“…Furthermore,t he broad scope of this transformation was demonstrated by the labelling of deoxyadenosine (4), inosine (5), and nucleotides such as AMP (6), c-AMP (7), ADP (8)a nd ATP ( 9). Remarkably,d espite the coordination ability of phosphate groups for metallic nanoparticles,b oth selectivity and deuterium incorporation remained very high even in the case of ATPw hich contains at risphosphate moiety.I nterestingly,o nly slight changes in deuterium incorporation were observed depending on the pH of the solution for 9 (see Table S1 in the Supporting Information) highlighting the robustness of this new catalytic process.A nalogues like the deuterated xanthines 10, 11,a nd 12,w idely used as internal standards in qualitative or quantitative isotope dilution mass-spectrometry for antidoping controls, [14] were also obtained with ag ood deuterium incorporation and isotopic enrichment on the purine core (1.3 to 3.9 Di ncorporated). Fort hose compounds,t he additional labelling of the methyl group can be explained by ar emote CÀHactivation process facilitated by the proximity of the sp 3hybridized carbon center to the surface of the Ru nanocluster after the coordination of the nitrogen in position 9.…”