Eccrine Angiomatous Hamartoma in an Adolescent

Abstract

Eccrine angiomatous hamartoma is a rare hamartoma that usually affects childhood and adolescence. In this report we describe a typical onset and clinical presentation of eccrine angiomatous hamartoma. Histopathological analysis and immunohistochemical staining of the sections were done to confirm the diagnosis.

Hairless Hyperhidrotic Plaque in a Young Male

“…[ 1 ] The disease shows no gender or racial predilection and primarily affects young children, though cases have been described in adolescents and adults as well. [ 2 ] The exact pathogenesis is unclear; however, faulty biochemical interactions between the differentiating epithelium and mesenchyme leading to abnormal eccrine and vascular proliferation have been proposed. [ 3 ] While distal extremities are a common site, occurrence on head and neck has also been reported.…”

Adult-onset Eccrine Angiomatous Hamartoma

“…EAH usually originates from an abnormal interaction between the differentiated epithelium and the mesenchyme which results in atypical development of eccrine and vascular elements. [ 1 ]…”

“…There is no sex predilection. [ 1 2 ] It clinically presents as a solitary nodule commonly affecting the extremities. Approximately 80% of the cases are reported on the extremities, with a predilection for palm and sole involvement.…”

“…Diagnosis of EAH is based upon the histologic criteria described as[ 1 ] proliferation of mature, normal or dilated eccrine glands,[ 2 ] the intimate relationship of the eccrine structures with benign vascular proliferation,[ 3 ] and varying occurrence of pilar, lipomatous, mucinous, and/or lymphatic structures. [ 6 ]…”

“…The lesion may expend in proportion with the patient's growth. [ 1 ] Surgical excision is curative and reserved for cases accompanying local pain or cosmetically disfiguring lesions, but recurrence is likely to occur. [ 1 4 7 ]…”