Easy-to-Use Colorimetric Cyanine Probe for the Detection of Cu2+ in Wilson’s Disease

Shi, Yibing; Wang, Rou-Min; Yuan, Wei; Liu, Qingyun; Shi, M.; Feng, Wei; Wu, Zhi‐Ying; Hu, Ke; Li, Fuyou

doi:10.1021/acsami.8b07081

Cited by 56 publications

(34 citation statements)

References 40 publications

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“…B UV-Vis-NIR absorption spectra (WD patients' urine/EtOH/HEPES = 10:10:1) of 10 lmol/L CYDA when the pH value was 6.8 (left), 8.0 (right), from top to bottom: CYDA/Urine start , CYDA/Urine end and Urine. Adapted from Shi et al (2018) REVIEW RhoNox to scrutinize Fe 2? release during endocytotic iron uptake (Niwa et al 2018).…”

Section: Fe 2?mentioning

confidence: 99%

Recent Endeavors on Molecular Imaging for Mapping Metals in Biology

et al. 2020

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Transition metals such as zinc, copper and iron play vital roles in maintaining physiological functions and homeostasis of living systems. Molecular imaging, including two-photon imaging (TPI), bioluminescence imaging (BLI) and photoacoustic imaging (PAI), could act as non-invasive toolkits for capturing dynamic events in living cells, tissues and whole animals. Herein, we review the recent progress in the development of molecular probes for essential transition metals and their biological applications. We emphasize the contributions of metallostasis to health and disease, and discuss the future research directions about how to harness the great potential of metal sensors. Graphic Abstract

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Section: Fe 2?mentioning

confidence: 99%

Recent Endeavors on Molecular Imaging for Mapping Metals in Biology

et al. 2020

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“…Also, Cu 2+ catalyzes the creation of reactive oxygen species which can harm basic biological molecules. According to various literatures, the toxicity of Cu 2+ has linked to severe neurological diseases [5], Indian childhood cirrhosis (ICC) and prion diseases [2,4,6,7]. World Health Organization (WHO) has reported that the optimum intake of Cu 2+ for adults SAVRAN et al/Turk J Chem should not go above the level of 10-12 mg.day −1 [8].…”

Section: Introductionmentioning

confidence: 99%

Fluorescent sensing platform for low-cost detection of Cu2+by coumarin derivative: DFT calculation and practical application in herbal and black tea samples

Savran¹,

Karagöz²,

Elmas³

et al. 2020

Turk J Chem

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A fluorogenic probe based on a coumarin-derivative for Cu 2+ sensing in CH 3 CN/H 2 O media (v/v, 95/5, 5.0 µM) was developed and applied in real samples. 3-(4-chlorophenyl)-6,7-dihydroxy-coumarin (MCPC) probe was obtained by synthetic methodologies and identified by spectral techniques. The probe MCPC showed remarkable changes with a "turn-off" fluorogenic sensing approach for the monitoring of Cu 2+ at 456 nm under an excitation wavelength of 366 nm. The response time of the probe MCPC was founded as only 1 min. The detection limit of the probe MCPC was recorded to be 1.47 nM. The binding constant and possible stoichiometric ratio (1:1) values were determined by Benesi-Hildebrand and Job's plot systems, respectively. The mechanism of the probe MCPC with Cu 2+ was further confirmed by ESI-MS and FT-IR analyses, as well as supported by theoretical calculations. Furthermore, the probe MCPC was successfully employed for the practical applications to sense Cu 2+ in different herbal and black tea samples. The proposed sensing method was also verified by ICP-OES method.

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“…Hence, optical probes that could detect Cu 2+ with colorimeter and fluorescence are in great demand since they offer simple, cost-effective methods for rapid and efficient detection of Cu 2+ concentrations. Fluorescent chemosensor, for example, oligo-thiophene-phenylamine based Schiff's bases, 9 ferrocenes based chemosensor, 10 N-benzoyl thioureas, 11 benzimidazole subsidiaries, 12 pyridine acyl thiourea subordinates 13, etc have been accounted for the detection of…”

Section: Introductionmentioning

confidence: 99%

A novel sensor for sequential and cellular detection of copper and lactic acid

Gour

Kharbanda²,

Pandey³

et al. 2020

Preprint

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<div> We report self assembling/aggregation properties of acyl-thiourea derivative, N-((6-methoxy-pyridin-2-yl)carbamothioyl)benzamide<a>(NG1) </a><a>[i1]</a> and the disaggregation induced emission which leads to its application as fluorescence and colorimetric probe for the sensitive detection of Cu2+. The microscopy analysis of NG1via SEM, and AFM reveal that it self-assembles to give fiber-like morphologies.Interestingly,NG1 also assembles to fluorescent fibers which show tunable emission properties. Addition of Cu2+to these fibers causedisruption/disaggregation of fibers and a golden yellow fluorescence is produced due to disaggregation induced emission enhancement (DIEE). The application of NG1 as selective sensor for copper was further assessed by UV visible and fluorescence spectroscopy. Limit of Detection(LOD) of Cu2+ with colorimetry was 2.5ppm while LOD of Cu2+ with fluorescence was as low as 0.1ppm. This yellow fluorescence is quenched after the addition of lactic acid and hence NG1 could potentially be used for the sequential detection of both Cu and lactate.Further, structural modification of the probe NG1 suggest crucial role of both pyridine and acyl-thiourea moiety in the binding of Cu2+. The experimental results of interaction of NG1 with Cu2+ and lactate were also validated theoretically by quantum chemical calculations based on density functional theory (DFT). Finally, we explore the ability of NG1for the sequential detection of Cu2+ and lactate in cells, which suggestsNG1 can be used effectively for the cellular imaging applications and to selectively sense Cu2+. To, the best of our knowledge,</div> this is the first report wherein a dual sensor for Cu2+and lactate ion is synthesized and it may in allpossibilities pave the way for the diagnosis of Cu2+associated disorders like Wilson’s disease and in the detection of elevated lactate levels which are associated with the wide range of pathologies likemitochondrial diseases, cerebral ischemia and cancer. <div> </div>

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Easy-to-Use Colorimetric Cyanine Probe for the Detection of Cu²⁺ in Wilson’s Disease

Cited by 56 publications

References 40 publications

Recent Endeavors on Molecular Imaging for Mapping Metals in Biology

Recent Endeavors on Molecular Imaging for Mapping Metals in Biology

Fluorescent sensing platform for low-cost detection of Cu2+by coumarin derivative: DFT calculation and practical application in herbal and black tea samples

A novel sensor for sequential and cellular detection of copper and lactic acid

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