EBV positive fibrin/chronic inflammation associated diffuse large B-cell lymphoma: an incidental finding associated with a breast implant

Khoo, Christine; McTigue, Christine; Hunter-Smith, David J.; Walker, Patricia

doi:10.1016/j.pathol.2020.09.022

Cited by 16 publications

(19 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nineteen of them developed in breast implants. 14,[26][27][28][29][30][31][32] Eight cases developed in thrombus, vegetation, or hematoma associated with an intravascular implant (7 being arterial graft, 8,10,20,22 1 being a bovine mitral valve 22 ). The 2 remaining cases developed after knee replacement.…”

Section: Discussionmentioning

confidence: 99%

EBV-negative Fibrin-Associated Large B-Cell Lymphoma Arising in Thyroid Hyperplastic Nodule: Report of a Case and Literature Review

Cheuk

Chan

2023

Int J Surg Pathol

View full text Add to dashboard Cite

Fibrin-associated large B-cell lymphoma is a rare microscopic-sized tumor, typically representing an unexpected finding at sites rich in chronic fibrin deposition. It is associated with Epstein-Barr virus, and has been reported to occur in a wide variety of anatomic sites and clinical scenarios. We report a case arising in a thyroid hyperplastic nodule, only the second case reported in this location. Notably, this is only the fourth case of fibrin-associated large B-cell lymphoma that is not associated with Epstein-Barr virus. We provide a literature review on the clinico-pathological characteristics and outcome of this newly characterized indolent lymphoma type, which has only recently been separated out from the pathologically similar but highly aggressive large B-cell lymphoma associated with chronic inflammation.

show abstract

Section: Discussionmentioning

confidence: 99%

EBV-negative Fibrin-Associated Large B-Cell Lymphoma Arising in Thyroid Hyperplastic Nodule: Report of a Case and Literature Review

Cheuk

Chan

2023

Int J Surg Pathol

View full text Add to dashboard Cite

show abstract

“…This DLBCL is a lymphoid neoplasm frequently associated with EBV infection, initially described in Japan, and arises in the setting of longstanding chronic inflammatory process such as chronic osteomyelitis, pyothorax, metallic implant, or chronic skin ulcers [ 2 , 44 ]. Furthermore, it was also described in ileal neobladder, and related to breast implants [ 109 , 110 , 111 ]. The neoplastic cells have immunoblastic, centroblastic, or less commonly anaplastic features, with few nucleoli and limited to moderate amounts of cytoplasm.…”

Section: Dlbcl Associated With Chronic Inflammationmentioning

confidence: 99%

“…NGS in a series of chronic inflammation DLBCL associated with breast implant described mutations in genes known to be recurrently mutated in DLBCL, such as CREBBP, GNA13, TET2, IRF4, STAT3, and SOCS1 [ 110 ]. Latency III program is prevalent, since viral oncogenic antigens EBERs, LMP1, and EBNA-2 are positive in most cases, which may be related to the pathogenesis of this particular DLBCL subtype [ 44 , 111 ]. Chronic inflammation at the local site perhaps plays a role in the proliferation of EBV-transformed B cells, since it allows them to escape from the host immune surveillance, as a result of the production of immunosuppressive IL10 cytokine, and the autocrine to paracrine growth via IL6 and IL6R [ 2 ].…”

Section: Dlbcl Associated With Chronic Inflammationmentioning

confidence: 99%

Advances in the Pathogenesis of EBV-Associated Diffuse Large B Cell Lymphoma

Chabay

2021

Cancers

View full text Add to dashboard Cite

Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin’s lymphoma (NHL) in adults. Epstein–Barr virus (EBV) positive DLBCL of the elderly was defined by the World Health Organization (WHO) in 2008, it was restricted only to patients older than 50 years old, and it was attributed to immunesenescence associated with physiological aging. After the description of EBV-associated DLBCL in children and young adults, the WHO redefined the definition, leading to the substitution of the modifier “elderly” with “not otherwise specified” (EBV + DLBCL, NOS) in the updated classification, and it is no more considered provisional. The incidence of EBV + DLBCL, NOS varies around the world, in particular influenced by the percentage of EBV+ cells used as cut-off to define a case as EBV-associated. EBV has effect on the genetic composition of tumor cells, on survival, and at the recruitment of immune cells at the microenvironment. In this review, the role of EBV in the pathogenesis of DLBCL is discussed.

show abstract

“…In den letzten Jahren wurden zusätzlich zum BIA-ALCL auch implantatassoziierte, diffus großzellige B-Zell-Lymphome (DLBCL) beschrieben, wie das brustimplantatassoziierte, EBV-positive, diffus großzellige B-Zell-Lymphom [44,45,46,47]. Diese sind meist negativ für ALK, CD2, CD3, und B-Zell-Marker [48], jedoch u. a. CD20- [44,47,48,49], CD5-, BCL-2-, CD21-, CD23-, IgD-, IgM-positiv [49], im Falle von EBV-positiven, diffus großzelligen B-Zell-Lymphomen CD20-, CD30-, CD79a-, MUM1-und PAX-5-positiv [44,47,48] und ähnlich zum BIA-ALCL in den meisten Fällen mit texturierten Implantaten assoziiert [45,47]. In einem Fall wurde ein DLBCL jedoch auch nach Implantation eines glattwandigen Implantats beschrieben [50].…”

Section: Weitere Brustimplantatassoziierte Tumorenunclassified

Brustimplantatassoziierte Tumoren

von Fritschen,

Kremer,

Prantl

et al. 2024

Senologie - Zeitschrift für Mammadiagnostik und -therapie

View full text Add to dashboard Cite

ZusammenfassungZusätzlich zu dem anaplastischen großzelligen T-Zell-Lymphom (BIA-ALCL) werden seit einigen Jahren weitere Tumoren im Zusammenhang mit Implantaten beschrieben. Sehr selten traten Plattenepithelkarzinome (SSC) und B-Zell-Lymphome auf. Die ungeklärte Pathogenese sowie das unklare individuelle Risikoprofil bringen eine anhaltende Verunsicherung von Patienten und Ärzten mit sich. Während das BIA-ALCL gehäuft im Zusammenhang mit texturierten Brustimplantaten auftritt, wurden die anderen Tumoren auch bei glattwandiger Textur und anderen Implantatlokalisationen beobachtet. Multiple potenzielle Mechanismen werden diskutiert. Eine vermutlich multifaktorielle Genese, die zu einer chronischen Entzündungsreaktion mit konsekutiver Immunstimulation führt, scheint eine Schlüsselrolle bei der malignen Transformation zu spielen. Für eine spezifische Risikobewertung liegen bisher keine ausreichend validen Daten vor, weshalb diese zurückhaltend erfolgen muss. Dargestellt werden Inzidenz, Pathogenese und Evidenzlevel des aktuellen Wissensstands sowie eine Bewertung und Diskussion der aktuellen Literatur.

show abstract

EBV positive fibrin/chronic inflammation associated diffuse large B-cell lymphoma: an incidental finding associated with a breast implant

Cited by 16 publications

References 10 publications

EBV-negative Fibrin-Associated Large B-Cell Lymphoma Arising in Thyroid Hyperplastic Nodule: Report of a Case and Literature Review

EBV-negative Fibrin-Associated Large B-Cell Lymphoma Arising in Thyroid Hyperplastic Nodule: Report of a Case and Literature Review

Advances in the Pathogenesis of EBV-Associated Diffuse Large B Cell Lymphoma

Brustimplantatassoziierte Tumoren

Contact Info

Product

Resources

About