Ecballium elaterium (L.) A. Rich. seed oil: Chemical composition and antiproliferative effect on human colonic adenocarcinoma and fibrosarcoma cancer cell lines

Touihri, Imen; Kallech-Ziri, Olfa; Boulila, Abdennacer; Fatnassi, Saloua; Marrakchi, Naziha; Luis, José; Hanchi, Belgacem

doi:10.1016/j.arabjc.2015.02.023

Cited by 15 publications

(11 citation statements)

References 32 publications

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“…Several studies reported that either E. elaterium or its isolated constituents from this particular species and/or other members of cucurbitaceae family act as natural antiproliferative agents against several cell lines such as gastric, esophageal [5], prostate, melanoma, ovary [28,29], leukemia [30], glioblastoma [31], breast [28,32], hepatocytes [33], colon [34], peripheral lymphocytes [35,36] and pancreatic cancer cells [37]. In line with our results, the E. elaterium seed oil inhibited growth of human colonic adenocarcinoma (HT29) and fibrosarcoma (HT1080) cell lines with the IC50 values 4.86 μg/mL and 4.16 μg/mL [38]. Our findings in renal adenocarcinoma ACHN and pancreas adenocarcinoma ASPC1 cell lines were also similar to those of E. elaterium fruit freezedried extract for growth of human gastric carcinoma cell lines (2.5 μg/mL).…”

Section: Discussionsupporting

confidence: 85%

A Toxicological and Phytochemical Study on the Iran’s Ecballium elaterium (L.) A. Rich.

et al. 2019

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Background: Ecballium elaterium is endemic to the northwestern Iran and its fruit is traditionally used for therapeutic purposes in Iran. The toxicological and phytochemical characteristics of the Iran's Ecballium elaterium have not been investigated so far.Objective: Study on some toxicological and phytochemical features of the Iran's Ecballium elaterium fruit 90% ethanol extract. Method:The antioxidant capacity in the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay and total phenol and flavonoid contents were determined by spectrophotometry. The rutin (phytomyelin) content was measured by HPLC. Moreover, oral and intra-peritoneal LD50 (median lethal dose) after 72 hours of the extract administration in rat were determined by the graphical method of Miller and Tainter. The cytotoxicity against several cancer and non-cancer cell lines was determined by the MTT (mitochondrial tetrazolium) method.Results: The IC50 (inhibitory concentration 50%) in the DPPH assay was 3.57±0.006 mg/mL. The total phenol in terms of mg Gallic acid/0.05 g extract was 17.84±0.92. The total flavonoid in terms of mg rutin/0.1 g extract was 33.35 ± 1.06. The extract contained 1 mg/g rutin. The oral and intraperitoneal LD50 of the extract were 472 mg/kg and 425 mg/kg respectively. The extract showed strong cytotoxicity in ACHN and ASPC1 cell lines, which was followed by Caco2 and PC12 cells. Non-neoplastic cells were much less affected by the extract in comparison with the cancerous cells. Conclusion:The extract has low antioxidant activity. The oral and intra-peritoneal toxicities of the extract in the LD50 test are moderate. The extract has considerable selective toxicity against cancer cells.

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Section: Discussionsupporting

confidence: 85%

A Toxicological and Phytochemical Study on the Iran’s Ecballium elaterium (L.) A. Rich.

et al. 2019

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“…Dune species can be evaluated as alternative oleic acid resources and adaptation of oleic acid rich crop plants to the salt effected soils by means of breeding and biotechnological crop improving programs. Besides, punicic acid as an unusual omega-5 fatty acidhas been detected at the considerable level up to 20.32% in the seeds of Ecballium elaterium having broad tolerance to various edaphic conditions, corresponding with the previous result at about 22% percent in the seeds [39,40]. Punicic acid, a special conjugate form of linoleic acid is found in the stone of pomegranate at high ratio (64-83%).…”

