Eccrine poromatosis following chemotherapy and radiation therapy

Nguyen, Khoa D.; Kim, Gene; Chiu, Melvin

doi:10.5070/d32511046146

Cited by 11 publications

(11 citation statements)

References 13 publications

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“…Poromatosis has mainly been reported in patients with malignancies. In previous cases, leukemia and/or lymphoma was the malignancy most commonly associated with poromatois 3–7 . Patients often received treatments, such as transplantation and chemotherapy, sometimes with radiotherapy 3–7 .…”

Section: Discussionmentioning

confidence: 99%

“…Poromas typically occur as solitary papules or nodules on the sole or palm but can be found anywhere on the skin 2 . Multiple poromas (i.e., poromatosis) occur rarely, mainly in patients with hematopoietic or visceral malignancies 3–9 . Patients often have a history of treatments such as transplantation, chemotherapy, and radiotherapy, suggesting an association between poromatosis and immunosuppressive treatment 3–9 .…”

Section: Introductionmentioning

confidence: 99%

“…Multiple poromas (i.e., poromatosis) occur rarely, mainly in patients with hematopoietic or visceral malignancies 3–9 . Patients often have a history of treatments such as transplantation, chemotherapy, and radiotherapy, suggesting an association between poromatosis and immunosuppressive treatment 3–9 . The onset of poromatosis in a pregnant woman 10 and in a breast cancer patient treated with endocrine therapy 8 have indicated an association between hormonal changes and poromatosis.…”

Section: Introductionmentioning

confidence: 99%

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YAP1::MAML2 fusions in poromatosis: A report of two patients

et al. 2023

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Poromatosis is a rare condition characterized by the development of multiple poromas, mainly reported in patients with a history of malignancy. Recently, frequent YAP1::MAML2 and YAP1::NUTM1 fusions have been described in poromas and porocarcinomas. To date, the molecular features of poromatosis have been investigated in one patient only, wherein the poromas harbored YAP1::MAML2 fusions. Herein, we present two additional cases of poromatosis with YAP1::MAML2 fusions. Case 1: An 81‐year‐old woman presented with nine papules on the scalp, trunk, and extremities persisting for a year. She had a history of breast cancer, with no information on the treatment. Seven papules were excised. Case 2: A 65‐year‐old woman presented with 21 lesions on her trunk and lower extremities persisting for 2 years. She had been diagnosed with breast cancer 11 years prior and had undergone partial mastectomy, radiotherapy, chemotherapy, and endocrine therapy. Four lesions were excised. All 11 lesions in both patients were histopathologically similar: anastomosing cords and strands extending from the epidermis, and poroid and cuticular cell proliferation with interspersed small ducts. The tumors showed diffuse nuclear expression of YAP1 N‐terminus and loss of YAP1 C‐terminus expression. No lesions showed NUT immunopositivity. Sanger sequencing identified YAP1::MAML2 fusions in the poromas of both patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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YAP1::MAML2 fusions in poromatosis: A report of two patients

et al. 2023

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“…It occasionally occurs as multiple lesions, known as poromatosis. Although its pathogenesis remains to be elucidated, most cases of multiple poromas occur in patients who have received radiotherapy or cancer chemotherapy ( 1 – 15 ). An immunosuppressive condition might be involved in the development of multiple poromas.…”

Section: Discussionmentioning

confidence: 99%

Polypoidal Manifestation of Multiple Poromas: Possible Drug Involvement

Yoshida

Yamada²,

Yamamoto³

2020

Acta Derm Venereol

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“…Eccrine poromatosis, which involves multiple tumors, is very rare. The condition was first reported by Goldner 1) in 1970 and only a handful of cases have been reported [1][2][3][4][5][6][7][8][9][10][11] . Across these reported cases, there have been two common findings: 1) a history of immunosuppression (chemotherapy, radiation therapy, or bone marrow transplantation) and 2) an anatomic distribution primarily involving the extremities.…”

Section: Introductionmentioning

confidence: 99%

A Case of Multiple Eccrine Poromas with a History of Chemotherapy and Allogeneic Peripheral Blood Stem Cell Transplantation

Yoshiike

Kawai

Nishimoto

et al. 2023

JPRS

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A "poroid cell neoplasm" is a general term used to describe nodular tumors that consist of poroid cells and cuticular cells. Eccrine poroma, the most common type of poroid cell neolplasm, is a tumor continuous with the epidermis and extends into the dermis in a cord-like fashion. This tumor is almost always seen as a single lesion, with cases of multiple eccrine poromas (eccrine poromatosis) being exceedingly rare. In fact, there have only been about 20 reported cases of multiple eccrine poromas worldwide; all of which were associated with some immunosuppressive state. Here we report another case of eccrine poromatosis; this time in a patient who received an allogeneic peripheral blood stem cell transplant for acute lymphocytic leukemia 18 years prior. Our case of eccrine pormatosis is particularly rare that it involved a truncal tumor distribution, whereas the other reported cases were generally isolated to the extremities.

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Eccrine poromatosis following chemotherapy and radiation therapy

Cited by 11 publications

References 13 publications

YAP1::MAML2 fusions in poromatosis: A report of two patients

YAP1::MAML2 fusions in poromatosis: A report of two patients

Polypoidal Manifestation of Multiple Poromas: Possible Drug Involvement

A Case of Multiple Eccrine Poromas with a History of Chemotherapy and Allogeneic Peripheral Blood Stem Cell Transplantation

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