ObjectiveThe association between eating disorders (EDs) and harmful substance use (substance use that causes psychosocial impairment) is well recognized in the literature, and military veterans may be at heightened risk for both issues due to deployment‐related stressors. However, little is known about which ED‐related symptoms are associated with harmful substance use in veterans, and whether gender plays a differential role in this relationship. Our aims were to: (1) examine gender differences in ED‐related symptoms; and (2) examine whether ED‐related symptoms differentially predict harmful substance use in US veteran men and women who had recently separated from service.MethodThis study was based on a nationally representative four‐wave longitudinal sample of post‐9/11 veterans (N = 835; 61.2% female). Longitudinal mixed modeling was used to test whether specific ED‐related behaviors at baseline predicted harmful substance use at follow‐ups.ResultsWe replicated gendered patterns of ED‐related symptoms observed in civilian populations, wherein men had higher weight‐and‐body‐related concerns (including excessive exercise and muscle building) and negative attitude toward obesity, and women had higher bulimic and restricting symptoms. For women, alcohol, drug, and marijuana problems were predicted by higher bulimic symptoms, whereas for men, these problems were predicted by higher restricting symptoms.ConclusionGender played a differential role in the relationship between EDs and harmful substance use. Bulimic symptoms were the most robust predictor for harmful substance use among veteran women, whereas restricting was the most robust predictor for harmful substance use among veteran men.Public SignificanceThe current study found that veteran women had higher bulimic symptoms (characterized by binge eating and purging) and restricting than veteran men. In women, bulimic symptoms predicted future harmful use of alcohol, marijuana, and other drugs. In contrast, veteran men had higher weight‐and‐body‐related concerns (characterized by excessive exercise and muscle building) than veteran women. In men, restricting symptoms predicted future harmful use of alcohol, marijuana, and other drugs.