BackgroundIn this study, we seek to further explore the role of COVID-19 pandemic-related stress, social support, and resilience on self-reported eating disorder symptoms (using the EDE-QS) and perceived weight gain among lesbian, gay, bisexual, transgender and/or queer (LGBTQ+ adults) in the US context during the COVID-19 pandemic. MethodsEmploying a convergent mixed method design, we surveyed 411 individuals, and conducted qualitative semi-structured follow-up interviews with 43 LGBTQ+-identifying survey respondents. Using OLS regression and multinomial logistic regression, we modeled eating disorder symptoms and perceived weight gain among LGBTQ+ individuals (n=120) and cisgender and heterosexual-identifying women (n=230), to cisgender and heterosexual-identifying men (n=61). We also explored complementary interview narratives among LGBTQ+ people by employing selective coding strategies. ResultsStudy results suggest that LGBTQ+ individuals are likely experiencing uniquely high levels of pandemic-related stress, and secondly, that pandemic-related stress is associated with elevated eating disorder symptoms and higher risk of perceived weight gain. Nearly 1 in 3 participants reported eating disorder symptoms of potentially clinical significance. Social support, but not resilient coping, was found to be protective against increased eating disorder symptoms. Qualitative analyses revealed that LGBTQ+ individuals situated physical exercise constraints, challenging eating patterns, and weight concerns within their pandemic experiences. ConclusionsClinicians of diverse specialties should screen for eating disorder symptoms and actively engage patients in conversations about their COVID-19 related weight gain and eating behaviors, particularly with LGBTQ+-identifying adults.