Eccrine porocarcinoma: an extremely rare cutaneous tumor from a radiological point of view – case report and review of the literature

Mahdar, Imane; Lembarki, Ghizlane; Jamil, Jihad; Safi-eddine, Hiba; Sabiri, Mouna; Labied, Mohamed; Manjra, Samia El; Lezar, S.; Essodegui, Fatiha; Najib, Belmoudden

doi:10.1259/bjrcr.20220044

Cited by 2 publications

(3 citation statements)

References 7 publications

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“…Finally, a few studies have addressed the radiological features of EPC. In ultrasound, it has been found to exhibit a multilobulated, well-defined lesion within the dermis and subcutaneous tissue, showing hypoechoic and heterogenous solid components with increased peripheral vascularity, as well as cystic components containing echoic spots [ 41 ]. Finally, in magnet resonance imaging (MRI), EPC has been described to include a pedunculated configuration, a homogenous T2 signal, hyperintensity in T1 weighted images and cystic components [ 41 ].…”

Section: Diagnosismentioning

confidence: 99%

Eccrine Porocarcinoma: A Review of the Literature

et al. 2023

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Eccrine porocarcinoma (EPC) constitutes a rare malignant adnexal tumor, which accounts for about 0.005–0.01% of all cutaneous malignancies. It may develop de novo or arise from an eccrine poroma, after a latency period of years or even decades. Accumulating data suggest that specific oncogenic drivers and signaling pathways may be implicated in its tumorigenesis, while recent data have demonstrated a high overall mutation rate attributed to UV exposure. Diagnosis may be challenging and should rely on the combination of clinical, dermoscopical, histopathological and immunohistochemical findings. The literature is controversial regarding tumor behavior and prognosis and, therefore, there is no consensus on its surgical management, utility of lymph-node biopsy and further adjuvant or systemic treatment. However, recent advances in tumorigenesis of EPC may aid in the development of novel treatment strategies, which could improve survival of advanced or metastatic disease, such as immunotherapy. This review presents an update of the epidemiology, pathogenesis and clinical presentation of EPC and summarizes current data on diagnostic evaluation and management of this rare cutaneous malignancy.

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Section: Diagnosismentioning

confidence: 99%

Eccrine Porocarcinoma: A Review of the Literature

et al. 2023

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“…The lesion displayed hypoechoic and heterogeneous solid components with increased peripheral vascularity, as well as cystic components containing echoic spots. These ultrasound findings are important in diagnosing EC and can help in distinguishing it from other malignant tumors such as malignant melanomas or basal cell carcinomas that are identifiable with low area under curve on ultrasound [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…T2WI provides information on signal intensity and tumor cellularity while fat-suppressed T2WI detects peritumoral fat stranding and adjacent tissue invasion. MR imaging can be useful in diagnosing EC, with MR findings of eccrine porocarcinoma (EPC) including a pedunculated configuration, homogenous T2 signal, hyperintensity in T1 weighted images, and the presence of cystic components [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Eccrine Carcinoma Demonstrating Intracranial Invasion in a Patient With Advanced Hepatocellular Carcinoma

Dossani,

Irshad,

Ibrahim

et al. 2024

Cureus

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Eccrine carcinoma (EC) is a rare intraepidermal carcinoma of the eccrine sweat glands. Even more rare are instances of EC exhibiting intracranial invasion. Here, we describe the case of a metachronous EC mass demonstrating intracranial invasion in a patient with advanced-stage hepatocellular carcinoma (HCC), reporting CT head findings of a left frontal skull expansile destructive mass with soft tissue density and immunostain findings of the following: CEA: positive, granular, EMA: positive, AE1/AE3: positive, CK7: strongly positive, CK20: negative, GCDFP: negative, and HEPAR: negative. The only recommended treatment for EC is surgical excision with tumor-free margins, and no chemotherapy protocols currently exist. Due to socioeconomic factors, our patient was unable to receive adequate treatment for her HCC, nor surgical excision for her EC. However, the unique presentation of a rare intracranial EC tumor causing no neurological deficits in a patient with untreated HCC merits the need for a more thorough identification of secondary tumors via biopsy in patients with HCC to identify possible associations between these two tumors in future patients.

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Eccrine porocarcinoma: an extremely rare cutaneous tumor from a radiological point of view – case report and review of the literature

Cited by 2 publications

References 7 publications

Eccrine Porocarcinoma: A Review of the Literature

Eccrine Porocarcinoma: A Review of the Literature

A Rare Case of Eccrine Carcinoma Demonstrating Intracranial Invasion in a Patient With Advanced Hepatocellular Carcinoma

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