EBV-positive mucocutaneous ulcer presenting as a nasopharyngeal tumor in an immune suppressed patient

Law, Richard H.; Rizzi, Mark D.

doi:10.1016/j.amjoto.2022.103685

Cited by 2 publications

(2 citation statements)

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“…Some authors consider that various viruses have been associated with oral cancerogenesis [ 26 , 27 , 28 , 29 , 30 , 31 ]. Among them, HPV is historically and universally responsible for head and neck cancers of the oropharynx (OPC) and, as a matter of fact, from a clinical standpoint the evaluation of HPV-related markers is a valid parameter in the potential adjuvant or neoadjuvant treatment of oropharyngeal cancer regarding radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

“…In detail, HPV-16 is responsible for almost 90% of HPV-positive oropharyngeal cancers [ 32 , 33 , 34 ], mainly in men. Regarding the HPV-related cancers of the oral cavity proper, and thus excluding the OPCs, more than 97% of OSCCs are HPV-negative [ 27 ], and those that are positive could represent a subgroup of OSCCs of the base tongue [ 31 ]. Hence, HPV’s pathogenic role in OSCC is still debated.…”

Section: Introductionmentioning

confidence: 99%

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Personalized Medicine in Oral Oncology: Imaging Methods and Biological Markers to Support Diagnosis of Oral Squamous Cell Carcinoma (OSCC): A Narrative Literature Review

Menditti,

Santagata,

Imola

et al. 2023

JPM

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For decades, oral squamous cell carcinoma (OSCC) has been one of the most prevalent and mortal cancers worldwide. The gold standard for OSCC diagnosis is still histopathology but this narrative multidisciplinary review has the aim to explore the literature about conventional OSCC prognostic indicators related to the pTNM stage at the diagnosis such as the depth of invasion and the lymphovascular invasion associated with distant metastasis as indicators of poor life expectancy. Despite its multifactorial nature and recognizable precursors, its diagnosis at the early stages is still challenging. We wanted to highlight the importance of the screening as a primary weapon that a stomatologist should consider, intercepting all at-risk conditions and lesions associated with OSCC and its early stages. This narrative review also overviews the most promising imaging techniques, such as CT, MRI, and US-echography, and their application related to clinical and surgical practice, but also the most-investigated prognostic and diagnostic tissue and salivary biomarkers helpful in OSCC diagnosis and prognostic assessment. Our work highlighted remarkable potential biomarkers that could have a leading role in the future. However, we are still far from defining an appropriate and concrete protocol to apply in clinical practice. The hope is that the present and future research will overcome these limitations to benefit patients, clinicians, and welfare.

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