Easy access to the family of thiazole N-oxides using HOF·CH₃CN

Abstract

An efficient procedure for transferring an oxygen atom to thiazole-containing compounds, resulting in the corresponding N-oxides, was developed by using HOF x CH3CN; mild reaction conditions, high yields and easy purification are the main features of this novel route, while X-ray structural analysis reveals a hydrogen bond between the N-oxide functionality and a water molecule.

Heteroatom oxidation controls singlet–triplet energy splitting in singlet fission building blocks

“…N -Oxidations, on the other hand, also systematically improve Δ E ST , but at the expense of an attractive T 1 energy. While these specific units have not been described in the literature, previously reported preparation of S -oxidized 22 and S , S -(di)oxidized 22,23 analogs of benzothiadiazole, as well as N -oxidized thiazoles, 24 bithiazoles, 25 and thiadiazoles 26 suggest that they are synthesizable.…”

Halogens and noble gases

“…This has been demonstrated by the synthesis of a number of thiazole N-oxides using HOF Á MeCN. 17 One application of the more reactive halogens is in generating the highest known oxidation states of elements. A previous report that AuF 7 may be prepared by the reaction of AuF 5 with F 2 is not supported by calculations which clearly show that the reverse reaction is strongly exothermic with a low activation barrier.…”

Structural, IR spectra NBO, TDDFT, AIM calculation, biological activity and docking property of [1,2,4]-triazolo[3,4-b][1,3,4] thiadiazole

“…These are found in a number of various food products and flavors and are used in the manufacturing of prepackaged food products including noodles [7]. Thiazoles help flavorists to create healthier crops by enhancing the flavor of meats and savory foods without the accumulation of excess salts or fats [8]. 1,2,4-Triazole derivatives and their bonded heterocyclic correspondents are well known for their different biological activities and 1,2,4-triazole rings have been combined into ligands used in coordination compounds.…”