Easy Preparation of Stable Iron Oxide Nanoparticles Using Gelatin as Stabilizing Molecules

Yonezawa, Tetsu; Kamoshita, Keigo; Tanaka, Masayoshi; Kinoshita, Takatoshi

doi:10.1143/jjap.47.1389

Cited by 19 publications

(10 citation statements)

References 16 publications

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“…For example, Gao et al reported the high‐temperature synthesis of water‐soluble 5 nm IONPs from Fe(acac) 3 and FeCl 3 ·6H 2 O by refluxing the precursors in 2‐pyrrolidone that served both as a solvent and a ligand 29, 30. Furthermore, Yonezawa et al proposed the synthesis of gelatine‐stabilized iron oxide nanoparticles from an Fe 3+ ‐gelatine complex using sodium borohydride (NaBH 4 ) 31. However, the above IONP‐synthesis methods fail to overcome one challenge: in spite of their dependence on stabilizing mole‐cules to control particle size, they should simultaneously tolerate the presence of biocompatible or functionalizable surfactant molecules; i.e., a simple, one‐pot method under mild conditions has yet to be developed.…”

Section: Introductionmentioning

confidence: 99%

“…Reducing the inorganic and organometallic precursors with NaBH 4 is a widely used method in the synthesis of metal nanoparticles such as gold, silver, iron, cobalt, and other, multicomponent nanoparticles 32–35. Surprisingly, reports describing the use of NaBH 4 as a reducing agent for the synthesis of metal oxide nanoparticles such as iron oxide are relatively rare 31…”

Section: Introductionmentioning

confidence: 99%

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A Versatile Method for the Reductive, One‐Pot Synthesis of Bare, Hydrophilic and Hydrophobic Magnetite Nanoparticles

Yathindranath

Rebbouh

Moore³

et al. 2011

Adv Funct Materials

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A biocompatible, reliable, and particularly versatile synthesis of magnetic iron oxide nanoparticles (IONPs) is presented that uses iron(III) acetylacetonate Fe(acac) 3 as an iron precursor and sodium borohydride as a reducing agent. Both the reaction temperature and the concentration of the reducing agent have considerable effects on the IONP size. These dependencies can be used to prepare IONPs ranging in size from 5 to 8 nm, as determined by transmission electron microscopy (TEM). Synthesis at room temperature or with higher sodium borohydride concentrations always resulted in smaller particle sizes. Powder X-ray diffraction patterns show the presence of an iron oxide phase with a cubic unit cell and allow for the determination of the lattice parameters and average crystallite sizes for all synthesized IONPs. Transmission Mössbauer spectroscopy shows that the as-synthesized IONPs are pure magnetite (Fe 3 O 4 ) and is further used to elucidate the reaction pathway by analyzing iron intermediates formed prior to nanoparticle formation and precipitation. TEM and high-resolution TEM reveal quasi-spherical shapes and lattice fringes for most IONPs. With only minor modifi cations of the synthesis procedure, this versatile, one-pot synthesis is proven to be suitable for the production of bare (uncoated) IONPs, IONPs with hydrophilic poly(ethylene glycol), L -arginine, and L -glutamic acid coatings, as well as IONPs with hydrophobic coatings such as oleic acid. All coated IONPs were characterized by FT-IR spectroscopy. In addition, the bare IONPs could easily be modifi ed post-synthesis with a suitable capping agent using ultrasonication. To verify the biocompatibility of the IONPs, in vitro cytotoxicity studies were carried out on bare IONPs with intestinal (Caco2) and liver epithelial (HepG2) cell cultures using an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Phase contrast microscopy after hematoxylin-eosin staining showed the intact morphology of the Caco2 and HepG2 cells treated with IONPs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Versatile Method for the Reductive, One‐Pot Synthesis of Bare, Hydrophilic and Hydrophobic Magnetite Nanoparticles

Yathindranath

Rebbouh

Moore³

et al. 2011

Adv Funct Materials

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“…Indeed, the energy of adsorption includes, in addition to a steric repulsion, an electrostatic contribution due to the interactions between sites of opposed charge on surface and polymer. In addition to the dextran, other natural polymers such as chitosan [69], gelatin [70], or pullulan [71] can allow obtaining magnetic ferrofluids.…”

Section: Stabilizationmentioning

confidence: 99%

Magnetic Iron Oxide Nanoparticles for Biomedical Applications

et al. 2010

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Due to their high magnetization, superparamagnetic iron oxide nanoparticles induce an important decrease in the transverse relaxation of water protons and are, therefore, very efficient negative MRI contrast agents. The knowledge and control of the chemical and physical characteristics of nanoparticles are of great importance. The choice of the synthesis method (microemulsions, sol-gel synthesis, laser pyrolysis, sonochemical synthesis or coprecipitation) determines the magnetic nanoparticle's size and shape, as well as its size distribution and surface chemistry. Nanoparticles can be used for numerous in vivo applications, such as MRI contrast enhancement and hyperthermia drug delivery. New developments focus on targeting through molecular imaging and cell tracking.

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“…In this regard, superparamagnetic iron oxide nanoparticles (SPIONs) such as magnetite (Fe 3 O 4 ) and maghemite (g-Fe 2 O 3 ) are the most promising candidates since their biocompatibility has already been proven [4][5][6]. Colloidal stability, i.e, the particles coated with various surfactants like proteins, amino acids, polymers etc., is also well studied [7][8][9][10][11][12][13][14][15], our own previous studies have shown that a single step in situ coprecipitation of iron chlorides in the presence of PVA by NH 4 OH is a simple route to obtain ferrofluids with high stability, saturation magnetization, and controlled morphology [16]. The whole process is said to mimic natural biomineralization reaction because of the innumerable possibilities of secondary bond formation to stabilize the system, PVA acts as a template and the process is termed ''biomimetic''.…”

Section: Introductionmentioning

confidence: 99%

Stability of biomimetic ferrofluids established by a systematic study using microwave irradiation at defined wattages

Bhattacharya

Jenamoni

Nayar

2012

Journal of Magnetism and Magnetic Materials

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Easy Preparation of Stable Iron Oxide Nanoparticles Using Gelatin as Stabilizing Molecules

Cited by 19 publications

References 16 publications

A Versatile Method for the Reductive, One‐Pot Synthesis of Bare, Hydrophilic and Hydrophobic Magnetite Nanoparticles

A Versatile Method for the Reductive, One‐Pot Synthesis of Bare, Hydrophilic and Hydrophobic Magnetite Nanoparticles

Magnetic Iron Oxide Nanoparticles for Biomedical Applications

Stability of biomimetic ferrofluids established by a systematic study using microwave irradiation at defined wattages

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