East asian herbal medicine for the treatment of children with attention deficit hyperactivity disorder: A Systematic Review and Meta-analysis

A National Survey on the Clinical Practice Patterns of Korean Medicine Doctors for Attention Deficit Hyperactivity Disorder (ADHD) in Children and Adolescents

“…In a meta-analysis of 746 children with ADHD [ 20 ], combined therapy involving East Asian herbal medicine (EAHM) alongside conventional WM exhibited a superior clinical efficacy rate when compared to conventional WM alone. The integration of EAHM significantly reduced the scores on all five subscales of the Conner’s Parent Rating Scales compared to methylphenidate alone.…”

“…Among the above drugs, four, except for Zizyphi Spinosae Semen, were included in the top 12 frequently used herbs in a literature review [ 51 ] that analyzed the prescriptions of 88 traditional Chinese medicines for ADHD treatment. In addition, Polygalae Radix, Acori Graminei Rhizoma, and Rehmanniae Radix Preparat were included in the top five most frequently used herbs in an SR study [ 20 ], which analyzed 42 RCTs of herbal medicine treatment for ADHD in children and adolescents. The top five frequently used acupoints in acupuncture were PC6, GV20, LI4, LR3, and HT7.…”

“…Various complementary and alternative medicines (CAMs) have been used to improve ADHD symptoms and reduce the risk of ADHD by minimizing the use of psychostimulants with interventions, such as behavioral therapy, parental counseling, herbal medicine, and acupuncture [ 18 , 19 ]. East Asian traditional medicine uses herbal medicine [ 20 , 21 , 22 ] and acupuncture [ 23 , 24 , 25 , 26 ] to treat ADHD. In comparison to other CAM therapies, acupuncture is regarded as an economical and simple-to-use treatment for ADHD [ 23 ].…”

“…In comparison to other CAM therapies, acupuncture is regarded as an economical and simple-to-use treatment for ADHD [ 23 ]. The use of acupuncture [ 23 , 27 ] or herbal treatment [ 20 ], in addition to conventional treatment, has demonstrated superior clinical efficacy in alleviating ADHD symptoms compared to that of conventional treatment alone. However, because standard treatment protocols and clinical practice guidelines for herbal medicine and acupuncture for ADHD have not been established, Korean medicine doctors (KMDs) find it difficult to use reliable evidence to optimize KM treatment.…”

Network analysis, in vivo, and in vitro experiments identified the mechanisms by which Piper longum L. [Piperaceae] alleviates cartilage destruction, joint inflammation, and arthritic pain

“…Natural substances offer various pharmacologically active constituents, which have a long history of human use for the treatment of various diseases ( Jo et al, 2023c ; Lee et al, 2023 ). The unique properties of natural products, such as multitarget effects based on multiple compounds, are thought to be well adapted to the requirements of DMOADs in drug discovery ( Yang et al, 2017 ; Luo et al, 2020 ; Jo et al, 2021 ; 2023b ; Panossian, 2023 ; Ren et al, 2023 ).…”