EBV Infection and Glucose Metabolism in Nasopharyngeal Carcinoma

Zhang, Jun; Jia, Lin; Tsang, Chi Man; Tsao, Sai Wah

doi:10.1007/978-981-10-5765-6_6

Cited by 44 publications

(29 citation statements)

References 67 publications

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“…It has been shown that the initiation and progress of NPC is closely associated with the status of Epstein-Barr virus (EBV) infection ( 67 ). Some EBV gene products are involved in tumor progression and play a vital part in epithelial-mesenchymal transition, angiogenesis and metastasis in NPC ( 67 , 68 ). The APOL1 gene may have a limited contribution to the initiation and progress of NPC.…”

Section: Discussionmentioning

confidence: 99%

The clinical significance of apolipoprotein L1 in head and neck squamous cell carcinoma

Zhong¹,

Chen

et al. 2020

Oncol Lett

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Approximately 500,000 new head and neck squamous cell carcinoma (HNSCC) cases are detected every year around the world, and its incidence ranks sixth among all cancer types globally. Among these cases, oral squamous cell carcinoma (OSCC) and laryngeal squamous cell carcinoma (LSCC) are HNSCC subtypes with high incidence rates, especially in China. The present study examines the association between the apolipoprotein L1 (APOL1) mRNA and protein expression and clinical parameters in HNSCC. The two most common types (oral and larynx) of HNSCC were selected for subgroup analyses. Immunohistochemistry (IHC) was used to detect APOL1 protein expression levels in HNSCC clinical specimens. It was demonstrated that APOL1 protein expression in 221 cases of HNSCC was higher compared with that in normal tissues. Consistent upregulation of APOL1 protein was also found in subgroups of OSCC and LSCC. Through mining the ArrayExpress, The Cancer Genome Atlas and the Gene Expression Omnibus databases, microarrays and RNA sequencing data for HNSCC were retrieved, which were used to analyze APOL1 mRNA expression levels. The results showed that APOL1 expression was higher in both OSCC and LSCC subtypes, as well as in HNSCC, compared with that in non-cancerous squamous epithelium. The summary receiver operating characteristic analysis showed that APOL1 had potential as a diagnostic biomarker for HNSCC, OSCC and LSCC. Thus, upregulation of APOL1 may contribute to the tumorigenesis of HNSCC.

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Section: Discussionmentioning

confidence: 99%

The clinical significance of apolipoprotein L1 in head and neck squamous cell carcinoma

Zhong¹,

Chen

et al. 2020

Oncol Lett

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“…Most of the nasopharyngeal carcinoma is low or undifferentiated squamous carcinoma, which is characterized by high malignancy, rapid growth, and distant metastasis [12]. Epidemiology studies revealed that the occurrence of NPC is closely related to EBV infection [13]. Some studies reported that TRAF2 was involved in EBV-associated nasopharyngeal carcinoma development.…”

Section: Introductionmentioning

confidence: 99%

TRAF2 Knockdown in Nasopharyngeal Carcinoma Induced Cell Cycle Arrest and Enhanced the Sensitivity to Radiotherapy

Zhu

Ding

et al. 2020

BioMed Research International

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TRAF2 is a crucial adaptor protein involved in various signaling pathways. However, its biological functions in nasopharyngeal carcinoma (NPC) remain largely unknown. In the present study, we found that TRAF2 was overexpressed in nasopharyngeal carcinoma (NPC) cells. Knockdown of TRAF2 with shRNA significantly suppressed NPC cell proliferation and colony formation. The growth of xenograft tumor significantly reduced after TRAF2 was silenced. Conversely, the ectopic overexpression of TRAF2 significantly promoted cell proliferation and anchorage-independent growth. In TRAF2 knockdown cells, EGF-induced activation of transcriptional factors, including MSK1, CREB, and ATF2, markedly decreased. Accordingly, the transcriptional activity of AP-1 was substantially decreased in TRAF2-deficient cells. With the suppression of gene transcription, the expression of cyclin D1 was significantly impaired, which gave rise to the G0/G1 cell cycle arrest. Moreover, the overexpression of TRAF2 in NPC cells was associated with resistance to irradiation, and the potency of irradiation was substantially enhanced after TRAF2 was knocked down. Briefly, our studies demonstrated that TRAF2 had a crucial role in NPC development, and it might be of great potential to targeting TRAF2 for NPC prevention and treatment.

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“…Discussion NPC is a common malignant tumor in South China and Southeast Asia (16). The specific etiology of NPC is still unclear, however, it has been reported that NPC is related to EBV virus infection, and methylation of the parkin gene may also promote tumors of NPC (17,18). Although NPC patients are sensitive to radiotherapy, the prognosis of NPC patients is still poor due to recurrence and distant metastasis (19).…”

Section: Correlation Analysis Of Mir-34a and Ki67 Expression Levels Imentioning

confidence: 99%

Expression of miR‑34a and Ki67 in nasopharyngeal carcinoma and the relationship with clinicopathological features and prognosis

2019

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Expression levels of miR-34a and Ki67 in nasopharyngeal carcinoma (NPC) and the relationship with clinicopathological features and prognosis were studied. A prospective study was performed on 56 cases of NPC tissues and 56 cases of adjacent tissues collected in Xiangyang No. 1 People's Hospital. The expression levels of miR-34a, Ki67 in NPC and adjacent tissues were detected by RT-qPCR. The association among the expression levels of miR-34a and Ki67, the clinicopathological features and prognosis of patients was analyzed. The relative expression levels of miR-34a in 56 cases of NPC were lower than those of the adjacent tissues. The expression of miR-34a in NPC was significantly associated with bone metastasis and TNM staging (P<0.001). The relative expression of Ki67 in 56 cases of NPC was higher than that of the adjacent tissues. The expression of Ki67 in NPC was significantly associated with lymphatic metastasis and TNM staging (P<0.001). The 5-year survival of patients with low expression of miR-34a was significantly lower than that of patients with high expression, and the survival of patients with high expression of Ki67 was significantly lower than that of patients with low expression. According to Pearson's correlation analysis, Ki67 expression was negatively correlated with miR-34a expression in NPC tissues. In conclusion, the expression of Ki67 in NPC was upregulated, while the expression of miR-34a in NPC was downregulated. miR-34a expression in NPC was significantly associated with bone metastasis and TNM staging, and Ki67 expression in NPC was significantly associated with lymphatic metastasis and TNM staging. In addition, there was a negative correlation between miR-34a and Ki67 expression levels, and the two can be used as predictors of NPC-associated mortality. The expression levels of miR-34a and Ki67, as well as TNM staging were associated with the prognosis of NPC patients.

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EBV Infection and Glucose Metabolism in Nasopharyngeal Carcinoma

Cited by 44 publications

References 67 publications

The clinical significance of apolipoprotein L1 in head and neck squamous cell carcinoma

The clinical significance of apolipoprotein L1 in head and neck squamous cell carcinoma

TRAF2 Knockdown in Nasopharyngeal Carcinoma Induced Cell Cycle Arrest and Enhanced the Sensitivity to Radiotherapy

Expression of miR‑34a and Ki67 in nasopharyngeal carcinoma and the relationship with clinicopathological features and prognosis

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