Eccrine Poroma Arising within Nevus Sebaceous

N, Girdwichai; Chanprapaph, Kumutnart; Vachiramon, Vasanop

doi:10.1159/000445537

Cited by 3 publications

(6 citation statements)

References 20 publications

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“…Poroma has been found to occur in patients with other skin diseases, and it can also develop within NS 6 . To the best of our knowledge, there are only six reported cases of poroma arising within NS ( Table 1 ) 1 7 8 9 10 11 .…”

Section: Discussionmentioning

confidence: 99%

“…2 . Trichoblastoma and syringocystadenoma papilliferum are the most common benign secondary neoplasms, while basal cell carcinoma is the most common malignant secondary neoplasm 1 . However, poroma arising within NS has rarely been reported.…”

Section: Introductionmentioning

confidence: 99%

“…Nevus sebaceous (NS) is a congenital, benign, cutaneous hamartoma, which commonly occurs at birth and is located in the head and neck. It presents at first as well-demarcated skin-colored hairless plaques, and becomes more yellowish, thickening and verrucous at puberty 1 . Secondary neoplasms arising within NS can develop during adolescence and adulthood.…”

Section: Introductionmentioning

confidence: 99%

“…One study found that 21.4% of lesions with NS developed secondary neoplasms; benign tumors accounted for 18.9%, whereas malignant tumors comprised the remaining 2.5% 2 . Trichoblastoma and syringocystadenoma papilliferum are the most common benign secondary neoplasms, while basal cell carcinoma is the most common malignant secondary neoplasm 1 . However, poroma arising within NS has rarely been reported.…”

Section: Introductionmentioning

confidence: 99%

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Eccrine Poroma Arising within Nevus Sebaceous

et al. 2020

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Secondary neoplasms in nevus sebaceous can develop during adolescence and adulthood. Trichoblastoma and syringocystadenoma papilliferum are the most common benign neoplasms, but poroma is rarely reported. A 28-year-old female presented with an asymptomatic mass on the scalp. She has had a hairless lesion on the scalp since birth. A soft mass developed on that lesion four years prior. Physical examination revealed a localized 1 cm×2.5 cm-sized brownish, verrucous-surfaced plaque with a 1 cm×1 cm-sized pedunculated erythematous tumor on the scalp. We performed skin biopsy on both the plaque and tumor lesions. The histopathological findings demonstrated the plaque lesion consistent with nevus sebaceous and the tumor lesion consistent with eccrine poroma. Surgical mass excision was performed. The patient was eventually diagnosed with eccrine poroma arising within nevus sebaceous. To the best of our knowledge, there are only six reported cases on poroma arising within nevus sebaceous. Although rarely documented in the literature, it should be considered as a secondary neoplasm within nevus sebaceous.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Eccrine Poroma Arising within Nevus Sebaceous

et al. 2020

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“…Most common benign lesions are trichoblastoma, syringocystadenoma papilliferum, while the most common malignant lesion is basal cell carcinoma (4,5). Very rarely, eccrine poroma (EP) can occur in NS and mimic other benign and malignant tumors (6). EP is a benign neoplasm arising from the sweat gland ducts.…”

Section: Introductionmentioning

confidence: 99%

Secondary Tumor Arising in a Nevus Sebaceous

Gajinov

Prćić

et al. 2020

Serbian Journal of Dermatology and Venereology

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Introduction. Nevus sebaceous is a rare congenital hamartoma, composed of epidermis, sebaceous glands, sweat glands and hair follicles. It is possible to develop secondary tumors in the area of nevus sebaceous during the lifetime, most often after puberty. Secondary lesions are most often benign, while malignant lesions may occur but significantly less frequently. Case report. We present the case of a 21-year-old patient who came for an examination due to the appearance of a nodule in the area of a yellowish lesion on the head. The yellowish lesion was present since birth, and the nodule appeared about a year before. The dermoscopic examination of the lesion was nonspecific. The final diagnosis of eccrine poroma as a secondary lesion in nevus sebaceous was made by pathohisto-logical analysis. Conclusion. Every secondary tumor in nevus sebaceous deserves full attention, with either close follow up, or excision with pathohistological analysis.

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Eccrine Porocarcinoma: A Review of the Literature

et al. 2023

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Eccrine porocarcinoma (EPC) constitutes a rare malignant adnexal tumor, which accounts for about 0.005–0.01% of all cutaneous malignancies. It may develop de novo or arise from an eccrine poroma, after a latency period of years or even decades. Accumulating data suggest that specific oncogenic drivers and signaling pathways may be implicated in its tumorigenesis, while recent data have demonstrated a high overall mutation rate attributed to UV exposure. Diagnosis may be challenging and should rely on the combination of clinical, dermoscopical, histopathological and immunohistochemical findings. The literature is controversial regarding tumor behavior and prognosis and, therefore, there is no consensus on its surgical management, utility of lymph-node biopsy and further adjuvant or systemic treatment. However, recent advances in tumorigenesis of EPC may aid in the development of novel treatment strategies, which could improve survival of advanced or metastatic disease, such as immunotherapy. This review presents an update of the epidemiology, pathogenesis and clinical presentation of EPC and summarizes current data on diagnostic evaluation and management of this rare cutaneous malignancy.

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Eccrine Poroma Arising within Nevus Sebaceous

Cited by 3 publications

References 20 publications

Eccrine Poroma Arising within Nevus Sebaceous

Eccrine Poroma Arising within Nevus Sebaceous

Secondary Tumor Arising in a Nevus Sebaceous

Eccrine Porocarcinoma: A Review of the Literature

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