Easy‐to‐use prediction model for postherpetic neuralgia

Kinouchi, Motoshi; Igawa, Satomi; Ohtsubo, Sawa; Doi, Haruki; Honma, Masaru

doi:10.1111/1346-8138.16091

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…More than 50% of all cases of HZ occur in the chest and back [3]. Postherpetic neuralgia (PHN) refers to pain in the herpes area that lasts for more than 3 months after herpes caused by varicella-zoster virus subsides or scabs [4]. Chronic neuropathic pain may last for more than one year in approximately 10 to 25% of patients [5].…”

Section: Introductionmentioning

confidence: 99%

Diffusion-Weighted Imaging of the Dorsal Root Ganglion as a Quantitative Biomarker Reflecting the Severity and Prognosis of Herpes Zoster:A Prospective Magnetic Resonance Imaging Study

Shen,

Dai,

Liu

et al. 2024

Preprint

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Section: Introductionmentioning

confidence: 99%

Diffusion-Weighted Imaging of the Dorsal Root Ganglion as a Quantitative Biomarker Reflecting the Severity and Prognosis of Herpes Zoster:A Prospective Magnetic Resonance Imaging Study

Shen,

Dai,

Liu

et al. 2024

Preprint

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Diffusion-weighted imaging of the dorsal root ganglion as a quantitative biomarker reflecting the severity and prognosis of herpes zoster：a prospective magnetic resonance imaging study

Shen,

Dai,

Liu

et al. 2023

Preprint

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This prospective study aimed to characterize diffusion-weighted imaging (DWI) of the dorsal root ganglion (DRG) in herpes zoster (HZ) and to investigate the apparent diffusion coefficient (ADC) as a quantitative evaluation indicator for HZ as well as a predictor for postherpetic neuralgia (PHN). Thirty-six patients with HZ and ten healthy volunteers underwent magnetic resonance imaging (MRI) scanning. The ADC values of the affected and symmetric asymptomatic DRG were collected and compared. The rash intensity (RI), visual analog scale (VAS), pain index (PI), insomnia severity index (ISI), self-rated anxiety scale (SAS) and self-rated depression scale (SDS) were used to assess clinical characteristics. DWI analysis showed that ADC values of symptomatic DRG were significantly lower than those of symmetric asymptomatic DRG in both the HZ-period (P < 0.001) and the follow-up period (P < 0.001). The ADC value difference of the bilateral DRG at the affected segment (asymptomatic value – symptomatic value) was correlated with several clinical data in the HZ period. Analysis of the receiver operating characteristic curve revealed that the HZ-period ADC value difference had a high predictive value for PHN (Area under the curve = 0.815, P = 0.003). The cutoff value was 0.121 × 10–3mm2/s. DWI of the DRG can quantitatively display the change in the affected DRG in HZ patients and may indicate nerve necrosis and structural variation of the neuronal cell membrane. DWI of the DRG can help evaluate the clinical status of patients with HZ and may be a potential prognostic indicator for the occurrence of PHN.

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Easy‐to‐use prediction model for postherpetic neuralgia

Cited by 2 publications

References 6 publications

Diffusion-Weighted Imaging of the Dorsal Root Ganglion as a Quantitative Biomarker Reflecting the Severity and Prognosis of Herpes Zoster:A Prospective Magnetic Resonance Imaging Study

Diffusion-Weighted Imaging of the Dorsal Root Ganglion as a Quantitative Biomarker Reflecting the Severity and Prognosis of Herpes Zoster:A Prospective Magnetic Resonance Imaging Study

Diffusion-weighted imaging of the dorsal root ganglion as a quantitative biomarker reflecting the severity and prognosis of herpes zoster：a prospective magnetic resonance imaging study

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