Eating, diet, and nutrition for the treatment of non-alcoholic fatty liver disease

Abstract

Shire, speaker fees from Bristol-Myers Squibb, Falk, Gilead, Intercept and MSD, as well as travel support from AbbVie, Falk, Gilead, and Intercept. He is also co-inventor of patents on the medical use of 24-norursodeoxycholic acid. List of abbreviations: BMIbody mass index; CAPcontrolled attenuation parameter; DNLde-novo lipogenesis; HCDhigh-carbohydrate diet; IFintermittent fasting; IHLCintrahepatic lipid content; LCDlow-carbohydrate diet; LSMliver stiffness measurement; MD -Mediterranean diet; MUFAmono-unsaturated fatty acids; NAFLDnon-alcoholic fatty liver disease; NASHnon-alcoholic steatohepatitis; PUFApoly-unsaturated fatty acids; RCTrandomized controlled trial; SFAsaturated fatty acids; SSB -Sugar-sweetened beverages; TRFtime-restricted feeding;

Diet and non-alcoholic fatty liver disease, a short narrative review

“…Several detailed reviews provide an extended and in depth background on the evidence for the use of certain diets in NAFLD (15,16,37). Evidence can be briefly summarised as follows:…”

Correspondence on Letter regarding “Risk factors in nonalcoholic fatty liver disease”

“…4 Numerous epidemiological studies have also indicated a dose-response relationship between sugar-sweetened beverage consumption and both NAFLD prevalence and incidence. 5 Consumption of fructose causes harmful changes to the composition of the gut microbiome. 6 The Framingham Heart Study reconfirmed that frequent consumers of sweetened beverages face a significantly elevated risk of developing NAFLD compared to non-consumers.…”

“…The National Health and Nutrition Examination Survey (NHANES) data have demonstrated a link between increased added sugar consumption and a higher prevalence of NAFLD and obesity [ 4 ]. Numerous epidemiological studies have also indicated a dose-response relationship between sugar-sweetened beverage consumption and both NAFLD prevalence and incidence [ 5 ]. Consumption of fructose causes harmful changes to the composition of the gut microbiome [ 6 ].…”

Effect of Nut Consumption on Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

“…Currently, pharmacological treatments for NAFLD lack both safety and efficacy, and lifestyle interventions such as weight loss, a balanced diet, and physical exercise remain among the best treatments for NAFLD [ 2 ]. A growing number of studies have shown a negative correlation between the Mediterranean diet and the incidence of NAFLD [ 3 ]. The Mediterranean diet, characterized by a high content of polyphenols, carotenoids, vitamins, and polyunsaturated fats, has anti-inflammatory and antioxidant effects, and has been shown to be highly effective in reducing the risk of metabolic syndrome [ 4 ].…”