG (Amorphophallus mueleri BLUME) FLOUR

Scavenging ROS to Alleviate Acute Liver Injury by ZnO‐NiO@COOH

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