Ebv and HHV-6 Circulating Subtypes in People Living With Hiv in Burkina Faso, Impact on Cd4 T Cell Count and Hiv Viral Load

Traoré, Lassina; Nikiema, Ouéogo; Ouattara, Abdoul Karim; Compaoré, Tegwinde Rebeca; Soubeïga, Serge Théophile; Diarra, Birama; Obiri‐Yeboah, Dorcas; Sorgho, Pegdwendé Abel; Djigma, Florencia Wendkuuni; Bisseyé, Cyrille; Yonli, Albert Théophane; Simporé, Jacques

doi:10.4084/mjhid.2017.049

Cited by 12 publications

(7 citation statements)

References 51 publications

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“…Moreover, there was significant predominance of males among infected children. Similar results were reported from previous study from Burkina Faso with more prevalence of EBV and HHV6 in male patients below 5 years [34] .…”

Section: Primers and Probes Sequences Virussupporting

confidence: 91%

Study of Epstein Barr virus, Human Herpes 6 and Human Herpes 7 in Children with Acute Lymphoblastic Leukemia

Rizk¹,

Darwish²

2019

Int.J.Curr.Microbiol.App.Sci

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Section: Primers and Probes Sequences Virussupporting

confidence: 91%

Study of Epstein Barr virus, Human Herpes 6 and Human Herpes 7 in Children with Acute Lymphoblastic Leukemia

Rizk¹,

Darwish²

2019

Int.J.Curr.Microbiol.App.Sci

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“…We also show that the risk of HIV/EBV-1/2 multiple infection was higher in patients with longer HIV-1 infection, which emphasizes our warning because coinfections are common in patients who start treatment late, have the highest associated risk rate, and are also correlated with advanced clinical disease stages 117 , 118 . For EBV, this becomes more specific because the prevalence of EBV-1 and of multiple infection predominate in the most immunosuppressed patients; however, it is not known which factors may be involved in this scenario 44 , 119 .…”

Section: Discussionmentioning

confidence: 99%

Epidemiological risk factors associated with primary infection by Epstein–Barr virus in HIV-1-positive subjects in the Brazilian Amazon region

Pereira

França

Costa

et al. 2021

Sci Rep

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To identify the prevalence and risk factors for primary Epstein–Barr virus (EBV) infection in human immunodeficiency virus (HIV)-1-positive adult treatment-naïve patients between January 2018 and December 2019 in a state of the Brazilian Amazon region. A total of 268 HIV-1 positive patients and 65 blood donors participated in the study. Epidemiological data were obtained from medical records and through a designed questionnaire. EBV infection was screened by the semiquantitative detection of anti-viral capsid antigen (VCA) EBV IgM and IgG, followed by molecular detection of the EBNA-3C gene. The plasma viral loads of HIV-1 and EBV were quantified using a commercial kit. The prevalence of primary coinfection was 7.12%. The associated risk factors were education level, family income, history of illicit drug use and sexually transmitted infections, homosexual contact and condom nonuse. Approximately 58.5% had late initiation of highly active antiretroviral therapy, which influenced the risk of HIV-EBV 1/2 multiple infection (odds ratio (OR): 4.76; 95% CI 1.51–15.04) and symptom development (p = 0.004). HIV viral load was associated with patient age (OR: 2.04; 95% CI 2.01–2.07; p = 0.026) and duration of illicit drug use (OR: 1.57; 95% CI 1.12–2.22; p = 0.0548). EBV viral load was associated with younger age (OR: 0.82; 95% CI 0.79–1.03; p = 0.0579). The replication of both viruses was associated with symptom development (HIV = OR: 2.06; 95% CI 1.22–3.50; p = 0.0073; EBV = OR: 8.81; 95% CI 1–10; p = 0.0447). The prevalence of HIV/EBV coinfection was lower than that observed in other studies, and social vulnerability and promiscuous sexual behavior were associated risk factors. A long time of HIV-1 infection, without therapy, influenced the risk of coinfection and disease progression. The viral loads of both viruses may be associated with some epidemiological aspects of the population.

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“…HIV-positive patients on a highly active antiretroviral treatment would not act on a herpes virus infection but could prevent the reactivation of these viruses. 21 In an EBV infection, HAART treatment to improve CD4+ T cell restoration while contributing to lower HIV viral load does not affect. 22 A herpesvirus infection is more likely to be found in HAART patients with high CD4 T cell counts.…”

Section: Discussionmentioning

confidence: 99%

<p>First Report on HHV-6 Infection Among HIV-Infected Individuals Residing in Surabaya, Indonesia</p>

Oktafiani¹,

Megasari²,

Ana³

et al. 2020

HIV

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Background: Morbidity and mortality from acquired immunodeficiency syndrome (AIDS) are often associated with the reactivation of a herpes virus infection. Human herpesvirus-6 (HHV-6) is usually common in childhood infections that remain latent and can act as opportunists during immunosuppression to reactivate and cause disease. In human immunodeficiency virus (HIV)-infected patients, the impact of HHV-6 infection can be an upregulator of HIV replication and accelerate progress towards AIDS. However, studies on HHV-6 infection have never been done in Surabaya, Indonesia. Purpose: To determine the presence of HHV-6 infection among HIV-infected individuals residing in Surabaya, Indonesia. Patients and Methods: Plasma and peripheral blood mononuclear cells (PBMCs) were collected from 85 HIV-infected individuals in Universitas Airlangga Hospital, Surabaya, as well as 85 healthy controls. DNA extracted from PBMCs was subjected to PCR to determine HHV-6 infection, while plasma of HIV-infected individuals was used for viral RNA quantification using real-time PCR. Results: HHV-6 infection was detected in 17.6% (15/85) of HIV-infected individuals, and in 3.53% (3/85) of healthy controls. Thus, HHV-6 infection was more likely to be found in HIVinfected individuals than in healthy controls (odds ratio 5.85; 95% confidence interval, 1.6-21). The HHV-6B was the most common subtype identified in both HIV-infected individuals (12/15) and healthy controls (3/3). The HHV-6A and co-infection between HHV-6A and HHV-6B were only found in HIV-infected individuals (2/15 and 1/15, respectively). Viral RNA load of HIV-infected individuals was not correlated to HHV-6 infection. Conclusion: Our results indicate the emergence of HHV-6 infection among HIV-infected individuals residing in Surabaya, Indonesia, and the risk of HHV-6 infection was higher in HIV-infected individuals than in healthy controls.

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Ebv and HHV-6 Circulating Subtypes in People Living With Hiv in Burkina Faso, Impact on Cd4 T Cell Count and Hiv Viral Load

Cited by 12 publications

References 51 publications

Study of Epstein Barr virus, Human Herpes 6 and Human Herpes 7 in Children with Acute Lymphoblastic Leukemia

Study of Epstein Barr virus, Human Herpes 6 and Human Herpes 7 in Children with Acute Lymphoblastic Leukemia

Epidemiological risk factors associated with primary infection by Epstein–Barr virus in HIV-1-positive subjects in the Brazilian Amazon region

<p>First Report on HHV-6 Infection Among HIV-Infected Individuals Residing in Surabaya, Indonesia</p>

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