Eating disorders and the skin

Strumìa, Renata

doi:10.1016/j.clindermatol.2011.11.011

Cited by 55 publications

(50 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Eating disorders such as anorexia nervosa and bulimia nervosa may result in significant medical complications in all of the primary human organ systems, including the skin . Among a large spectrum of skin diseases, level C information provided evidence that acne may be associated with eating disorders …”

Section: Resultsmentioning

confidence: 99%

Acne and nutrition: hypotheses, myths and facts

Claudel¹,

Auffret²,

Leccia

et al. 2018

Acad Dermatol Venereol

View full text Add to dashboard Cite

Acne is an inflammatory and multifactorial skin disease. Different external and internal factors, including air pollution, aggressive skincare products, medication, mechanical, hormonal and familial factors and, more recently, lifestyle and stress, have been suggested as having an impact on acne. Moreover, for many years nutrition was believed to cause or worsen acne. Over the last decades, however, it has become a dermatological doctrine that there is no direct association between diet and acne. Even if recent research has allowed to identify certain nutritional elements and behaviour that may impact on acne, including the excessive intake of dairy products and hyperglycaemic food, modern lifestyle nutrition, obesity and eating disorders, knowledge about the role of nutrition in the physiopathology of acne still remains sparse and hypotheses and myths continue to dominate the debate. Thus, further clinical and translational research is necessary to investigate and confirm the association between nutrition and acne.

show abstract

Section: Resultsmentioning

confidence: 99%

Acne and nutrition: hypotheses, myths and facts

Claudel¹,

Auffret²,

Leccia

et al. 2018

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…In humans, consumption of excessive calories is associated with an increased incidence of type 2 diabetes, obesity, cardiovascular disease, and other disorders and diseases (Azadbakht et al 2012; Goncalves et al 2012; Naja et al 2012); while insufficient caloric intake is correlated with abnormal liver function and other disorders (Harris et al 2012; Strumia 2013). In spite of this, little is known about the genetic architecture underlying naturally occurring variation in food intake.…”

Section: Introductionmentioning

confidence: 99%

Genetic and Genomic Response to Selection for Food Consumption in Drosophila melanogaster

et al. 2016

View full text Add to dashboard Cite

Food consumption is an essential component of animal fitness; however, excessive food intake in humans increases risk for many diseases. The roles of neuroendocrine feedback loops, food sensing modalities, and physiological state in regulating food intake are well understood, but not the genetic basis underlying variation in food consumption. Here, we applied ten generations of artificial selection for high and low food consumption in replicate populations of Drosophila melanogaster. The phenotypic response to selection was highly asymmetric, with significant responses only for increased food consumption and minimal correlated responses in body mass and composition. We assessed the molecular correlates of selection responses by DNA and RNA sequencing of the selection lines. The high and low selection lines had variants with significantly divergent allele frequencies within or near 2,081 genes and 3,526 differentially expressed genes in one or both sexes. A total of 519 genes were both genetically divergent and differentially expressed between the divergent selection lines. We performed functional analyses of the effects of RNAi suppression of gene expression and induced mutations for 27 of these candidate genes that have human orthologs and the strongest statistical support, and confirmed that 25 (93%) affected the mean and/or variance of food consumption.

show abstract

“…1 It has been speculated that the rash is the result of bone marrow depression from starvation and subsequent thrombocytopenia. 2 This explanation does not fit our patient's case, however, given his normal blood work. Weakening of capillary walls and dermal supporting structures related to malnutrition is a more plausible explanation for the findings in our patient.…”

mentioning

confidence: 38%

“…Weakening of capillary walls and dermal supporting structures related to malnutrition is a more plausible explanation for the findings in our patient. 1,2 Although this striking rash is uncommon, medical practitioners may wish to keep it in mind as a potential manifestation of severe anorexia nervosa. A B…”

mentioning

confidence: 99%

Diffuse reticulate purpura in a boy with anorexia nervosa

Colmenero

Fernández

2015

CMAJ

View full text Add to dashboard Cite

A 14-year-old boy presented to the emergency department with a one-week history of asymptomatic, diffuse, reticulate, purpuric macules over his trunk. The iliac crests were spared by the rash ( Figure 1A). The patient's parents reported that he had lost 12 kg over the preceding two months from a baseline of about 50 kg (at a height of 160 cm). He was bradycardic (49 beats/min) and hypotensive (96/47 mm Hg), with cold extremities and pitting edema of the lower legs. Our differential diagnosis included scurvy, vasculitis and coagulation abnormalities.The patient's electrolyte levels, hemoglobin concentration, leukocyte count, albumin level, transaminase levels, coagulation profiles, serum vitamin B 12 level, folic acid level, ascorbic acid level and renal function were all within normal limits. Skin biopsy showed focal erythrocyte extravasation in the dermis without vasculitis or vascular damage ( Figure 1B).During the patient's subsequent hospital admission, we diagnosed anorexia nervosa in consultation with our psychiatric team. With adequate nutritional supply and energy intake, the patient gained weight, and after one month, the rash was gone. At a six-month follow-up, the rash had not returned, and the patient was still receiving psychiatric treatment.Severe and rapid weight loss is a critical problem in adolescence. In the context of severe malnutrition, the presence of a purpuric rash may be a warning of impending decompensation. 1 It has been speculated that the rash is the result of bone marrow depression from starvation and subsequent thrombocytopenia. 2 This explanation does not fit our patient's case, however, given his normal blood work. Weakening of capillary walls and dermal supporting structures related to malnutrition is a more plausible explanation for the findings in our patient. 1,2 Although this striking rash is uncommon, medical practitioners may wish to keep it in mind as a potential manifestation of severe anorexia nervosa. Clinical imagesDiffuse reticulate purpura in a boy with anorexia nervosa

show abstract

Eating disorders and the skin

Cited by 55 publications

References 25 publications

Acne and nutrition: hypotheses, myths and facts

Acne and nutrition: hypotheses, myths and facts

Genetic and Genomic Response to Selection for Food Consumption in Drosophila melanogaster

Diffuse reticulate purpura in a boy with anorexia nervosa

Contact Info

Product

Resources

About