EAU Penile Cancer Guidelines 2009

Pizzocaro, Giorgio; Algaba, Ferrán; Horenblas, Simon; Solsona, E.; Tana, S.; Poel, H. Van Der; Watkin, N.

doi:10.1016/j.eururo.2010.01.039

Cited by 353 publications

(291 citation statements)

References 61 publications

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“…Specific measurements of depth of invasion are not included in the definition [157]. Some authors stratify T1 tumors by grade into low-, intermediate-, and high-risk categories, recommending lymphadenectomy for high-risk (T1G3) lesions, surveillance for low-risk (T1G1) lesions, and consideration of lymphadenectomy for intermediate-risk (T1G2) lesions, potentially including growth pattern and presence of LVI as points of consideration in the decision [158]. Scrotum.-Squamous cell carcinoma of the scrotum is now very rare.…”

Section: Site-specific Recommendationsmentioning

confidence: 99%

The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: Background and Consensus Recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology

Darragh

Colgan

Cox

et al. 2012

Archives of Pathology &Amp; Laboratory Medicine

641

372

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The terminology for human papillomavirus (HPV)–associated squamous lesions of the lower anogenital tract has a long history marked by disparate diagnostic terms derived from multiple specialties. It often does not reflect current knowledge of HPV biology and pathogenesis. A consensus process was convened to recommend terminology unified across lower anogenital sites. The goal was to create a histopathologic nomenclature system that reflects current knowledge of HPV biology, optimally uses available biomarkers, and facilitates clear communication across different medical specialties. The Lower Anogenital Squamous Terminology (LAST) Project was cosponsored by the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology and included 5 working groups; 3 work groups performed comprehensive literature reviews and developed draft recommendations. Another work group provided the historical background and the fifth will continue to foster implementation of the LAST recommendations. After an open comment period, the draft recommendations were presented at a consensus conference attended by LAST work group members, advisors, and representatives from 35 stakeholder organizations including professional societies and government agencies. Recommendations were finalized and voted on at the consensus meeting. The final, approved recommendations standardize biologically relevant histopathologic terminology for HPV-associated squamous intraepithelial lesions and superficially invasive squamous carcinomas across all lower anogenital tract sites and detail the appropriate use of specific biomarkers to clarify histologic interpretations and enhance diagnostic accuracy. A plan for disseminating and monitoring recommendation implementation in the practicing community was also developed. The implemented recommendations will facilitate communication between pathologists and their clinical colleagues and improve accuracy of histologic diagnosis with the ultimate goal of providing optimal patient care.

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Section: Site-specific Recommendationsmentioning

confidence: 99%

The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: Background and Consensus Recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology

Darragh

Colgan

Cox

et al. 2012

Archives of Pathology &Amp; Laboratory Medicine

641

372

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“…Systemic therapy is typically chemotherapy; data from a single-arm phase II trial supports the use of paclitaxel, ifosfamide, and platinum (TIP) as neoadjuvant therapy for patients with clinical evidence of nodal involvement [4]. For metastatic disease, TIP is also the preferred first-line regimen, although historical regimens such as 5-fluorouracil with cisplatin may also be considered [5]. Cetuximab has been seen to be active in a subset of patients with PSCC; one patient in one non-epidermal growth factor receptor (EGFR)-stratified series had a response rate of 23.5% to cetuximab with chemotherapy backbone [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Genomic Profiling of Advanced Penile Carcinoma Suggests a High Frequency of Clinically Relevant Genomic Alterations

Ali¹,

Pal

Wang³

et al. 2015

The Oncologist

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Background. Advanced penile squamous cell carcinoma (PSCC) is associated with poor survival due to the aggressiveness of the disease and lack of effective systemic therapies. Comprehensive genomic profiling (CGP) was performed to identify clinically relevant genomic alterations (CRGAs). Materials and Methods. DNA was extracted from 40 mm of formalin-fixed, paraffin-embedded sections in patients with advanced PSCC. CGP was performed on hybridizationcaptured, adaptor ligation-based libraries to a mean coverage depth of 6923 for 3,769 exons of 236 cancerrelated genes plus 47 introns from 19 genes frequently rearranged in cancer. CRGAs were defined as genomic alterations (GAs) linked to targeted therapies on the market or under evaluation in mechanism-driven clinical trials.

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“…In the 2001 guidelines [19] , no studies are cited even though at least three were available. In 2004 [20] , the Italian study [14] is cited and in 2009 [1] the Swedish and second Brazilian studies [11,13] are cited although the Italian study is omitted. Such inconsistences and the limited number of studies used in the guidelines could be viewed as an indication that more good quality, in depth data are required.…”

Section: Resultsmentioning

confidence: 99%

“…Penile cancer is rare in western populations, with world standardised rates ranging from 0.5 to 1.6 new registrations annually per 100,000 men [1] . Although it has a low incidence rate, penile cancer is a destructive disease.…”

Section: Introductionmentioning

confidence: 99%

Clinical practice as research for a rare condition: systematic research review of qualitative research exploring patients’ experiences of penile cancer

Branney

Raine²,

Witty³

et al. 2013

Clinical Nursing Studies

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Background: Penile cancer is a rare but destructive malignancy. The aim of this study was to identify published qualitative research exploring patients' experiences of being diagnosed and treated for penile cancer. As only one study met our inclusion criteria and yet there were five borderline studies, a secondary aim that emerged was to discuss those studies to see what, if anything, we could learn. Methods:We searched ASSIA, CINAHL, EMBASE, PUBMED/MEDLINE, PsycINFO & Web of Science and found 313 papers published since 1990. Two reviewers independently selected 17 papers for potential inclusion using titles and abstracts, which were obtained and independently assessed. A synthesis was not possible as only one study met our inclusion criteria. Five borderline studies, covering 4 countries, invited closer inspection because they are often reported in guidelines on penile cancer. Results:The 5 borderline studies reported using a mixed methods design combining a psychometric measure with interviews. Unfortunately, none of these studies reported the method or process used for analysing qualitative data or for integrating the interview and psychometric findings, making it difficult to understand the interview element of their research. Conclusions:If we are to understand and improve the long-term consequences of treatment for penile cancer, qualitative studies of patients' experiences need to be conducted with high quality analysis and reporting. While pen-and-paper questionnaires may take up little of the time of clinicians conducting research about rare conditions, time could be better used by using methodologies that explore patients experiences.

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EAU Penile Cancer Guidelines 2009

Cited by 353 publications

References 61 publications

The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: Background and Consensus Recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology

The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: Background and Consensus Recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology

Comprehensive Genomic Profiling of Advanced Penile Carcinoma Suggests a High Frequency of Clinically Relevant Genomic Alterations

Clinical practice as research for a rare condition: systematic research review of qualitative research exploring patients’ experiences of penile cancer

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