EBV status has prognostic implication among young patients with angioimmunoblastic T‐cell lymphoma

Abstract

Epstein-Barr virus (EBV)-positive B cells have been detected in 66%-86% of patients with angioimmunoblastic T-cell lymphoma (AITL). However, it remains controversial whether EBV status has an impact on the survival of patients with AITL. In this study, we aimed to reevaluate the impact of EBV on the clinicopathological characteristics of AITL. In particular, we focused on the impact of EBV in younger patients with AITL. In total, 270 cases of AITL were studied. Epstein-Barr virus-positive B cells were detected in 191 (71%) cases (EBER + group). Among the patients who received anthracycline-based therapy, the EBER status did not affect the overall survival (OS) or progression-free survival (PFS). In the younger group of AITL (≤60 years), PFS was significantly worse in the EBER − group compared to the EBER + group (P = .0013). Furthermore, the multivariate analysis identified EBER-negative status, thrombocytopenia, and elevated serum IgA level as significant adverse prognostic factors for PFS (P < .001, P < .001, and P = .002). Based on these findings, we constructed new prognostic model for the younger group, based on three adverse factors. We classified the patients into two risk groups: low risk (no or 1 adverse factor) and high risk (2 or 3 adverse factors). This new model for younger patients with AITL showed that both OS and PFS were significantly related | 679 ELADL Et AL.

A comprehensive analysis of RHOA mutation positive and negative angioimmunoblastic T-cell�lymphomas by targeted deep sequencing, expression profiling and single cell digital image analysis

“…Kaplan-Meier Survival analysis was performed with regards to EBV infection, and the results demonstrated no improved overall survival for EBV positive cases. Our results do not confirm these previous findings of Eladl et al ( 50 ) but our sample size is small. Another study by Hoffman et al ( 51 ) assessed the association between EBV infection and diffuse large B-cell lymphoma (DLBCL) occurring in PTCL, and reported that patients with PTCL and DLBCL frequently have EBV infected B-cells, suggesting an important role of EBV in B-cell transformation.…”

CD4-Targeted T Cells Rapidly Induce Remissions in Mice with T Cell Lymphoma

“…T cell lymphoma is a rare form of cancerous lymphoma affecting T cells, which represents less than 15% of all non-Hodgkin's diseases. Various risk factors and virus infections such as Epstein Barr virus and human T cell leukemia virus-1 account for the progression of T cell lymphoma [ 25 , 26 ]. Unfortunately, there is no effective therapeutics for the debilitating disease so far.…”

The Early Diagnostic Dilemma in Angioimmunoblastic T Cell Lymphoma with Excessive Plasma Cells Proliferation

“…e ultimate differentiation of EBV-infected B cells into PC was related to EBV replication, which is suppressed by a strong T cell immune response in EBV-seropositive healthy people [32]. EBVpositive B cells can be detected in 66-86% patients of AITL, on account of immunosuppression due to AITL [33]. Tumor T cells, cytokines, and EBV infection may potentially cause polyclonal plasma cell expansion.…”