Eccrine gland clear reticulated cytoplasm

Burket, John M.; Brooks, Robert E.; Burket, Denise A.

doi:10.1016/s0190-9622(85)70193-4

Cited by 14 publications

(16 citation statements)

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“…In his case report, he describes the content of secretory cells to be PAS positive and resistant to diastase degradation. 6 Saga and Jimbow 8 reported negative staining with PAS in a series of 5 cases. The vacuoles, or clear cell changes, are confined to the secretory portion of the gland and are membrane bound.…”

Section: Discussionmentioning

confidence: 94%

“…8 It has been noted to be present in all eccrine glands in the same patients and remains present over time. 1,6 This enigmatic entity is of uncertain clinical significance. It has been noticed as an incidental finding present in skin biopsies from a range of anatomical sites in patients with a host of different dermatological conditions.…”

Section: Discussionmentioning

confidence: 99%

“…It has been noticed as an incidental finding present in skin biopsies from a range of anatomical sites in patients with a host of different dermatological conditions. [6][7][8] It is thought to be a true feature rather than an artifact of tissue handling and processing. 1,6 So far, there have been no unifying patient characteristics or any consistent disease associations to account for this finding.…”

Section: Discussionmentioning

confidence: 99%

“…8 A number of theories have been proposed: First, that it represents a normal physiological variant; 6,7 second, that the vacuoles represent lysosomes; or finally, that they are autolytic remnants. 6 The exact composition of the contents of these vacuoles is uncertain. Recent work demonstrates the presence of positive immunohistochemical staining for mammary gland antigens (a 1 -antitrypsin, a 1 -antichymotrypsin, and lactoferrin).…”

Section: Discussionmentioning

confidence: 99%

“…8 Electron microscopy has not been able to shed any further light on the contents of these vacuoles. 6 The multivacuolated nature of the eccrine apparatus has been mistaken for pathological processes (mucinous syringometaplasia or clear cell syringoma). 6 Vacuolation of eccrine sweat glands has been noted in numerous other conditions.…”

Section: Discussionmentioning

confidence: 99%

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Clear Cell Change in Eccrine Glands Is Not Associated With Diabetes

Cherian

Beer²

2010

The American Journal of Dermatopathology

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The significance of clear cell change (clear reticulated cytoplasmic change) in the secretory portion of eccrine glands remains an enigma. It has been postulated to be a product of defective cellular glucose metabolism and potentially a predictor of diabetes. A series of 61 specimens from 38 patients were assessed to establish any demographic, seasonal, or metabolic associations. Sixty-one specimens from 38 patients with eccrine clear cell changes were identified prospectively by one of the authors (T.W.B.). Each specimen was stratified by site, age, sex, and season. For each patient, the general practitioner was contacted and diabetes status was ascertained. This was possible in 34 of 38 patients. Fifty routine consecutive cases from the archive in both summer and winter were studied for possible clear cell changes, looking for any seasonal variance. No clear association between the presence of eccrine clear cell change and any demographic or seasonal pattern was found. Specifically, there did not seem to be any significant association between diabetes and this histological finding. The prevalence of diabetes in cases with eccrine clear cell change was similar to the background population prevalence of diabetes in Australia (7.9% vs. 7.4%). The incidence of this finding is approximately 1 case in 189 specimens (0.5%) examined in this practice. Clear cell change within the secretory portion of eccrine glands seems to be an incidental finding, with no clear clinicopathological implication. In particular, there does not seem to be any association with diabetes.

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Section: Discussionmentioning

confidence: 94%