Section: Evaluation Of the Results On Fatty Acidsmentioning

confidence: 50%

Fatty Acid and Amino Acid Profiles in Some Dune Vegetation Species from Istanbul

Taç

Özcan

2019

Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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Dunes are one of the most dynamic ecosystems in the nature and they are considered as a special habitat type hosting valuable genetic resources. Dunes located in Turkey are very rich in terms of plant diversity. Istanbul has special place for the richness of endemic and rare species in its dune vegetations. Biochemical characteristics of some plant species growing in Istanbul dunes, which are under immense threat during the recent years have been examined in the present study. Seed samples and aerial parts of the plants have been analysed for fatty acid and amino acid compositions. The higher concentrations of α-linolenic acid were quantified in Euphorbia paralias (48.24%) and Diplotaxis tenuifolia (24.47%). Linoleic acid concentrations were detected at the higher levels in Xanthium strumarium (68.51%) and Otanthus maritimus (66.62%). Eryngium campestre (44.97%), Cyperus capitatus (44.27%) and Eryngium maritimum (41.88%) were found to have high oleic acid concentrations. 20,32% punicic acid was detected in Ecballium elaterium. The higher concentrations of some essential amino acids were observed in the seeds. Proline is the dominant amino acid in the aerial parts of all taxa examined. Significant correlations between amino acid concentrations were calculated. The data obtained in the present study reveal that regarding plants as novel crops can be efficient for utilization in biochemical and biotechnological applications in many fields such as human nutrition, health and other industrial purposes.

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“…Infusions from Mentha spp., Rosmarinus officinalis and Origanum majorana inhibited the growth of several cancer cell lines, including HeLa, Jurkat and MCF-7 (Elansary and Mahmoud, 2015 ). Seed oil isolated from Ecbalium elaterium inhibited the growth of HT-29 colonic adenocarcinoma (IC 50 = 4.86 μg/mL) and HT-1080 colonic fibrosarcoma cells (IC 50 = 4.16 μg/mL; Touihri et al, 2015 ). Treating MCF-7 and OVCAR cells with 50 mg/L of hydromethanolic extract from the flower buds of Cistus salviifolius inhibited the growth by 35.16 and 36.85%, respectively (El Euch et al, 2015 ).…”

Section: Scientific Evidence On Medicinal Plants Not Traditionally Usmentioning

confidence: 99%

North African Medicinal Plants Traditionally Used in Cancer Therapy

et al. 2017

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Background: Cancer is a major cause of mortality worldwide with increasing numbers by the years. In North Africa, the number of cancer patients is alarming. Also shocking is that a huge number of cancer patients only have access to traditional medicines due to several factors, e.g., economic difficulties. In fact, medicinal plants are widely used for the treatment of several pathologies, including cancer. Truthfully, herbalists and botanists in North African countries prescribe several plants for cancer treatment. Despite the popularity and the potential of medicinal plants for the treatment of cancer, scientific evidence on their anticancer effects are still scarce for most of the described plants.Objective: Bearing in mind the lack of comprehensive and systematic studies, the aim of this review is to give an overview of studies, namely ethnobotanical surveys and experimental evidence of anticancer effects regarding medicinal plants used in North Africa for cancer therapy.Method: The research was conducted on several popular search engines including PubMed, Science Direct, Scopus and Web of Science. The research focused primarily on English written papers published between the years 2000 and 2016.Results: This review on plants traditionally used by herbalists in North Africa highlights that Morocco and Algeria are the countries with most surveys on the use of medicinal plants in folk medicine. Among the plethora of plants used, Nigella sativa and Trigonella foenum-graecum are the most referred ones by herbalists for the treatment of cancer. Moreover, a plethora of scientific evidence qualifies them as candidates for further drug development. Furthermore, we report on the underlying cellular and molecular mechanisms.Conclusion: Overall, this review highlights the therapeutic potential of some medicinal plants as anticancer agents. The North African flora offers a rich source of medicinal plants for a wide array of diseases, including cancer. The elucidation of their modes of action represents an indispensable condition for the rational development of new drugs for cancer treatment. Furthermore, testing the anticancer activity in vivo and in clinical trials are warranted to explore the full therapeutic potential of North African plants for cancer therapy.

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Ecballium elaterium (L.) A. Rich. seed oil: Chemical composition and antiproliferative effect on human colonic adenocarcinoma and fibrosarcoma cancer cell lines

Cited by 15 publications

References 32 publications

A Toxicological and Phytochemical Study on the Iran’s Ecballium elaterium (L.) A. Rich.

A Toxicological and Phytochemical Study on the Iran’s Ecballium elaterium (L.) A. Rich.

Fatty Acid and Amino Acid Profiles in Some Dune Vegetation Species from Istanbul

North African Medicinal Plants Traditionally Used in Cancer Therapy

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