Easy and fast <i>in situ</i> functionalization of exfoliated 2D black phosphorus with gold nanoparticles

Moschetto, Salvatore; Ienco, Andrea; Manca, Gabriele; Serrano‐Ruiz, Manuel; Peruzzini, Maurizio; Mezzi, A.; Brucale, Marco; Bolognesi, Margherita; Toffanin, Stefano

doi:10.1039/d1dt02123k

Cited by 9 publications

(4 citation statements)

References 67 publications

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“…The three phonon modes (A 1 g , B 2g , and A 2 g ) of the BP-PEG@Au-GSH-DOX spectrum are redshifted due to the oscillation hindrance of phosphorus atoms by interacting with PEG and Au, thus reducing the corresponding Raman scattering energy. This observation further confirms the successful functionalization of BP to synthesize the BP-PEG@Au-GSH-DOX nanoconjugate [54][55][56].…”

Section: Morphology and Characterization Of Synthesized Nanomaterialssupporting

confidence: 73%

Nanoscale Evaluation of the Degradation Stability of Black Phosphorus Nanosheets Functionalized with PEG and Glutathione-Stabilized Doxorubicin Drug-Loaded Gold Nanoparticles in Real Functionalized System

Gunathilaka,

Shimomura

2024

Molecules

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Two-dimensional black phosphorus (2D BP) has attracted significant research interest in the field of biomedical applications due to its unique characteristics, including high biocompatibility, impressive drug-loading efficiency, phototherapeutic ability, and minimal side effects. However, its puckered honeycomb lattice structure with lone-pair electrons of BP leads to higher sensitivity and chemical reactivity towards H2O and O2 molecules, resulting in the degradation of the structure with physical and chemical changes. In our study, we synthesize polyethylene glycol (PEG) and glutathione-stabilized doxorubicin drug-assembled Au nanoparticle (Au-GSH-DOX)-functionalized BP nanosheets (BP-PEG@Au-GSH-DOX) with improved degradation stability, biocompatibility, and tumor-targeting ability. Transmission electron microscopy, X-ray photoelectron spectroscopy, and Raman spectroscopy indicate the nanoscale degradation behavior of synthesized nanoconjugates in three different environmental exposure conditions, and the results demonstrate the remarkable nanoscale stability of BP-PEG@Au-GSH-DOX against the degradation of BP, which provides significant interest in employing 2D BP-based nanotherapeutic agents for tumor-targeted cancer phototherapy.

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Section: Morphology and Characterization Of Synthesized Nanomaterialssupporting

confidence: 73%

Nanoscale Evaluation of the Degradation Stability of Black Phosphorus Nanosheets Functionalized with PEG and Glutathione-Stabilized Doxorubicin Drug-Loaded Gold Nanoparticles in Real Functionalized System

Gunathilaka,

Shimomura

2024

Molecules

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“…Other transition metals are known to pair favorably through coordination interactions with the lone pairs of 2D bP, to form functional 2D bP/metal nanoparticles systems. In a more recent work [ 63 ] from our group, we reported the in situ functionalization of 2D bP with gold nanoparticles (Au NPs) through a deposition–precipitation solid–liquid heterogeneous reaction starting directly from a metalloorganic Au(I) precursor. In particular, the precursor containing a Cl − ligand and a labile dimethylsulfide ligand was easily reduced when in contact with 2D bP surface.…”

Section: Interface/surface Engineering For Selected Applicationsmentioning

confidence: 99%

“…e) Height profile of a typical step found on pristine bP measured along the dashed line shown in panel (a).f-h) Maximum vertical size distributions of Au NPs and clusters with respect to the BP plane in samples incubated for 3h f), 18h g), and 72h h). Reproduced with permission [63]. Copyright 2021, Royal Society of Chemistry.…”

mentioning

confidence: 99%

Smart Synthetic and Surface‐Engineering Approaches to Functionalize 2D Black Phosphorus for Real‐Setting Applications

Moschetto

Prescimone

Bolognesi

et al. 2022

Adv Materials Inter

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Phosphorene or 2D black phosphorus (2D bP) has attracted increasing attention within material scientists in the last decade due to its electronic and photophysical properties as a pristine material. Furthermore, the high chemical reactivity of 2D bP enables the engineering of the outermost superficial layers. This tailored functionalization allows to obtain 2D bP‐based systems such as heterostructures with multiple and/or nonstandard functional properties that can be straightforwardly exploited for real‐setting applications. The aim of this review is to summarize the state of the art on the different strategies in the functionalization of 2D bP such as chemical reactivity with organic molecules, decoration with metal and metal‐oxide nanoparticles, passivation with thin layers of metal oxides or polymers, van der Waals coupling with different inorganic 2D materials, blending into polymeric composites. The main physical and chemical properties of all the considered heterostructures and as‐realized derivatives of 2D bP, with a particular focus on the increase of stability in air, are described. Finally, the functional characteristics of each system which are correlated to and involved in the development of specific real‐setting applications, spanning from catalysis, to electronics and optoelectronics, to energy conversion and storage and biodiagnostics, are highlighted.

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“…They display strong light absorption through excitation of a localized surface plasmon resonance, along with the properties of strong light absorption, vigorous nature, recyclability, and high surface areas, which render the noble metals as good photocatalytic materials. [25][26][27][28] The noble metals can also passivate BP by chemical adsorption through making cation-p interactions. Indeed, BP acts as a reducing agent by losing its electrons and binding to the surface of metal ions.…”

Section: Introductionmentioning

confidence: 99%

Enhanced photocatalytic activity of modified black phosphorus-incorporated PANi/PAN nanofibers

et al. 2023

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Easy and fast in situ functionalization of exfoliated 2D black phosphorus with gold nanoparticles

Abstract: Heterostructures of single- and few-layer black phosphorus (2D bP) functionalized with gold nanoparticles (Au NPs) have been recently reported in the literature, exploiting their intriguing properties and biocompatibility for catalytic,...

Cited by 9 publications

References 67 publications

Nanoscale Evaluation of the Degradation Stability of Black Phosphorus Nanosheets Functionalized with PEG and Glutathione-Stabilized Doxorubicin Drug-Loaded Gold Nanoparticles in Real Functionalized System

Nanoscale Evaluation of the Degradation Stability of Black Phosphorus Nanosheets Functionalized with PEG and Glutathione-Stabilized Doxorubicin Drug-Loaded Gold Nanoparticles in Real Functionalized System

Smart Synthetic and Surface‐Engineering Approaches to Functionalize 2D Black Phosphorus for Real‐Setting Applications

Enhanced photocatalytic activity of modified black phosphorus-incorporated PANi/PAN nanofibers

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